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56 Possible Causes for Alkaline Phosphatase Increased, Incidence of Hepatocellular Carcinoma Increased

  • Cholelithiasis

    The incidence of ICC is relatively low but increasing worldwide [ 4, 5 ]. The risk factors for ICC are complex.[bmccancer.biomedcentral.com] Patients with increased CBD dilatation more than 5 mm showed statistically significant increases in alkaline phosphatase and gamma-glutamyltransferase.[ncbi.nlm.nih.gov] […] in serum bilirubin concentration, alkaline phosphatase activity, or aspartate transaminase activity.[link.springer.com]

  • Hepatocellular Carcinoma

    The incidence of hepatocellular carcinoma increased with serum HBV DNA level at study entry in a dose-response relationship ranging from 108 per 100,000 person-years for an[ncbi.nlm.nih.gov] Rarely, hemoperitoneum in a cirrhotic patient may shine the light on HCC after a sudden increase in alkaline phosphatase and aspartate transaminase/alanine transaminase levels[docksci.com] […] in gamma-glutamyl transpeptidase/alkaline phosphatase in non-cirrhotic patients( 45, 52 ).[doi.org]

  • Liver Cirrhosis

    El-Serag HB, Davila JA, Petersen NJ, McGlynn KA (2003) The continuing increase in the incidence of hepatocellular carcinoma in the United States: an update.[doi.org] phosphatase (ALP).[qi.quintessenz.de] El-Serag HB (2012) Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology 142 : 1264–1273. [ PMC free article ] [ PubMed ] [ Google Scholar ] 2.[ncbi.nlm.nih.gov]

  • Hemochromatosis

    Approximately 6 percent of patients with hereditary hemochromatosis and cirrhosis develop hepatocellular carcinoma; this represents a 20-fold increased lifetime risk over[aafp.org] C 14, 20 AASLD and IDI vary* Hereditary hemochromatosis is associated with malignancies, particularly hepatocellular carcinoma.[aafp.org] […] the general population and a 4 percent annual incidence rate. 3 The mechanism for increased risk is the effect of excess iron in promoting oxidative DNA damage and free radical[aafp.org]

  • Bone Metastasis

    Increased incidence of bone metastases in hepatocellular carcinoma. Eur J Gastroenterol Hepatol 2001; 13:1083 –1088 [Google Scholar] 9.[ajronline.org] Laboratory investigations are of limited value, but will often demonstrate increased serum calcium and alkaline phosphatase 1,3 .[radiopaedia.org] Laboratory investigations are of limited value, but will often demonstrate increased serum calcium and alkaline phosphatase 1,3.[radiopaedia.org]

  • Cholestasis

    Hepatocellular carcinoma, once a relatively uncommon tumor, has been increasing in incidence since the 1990s because of its association with hepatitis C–induced cirrhosis.[clevelandclinicmeded.com] In most PBC patients (95%), the level of bone-specific alkaline phosphatase was above the normal range, indicating increased bone formation.[ncbi.nlm.nih.gov] […] level of conjugated bilirubin, which is a waste product of the liver an increased level of liver enzymes an increased level of alkaline phosphatase Any of these may indicate[healthline.com]

  • Macronodular Cirrhosis

    Pearls and Other Issues Hepatocellular Carcinoma HCC is the most common primary cancer in the liver, and its incidence is increasing [33].[ncbi.nlm.nih.gov] Diagnostic tests include abnormal liver function studies, including elevations in alkaline phosphatase, aminotransferase, and alanine aminotransferase.[medical-dictionary.thefreedictionary.com] Protein metabolism tests show decreased total protein, decreased albumin, and increased globulin.[medical-dictionary.thefreedictionary.com]

  • Viral Hepatitis

    PURPOSE: Liver cancer (hepatocellular carcinoma (HCC)) incidence and mortality rates are increasing in the United States.[ncbi.nlm.nih.gov] Hepatosplenomegaly and laboratory evidence of mild to moderate hepatic dysfunction are the predominant features, with increased aminotransferases and alkaline phosphatase[doi.org] Alkaline phosphatase (ALP) – an enzyme related to the bile ducts but also found in other tissues throughout the body.[labtestsonline.org]

  • Primary Sclerosing Cholangitis

    Hepatocellular carcinoma, once a relatively uncommon tumor, has been increasing in incidence since the 1990s because of its association with hepatitis C–induced cirrhosis.[clevelandclinicmeded.com] Liver function tests are usually abnormal (increased serum alkaline phosphatase (ALP) most commonly) and the bilirubin level can be raised with biliary obstruction.[royalfree.nhs.uk] Serum alkaline phosphatase levels tend to increase 3-5 times than normal.[symptoma.com]

  • Secondary Sclerosing Cholangitis

    Hepatocellular carcinoma, once a relatively uncommon tumor, has been increasing in incidence since the 1990s because of its association with hepatitis C–induced cirrhosis.[clevelandclinicmeded.com] Laboratory tests Increased serum alkaline phosphatase, transaminase, bilirubin and IgM. Mitochondrial antibodies: rarely present.[meddean.luc.edu] Diagnostic criteria include an increased serum alkaline phosphatase level that persists for more than 6 months, cholangiographic findings of bile-duct strictures detected[blogs.nejm.org]

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