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28 Possible Causes for Alkaline Phosphatase Increased, Hypergammaglobulinemia, Thrombocytosis

  • Sarcoidosis

    Phosphate and alkaline phosphatase may be increased. LFTs may show derangement. If calcium is elevated then 24-hour urinary collection may demonstrate hypercalciuria.[] Serum protein electrophoresis is an easily accessible and routinely performed examination at diagnosis, in order to search for hypergammaglobulinemia, which is frequently[] phosphatase Hypercalcemia/hypercalciuria/nephrolithiasis Increased serum calcium with no other cause Increased urine calcium Nephrolithiasis, no stone analysis Nephrolithiasis[]

  • Myeloproliferative Disease

    One patient clearly represents a case of RARS with reactive thrombocytosis.[] Abstract A myeloproliferative disorder manifested by thrombocytosis, a high leukocyte alkaline phosphatase (LAP) score and an increased red blood cell mass was found in a[] Decreased erythroid precursor production Extramedullary hematopoiesis Hypercoagulability state Hypergammaglobulinemia Macrocytosis Macrocytosis - no anemia Macrocytosis,[]

  • Lymph Node Hyperplasia

    […] multicentric angiofollicular lymph node hyperplasia had a distinct clinical syndrome characterized by peripheral neuropathy, pseudotumor cerebri, IgA dysproteinemia, and thrombocytosis[] […] of serum alkaline phosphatase and gamma glutamyl transpeptidase activity.[] Severe peripheral neuropathy usually occurs in the setting of multicentric, plasma cell-type disease with hypergammaglobulinemia and is often responsive to immunosuppressive[]

  • Secondary Amyloidosis

    Thrombocytosis is a diagnostic clue and occurs in 10%. Reduced renal function is present at diagnosis in 50% of patients.[] The median SAA concentration in these patients was 51 mg per liter, a finding that is consistent with increased production of alkaline phosphatase as an acute-phase reactant[] Other pathological blood parameters include polyclonal hypergammaglobulinemia, which is attributed to the underlying inflammatory process, and increased serum amyloid A precursor[]

  • Chronic Eosinophilic Leukemia

    , non-Hodgkin's lymphoma, ALL, mastocytosis) (3) acute myeloid leukemia (AML) (4) myelodysplastic disorders (5) other myeloproliferative disorders (polycythemia, primary thrombocytosis[] The activity of granulocyte alkaline phosphatase is increased ( 100 U) in patients with CEL-NOS. 5.[] .— Eosinophilic fasciitis (EF) is characterized by sclerodermalike changes associated with peripheral blood eosinophilia, hypergammaglobulinemia, and an elevated erythrocyte[]

  • Polymyalgia Rheumatica

    Anemia of chronic disease, leukocytosis, reactive thrombocytosis, and decreased albumin are also common. Alkaline phosphatase and hepatic enzymes may be elevated.[] Platelet counts are often increased. • Liver function tests reveal normal transaminase enzyme levels. Alkaline phosphatase may be mildly increased.[] Other laboratory signs of inflammation may include: thrombocytosis, leukocytosis, anemia, hypoalbuminemia, polyclonal hypergammaglobulinemia, and an elevated ferritin.[]

  • Hereditary Spherocytosis

    It also results in leukocytosis and thrombocytosis. On peripheral blood smear, spherocytes are unchanged or may even increase.[] […] and basophils are commonly seen, neutrophil alkaline phosphatase positive rate is 1%, score 2.[] Second, hypergammaglobulinemia may arise when specific helper T cells recognize B cells that have processed viral antigens irrespective of the B cell receptor specificity[]

  • Liver Cirrhosis

    Numerous new mutations are becoming of interest in patients with an MPN, especially in patients with essential thrombocytosis and primary myelofibrosis.[] phosphatase (ALP).[] Antimitochondrial antibodies Primary sclerosing cholangitis History of inflammatory bowel disease ANA often ASMA often Autoimmune hepatitis ANA often ASMA often Anti-LKM-1 often Hypergammaglobulinemia[]

  • Rheumatoid Arthritis

    FBC: normochromic, normocytic anaemia and reactive thrombocytosis are common in active disease.[] Abnormal liver function tests commonly manifest a cholestatic pattern with elevated alkaline phosphatase and γ-glutamyl transferase levels that characterize up to 62% of patients[] ., hypergammaglobulinemia and autoantibodies) in the absence of confirmed autoimmune disease ( 38 , 39 ).[]

  • Inflammatory Bowel Disease

    Abnormality of LFTs was defined as an increase in serum aminotransferases (alanine aminotransferase, ALT; aspartate aminotransferase, AST), alkaline phosphatase (ALP), gamma-glutamyl[] She had steatorrhea, abnormal liver enzymes, hypergammaglobulinemia, autoantibody positivity and steatohepatitis in liver biopsy.[]

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