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51 Possible Causes for Alkaline Phosphatase Increased, Hypergammaglobulinemia, Thrombocytosis

  • Sarcoidosis

    Serum protein electrophoresis is an easily accessible and routinely performed examination at diagnosis, in order to search for hypergammaglobulinemia, which is frequently[] Phosphate and alkaline phosphatase may be increased. LFTs may show derangement. If calcium is elevated then 24-hour urinary collection may demonstrate hypercalciuria.[] […] insipidus Serum blood tests will show hypercalcemia and ACE levels 4 x normal ESR is often elevated Laboratory findings include leukopenia, hypercalcemia, hypercalciuria, and hypergammaglobulinemia[]

  • Lymph Node Hyperplasia

    Severe peripheral neuropathy usually occurs in the setting of multicentric, plasma cell-type disease with hypergammaglobulinemia and is often responsive to immunosuppressive[] […] multicentric angiofollicular lymph node hyperplasia had a distinct clinical syndrome characterized by peripheral neuropathy, pseudotumor cerebri, IgA dysproteinemia, and thrombocytosis[] […] of serum alkaline phosphatase and gamma glutamyl transpeptidase activity.[]

  • Chronic Neutrophilic Leukemia

    AML ( Acute basophilic ) CFU-Eos AML ( Acute eosinophilic ) MP ( Chronic eosinophilic leukemia / Hypereosinophilic syndrome ) MEP CFU-Meg AML ( AMKL/M7 ) MP ( Essential thrombocytosis[] Increased serum vitamin B12, increased serum urine acid levels and increased leukocyte alkaline phosphatase activity are the associated features in the absence of fever or[] The diagnosis of MM was based on IgG kappa monoclonal hypergammaglobulinemia and increased plasmablasts and plasma cells in BM aspirates.[]

  • Polycythemia

    .- ) hypergammaglobulinemia NOS ( D89.2 ) lymphadenitis NOS ( I88.9 ) mesenteric lymphadenitis (acute) (chronic) ( I88.0 ) Other and unspecified diseases of blood and blood-forming[] […] and leukocytosis or thrombocytosis, or all three together.[] Increased leucocytosis is seen in more than half of the patients and even may see increased basophils. Increased neutrophil alkaline phosphatase score (NAP).[]

  • Polymyalgia Rheumatica

    Anemia of chronic disease, leukocytosis, reactive thrombocytosis, and decreased albumin are also common. Alkaline phosphatase and hepatic enzymes may be elevated.[] Platelet counts are often increased. • Liver function tests reveal normal transaminase enzyme levels. Alkaline phosphatase may be mildly increased.[] Other laboratory signs of inflammation may include: thrombocytosis, leukocytosis, anemia, hypoalbuminemia, polyclonal hypergammaglobulinemia, and an elevated ferritin.[]

  • Congenital Neutropenia

    […] failure of neutrophil precursors to mature beyond the promyelocyte stage, absolute increases in numbers of monocytes, eosinophils, and platelets (monocytosis, eosinophilia and thrombocytosis[] […] blood alkaline phosphatase, and headache with severe chronic neutropenia are arthralgia, bone pain, back pain, muscle spasms, musculoskeletal pain, pain in extremity, splenomegaly[] […] is refractory to granulocyte colony-stimulating factor, manifesting with life-threatening infections and/or deep-seated abscesses, hepato-/splenomegaly, thrombocytopenia, hypergammaglobulinemia[]

  • Primary Amyloidosis

    It may be associated with multiple myeloma or other B-cell lymphoproliferative diseases, like non-Hodgkin lymphoma, Waldenstrom hypergammaglobulinemia or monoclonal gammopathy[] Her past medical history was remarkable for membranoproliferative glomerulonephritis, hypertension, pulmonary hypertension, and anemia of thrombocytosis.[] Functional liver tests evidenced a high level of alkaline phosphatase and serum gamma-glutamyl transpeptidase with mild increase of bilirubin level.[]

  • Secondary Polycythemia

    Polycythemia vera, frequently accompanied by thrombocytosis, leukocytosis and enhanced adhesion of blood cells and endothelial cells, have an enhanced risk of thrombosis.[] Increased leucocytosis is seen in more than half of the patients and even may see increased basophils. Increased neutrophil alkaline phosphatase score (NAP).[] .- ) • hypergammaglobulinemia NOS ( D89.2 ) • lymphadenitis NOS ( I88.9 ) • mesenteric lymphadenitis (acute) (chronic) ( I88.0 ) ICD-10-CM Index References • Disease, diseased[]

  • Adult-Onset Still Disease

    Both patients had marked leukocytosis with neutrophil predominance, thrombocytosis, elevated liver enzymes and elevated acute phase rectants.[] In the bone marrow aspiration, we found remarkable hyperplasia and granulocytes of each mature state, without an increase of myeloblasts, the neutrophil alkaline phosphatase[] Liver involvement was observed in all cases, with hepatomegaly in 81.3%, increased liver enzymes in 50.0%, and hypergammaglobulinemia in 68.8%.[]

  • Schimke Immunoosseous Dysplasia

    Familial thrombocytosis is a type of thrombocytosis, a sustained elevation of platelet numbers, which affects the platelet/megakaryocyte lineage and may create a tendency[] AND CHROMOSOME BREAKAGE SYNDROME Lymphoblastic Transformation, Intrinsic Defect in Lymphoid System Deterioration, Progressive Lymphokine Deficiency lymphopenia Lymphopenic Hypergammaglobulinemia[] […] red blood cell mass Failure to thrive Finger syndactyly Generalized hypotonia Global developmental delay Elevated leukocyte alkaline phosphatase Budd-Chiari syndrome Increased[]

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