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32 Possible Causes for Alkaline Phosphatase Increased, Green Jaundice, Scleral Icterus

  • Cholestatic Jaundice

    Pseudo jaundice may be found in black patients with pigmented sclera, from carotinemia, uremia (a sallow yellowish pallor), and quinacrine (a yellow-green color).[ptolemy.ca] LFTs : Alkaline phosphatase: considerably increased with either extrahepatic or intrahepatic biliary disease.[patient.info] […] of urine and scleral icterus precede yellowing of skin Other causes of yellow skin carotenemia. carotenemia does not cause scleral icterus Hyperbilirubinemia per se has no[meddean.luc.edu]

  • Cholestasis

    Perera DR, Greene ML, Fenster F: Cholestasis associated with extrabiliary Hodgkin's disease. Gastroenterology 1974;67:680–685.[clevelandclinicmeded.com] In most PBC patients (95%), the level of bone-specific alkaline phosphatase was above the normal range, indicating increased bone formation.[ncbi.nlm.nih.gov] Her physical exam was remarkable for jaundice and scleral icterus without any stigmata of liver disease.[ncbi.nlm.nih.gov]

  • Portal Cirrhosis

    Kayser-Fleischer ring—brown-green ring of copper deposit around the cornea, pathognomonic for Wilson’s disease Nail changes: Muehrcke’s nails—paired horizontal white bands[aafp.org] icterus Yellow discoloration of skin, cornea, and mucous membranes Increasing serum bilirubin due to compromised hepatocyte excretory function Spider angiomata Central arteriole[pathophys.org] Scleral icterus can usually be detected if the serum bilirubin level is greater than 3.0 mg/dL.[hepatitisc.uw.edu]

  • Hemochromatosis

    […] or odd colored skin (ashen gray green or reddish) • Abdominal pain (upper right quadrant—in area of the liver) • Joint pain • Rapid weight loss • Gall bladder, pancreas or[irondisorders.org] […] girl fails to start a menstrual cycle at the proper age, has very erratic periods or stops having a period once she begins, • With MALES: hypgonadism (small testicles) • Jaundice[irondisorders.org]

  • Secondary Sclerosing Cholangitis

    Perera DR, Greene ML, Fenster F: Cholestasis associated with extrabiliary Hodgkin's disease. Gastroenterology 1974;67:680–685.[clevelandclinicmeded.com] Laboratory tests Increased serum alkaline phosphatase, transaminase, bilirubin and IgM. Mitochondrial antibodies: rarely present.[meddean.luc.edu] A 55-year-old morbidly obese male presented electively with a 2-week history of low back pain and scleral icterus for 2 days.[karger.com]

  • Liver Failure

    Kayser-Fleischer ring—brown-green ring of copper deposit around the cornea, pathognomonic for Wilson’s disease Nail changes: Muehrcke’s nails—paired horizontal white bands[aafp.org] Screening and detection tests include: Alanine aminotransferase (ALT) – an enzyme found mainly in the liver; best test to detect hepatitis Alkaline phosphatase (ALP) – an[labtestsonline.org] […] in serum IgG, and normal or only slightly elevated alkaline phosphatase.[nature.com]

  • Toxic Hepatitis

    Jaundice as a misadventure of a green tea (camellia sinensis) lover: a case report. Acta Gastroenterol Belg 2008; 71: 409-12.[livertox.nih.gov] The liver increases in size, an increase in bilirubin and alkaline phosphatase is detected in blood tests, and the level of AST and ALT enzymes changes.[en.intoxication-stop.com] A 47-year-old woman was admitted to our clinic with weakness, fatigue, pruritus, and scleral icterus that had developed 10 days prior to presentation.[ncbi.nlm.nih.gov]

  • Primary Sclerosing Cholangitis

    Perera DR, Greene ML, Fenster F: Cholestasis associated with extrabiliary Hodgkin's disease. Gastroenterology 1974;67:680–685.[clevelandclinicmeded.com] Liver function tests are usually abnormal (increased serum alkaline phosphatase (ALP) most commonly) and the bilirubin level can be raised with biliary obstruction.[royalfree.nhs.uk] Serum alkaline phosphatase levels tend to increase 3-5 times than normal.[symptoma.com]

  • Primary Biliary Cirrhosis

    Perera DR, Greene ML, Fenster F: Cholestasis associated with extrabiliary Hodgkin's disease. Gastroenterology 1974;67:680–685.[clevelandclinicmeded.com] We had also observed in the other three groups of patients that the average of the values of γ-glutamyl transpeptidase and alkaline phosphatase increases with the increase[ncbi.nlm.nih.gov] Physical exam was remarkable for scleral icterus and mild jaundice; no xanthomas were noted. Laboratory studies were performed ( Table 1 ).[clinchem.aaccjnls.org]

  • Extrahepatic Cholestasis

    Keywords: bile duct stone ; bile duct stricture ; bilirubin ; cholestasis ; jaundice ; liver function test References 1. Green RM, Flamm S.[degruyter.com] Definition Jaundice : yellowish discoloration of the skin, sclerae, and mucous membranes due to the deposition of bilirubin Scleral icterus : discoloration of the sclerae,[amboss.com] Alkaline phosphatase may be increased even if only a few small bile ducts are obstructed, and serum bilirubin is normal.[clinlabnavigator.com]

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