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2,660 Possible Causes for Alkaline Phosphatase Increased, Hyperbilirubinemia, Onset in First Weeks or Months of Life

  • Cholestasis

    Clinical description The first cholestatic episode can occur at any age but onset within the first two decades of life is most common.[orpha.net] In most PBC patients (95%), the level of bone-specific alkaline phosphatase was above the normal range, indicating increased bone formation.[ncbi.nlm.nih.gov] We believe our patient’s persistent direct hyperbilirubinemia with biopsy-confirmed cholestasis was also likely related to his AHC.[pediatrics.aappublications.org]

  • Cholelithiasis

    Patients with increased CBD dilatation more than 5 mm showed statistically significant increases in alkaline phosphatase and gamma-glutamyltransferase.[ncbi.nlm.nih.gov] All SCA patients are children (less than 16 years old) and were characterized by hyperbilirubinemia and 52 of them have cholelithiasis.[ncbi.nlm.nih.gov] […] in serum bilirubin concentration, alkaline phosphatase activity, or aspartate transaminase activity.[link.springer.com]

    Missing: Onset in First Weeks or Months of Life
  • Cholestatic Jaundice

    LFTs : Alkaline phosphatase: considerably increased with either extrahepatic or intrahepatic biliary disease.[patient.info] […] jaundice [ jawn dis ] yellowness of skin, sclerae, mucous membranes, and excretions due to hyperbilirubinemia and deposition of bile pigments.[medical-dictionary.thefreedictionary.com] Tests not found to be useful in differentiation are cholesterol esterase, alkaline phosphatase and prothrombin time.[pediatrics.aappublications.org]

    Missing: Onset in First Weeks or Months of Life
  • Infectious Mononucleosis

    Moderate hyperbilirubinemia improves renal hemodynamics in ANG II-dependent hypertension.[ncbi.nlm.nih.gov] Moderate hyperbilirubinemia improves renal hemodynamics in ANG II-dependent hypertension, Am J Physiol Regul Integr Comp Physiol, 2010, vol. 299 (pg.[academic.oup.com]

    Missing: Onset in First Weeks or Months of Life
  • Intrahepatic Cholestasis

    Clinical description The first cholestatic episode can occur at any age but onset within the first two decades of life is most common.[orpha.net] The raise at various degrees of serum bilirubin, alkaline phosphatase, and gamma-glutamyl transpeptidase, with or without increased transaminases levels, are common hematochemical[ncbi.nlm.nih.gov] Dubin-Johnson syndrome may manifest as conjugated hyperbilirubinemia, darkly pigmented liver, presence of abnormal pigment in the parenchyma of hepatocytes and abnormal distribution[ncbi.nlm.nih.gov]

  • Progressive Familial Intrahepatic Cholestasis

    She presented with jaundice, pruritus, and increased bilirubin levels, together with elevated gamma glutamyl transferase and alkaline phosphatase levels.[ncbi.nlm.nih.gov] Conjugated hyperbilirubinemia (total serum bilirubin 7.0 mg/dL, conjugated 5.0 mg/dL), high alkaline phosphatase (630 U/L; reference range for adults 35-150) normal serum[indianpediatrics.net] Ursodeoxycholic acid in the treatment of cholestasis and hyperbilirubinemia in pediatric intensive care unit patients. South Med J. 2002;95: 1276-79.[meddocsonline.org]

    Missing: Onset in First Weeks or Months of Life
  • Sarcoidosis

    Phosphate and alkaline phosphatase may be increased. LFTs may show derangement. If calcium is elevated then 24-hour urinary collection may demonstrate hypercalciuria.[patient.info] phosphatase Hypercalcemia/hypercalciuria/nephrolithiasis Increased serum calcium with no other cause Increased urine calcium Nephrolithiasis, no stone analysis Nephrolithiasis[doi.org] […] hepatic enzymes or alkaline phosphatase.[en.wikipedia.org]

    Missing: Onset in First Weeks or Months of Life
  • Sepsis

    Early-onset sepsis is seen in the first week of life. Late onset sepsis occurs after 1 week through 3 months of age.[medlineplus.gov] Three days after initiation of ECMO, the patient developed jaundice, with increase of bilirubin, Gamma-glutamyltransferase and Alkaline phosphatase, without elevation of alanine[ncbi.nlm.nih.gov] […] without a qSOFA score  2 because different forms of organ dysfunction may be present than are assessed using the qSOFA, such as hypoxemia, renal failure, coagulopathy, or hyperbilirubinemia[doi.org]

  • Wilson Disease

    phosphatase/total bilirubin 4, and an increase in serum total copper levels.[wjgnet.com] He was deeply icteric with ascites, hepatosplenomegaly, hyperbilirubinemia, raised transaminases, and coagulopathy.[ncbi.nlm.nih.gov] "Importance of UDP-Glucuronosyltransferase 1A1 Expression in Skin and Its Induction by UVB in Neonatal Hyperbilirubinemia".[en.wikipedia.org]

    Missing: Onset in First Weeks or Months of Life
  • Neonatal Hepatitis

    Serum alanine aminotransferase and aspartate aminotransferase showed moderate elevations (110 IU/l and 61.5 IU/l, respectively), as well as the alkaline phosphatase which[ncbi.nlm.nih.gov] The levels of glutamic acid (Glu) in the BA group were significantly elevated compared to those in the NHS group, but still lower than the hyperbilirubinemia and normal controls[ncbi.nlm.nih.gov] Liver-function tests were also markedly deranged at this time, with maximum values for serum alanine transferase, bilirubin, alkaline phosphatase, and ammonia concentration[ncbi.nlm.nih.gov]

    Missing: Onset in First Weeks or Months of Life

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