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430 Possible Causes for Alkaline Phosphatase Increased, Iron Increased

  • Chronic Alcoholism

    Coexisting iron accumulation or chronic hepatitis C increases risk of hepatocellular carcinoma.[merckmanuals.com] Other factors that may trigger type 1 PCT include oestrogen, iron and viral infections (especially hepatitis C).[dermnetnz.org] A diet high in unsaturated fat increases susceptibility, as does obesity.[merckmanuals.com]

  • Hemochromatosis

    Recent studies have shown an increased concentration of redox-active iron in plasma in patients with increased transferrin saturation.[ncbi.nlm.nih.gov] DISCUSSION: In the placenta of NH, increases in expressions of TFR1, transferrin, and ferritin of which those of TFR1 were especially marked, reflect increased iron influx[ncbi.nlm.nih.gov] BACKGROUND: Hereditary hemochromatosis is a disorder of iron metabolism characterized by increased iron absorption.HFE gene mutations C282Y and H63D are responsible for the[ncbi.nlm.nih.gov]

  • Liver Failure

    Screening and detection tests include: Alanine aminotransferase (ALT) – an enzyme found mainly in the liver; best test to detect hepatitis Alkaline phosphatase (ALP) – an[labtestsonline.org] Serum ferritin levels are frequently elevated, while iron and iron-binding capacity are normal ( 42 , 130 ).[care.diabetesjournals.org] […] in serum IgG, and normal or only slightly elevated alkaline phosphatase.[nature.com]

  • Portal Cirrhosis

    Laennec's cirrhosis, also known as portal cirrhosis, alcoholic cirrhosis, fatty cirrhosis, or atrophic cirrhosis, [1] is named after René Laennec, [2] a French physician and the inventor of the stethoscope. It is a disease of the liver in which the normal lobular architecture is lost, with fibrosis (scarring) and later[…][en.wikipedia.org]

  • Viral Hepatitis

    Hepatosplenomegaly and laboratory evidence of mild to moderate hepatic dysfunction are the predominant features, with increased aminotransferases and alkaline phosphatase[doi.org] Alkaline phosphatase (ALP) – an enzyme related to the bile ducts but also found in other tissues throughout the body.[labtestsonline.org] The ALP test is often increased when bile ducts are blocked but may also be increased with bone disorders.[labtestsonline.org]

  • Vitamin D Deficiency

    Juvenile Paget's disease (JPD) is a rare heritable osteopathy characterized biochemically by markedly increased serum alkaline phosphatase (ALP) activity emanating from generalized[ncbi.nlm.nih.gov] Low PTH is correlated with increased cardiac iron.[ncbi.nlm.nih.gov] Laboratory test showed severe hypocalcemia, elevated alkaline phosphatase, normal serum phosphorous, decreased 25(OH) cholecalciferol, increased intact parathyroid hormone[ncbi.nlm.nih.gov]

  • Pregnancy

    There is no evidence that iron supplementation increases placental malaria. For some outcomes heterogeneity was higher than 50%.[ncbi.nlm.nih.gov] Iron requirements increase notably during the second half of pregnancy because of the expansion of the red blood cell mass and the transfer of increasing amounts of iron to[doi.org] It should also be noted that vitamin C increases iron absorption, meaning that iron-rich foods (or an iron-fortified supplement) is best taken with orange juice or tomato[ideafit.com]

  • Third Trimester Pregnancy

    This trimester still calls for higher levels of iron and protein.[ohbabynutrition.com] During the last trimester of pregnancy it becomes even more important as your body will increase the supply of blood to the placenta.[onlymyhealth.com] In fact the amount of blood increases by 50%. No wonder so many women experience low iron counts, also those eating an omnivorous diet rich in meat.[kyraskitchen.com]

  • Liver Cirrhosis

    phosphatase (ALP).[qi.quintessenz.de] Iron absorption can be increased if iron stores are depleted (usually through blood loss), and in genetically normal people absorption decreases with iron overload 1, 2 (usually[oadoi.org] […] bilirubin (without increase in alkaline phosphatase) (See web-based course on liver function test abnormalities .)[hiv.va.gov]

  • Sepsis

    Three days after initiation of ECMO, the patient developed jaundice, with increase of bilirubin, Gamma-glutamyltransferase and Alkaline phosphatase, without elevation of alanine[ncbi.nlm.nih.gov] Iron overload states are known to increase patient susceptibility to infections caused by lower virulence bacteria lacking sophisticated iron metabolism pathways, for example[ncbi.nlm.nih.gov] The literature concerning the role of iron in microbe-host interaction and the increased susceptibility to infection of patients with hemochromatosis is reviewed.[tandfonline.com]

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