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76 Possible Causes for Alkaline Phosphatase Increased, Macrocytosis

  • Malabsorption Syndrome

    Hypocalcemia, hypophosphatemia, increased alkaline phosphatase - Vitamin D malabsorption 5. Stool examination for fat, ova or cysts. Special Tests: A.[histopathology-india.net] […] or low albumin ; which shows a high correlation for the presence of an organic disease. [9] [10] In this setting, microcytic anaemia usually implies iron deficiency and macrocytosis[en.wikipedia.org]

  • Chronic Alcoholism

    Alcohol is a common cause of macrocytosis, with a mean corpuscular volume (MCV) of 100-110 fL seen in a majority of patients.[symptoma.com] Alcoholism can also cause mild macrocytosis independent of folate deficiency, due to a direct effect on the bone marrow (common: 90% of alcoholics have MCV of 100-110 even[errolozdalga.com] In chronic alcoholism, macrocytosis, thrombocytopenia, prolonged PT, elevated GGT, hyperuricaemia or hypertriglyceridaemia may be found.[rcpa.edu.au]

  • Multiple Myeloma

    , Robert A. Kyle , Ruth M. Pfeiffer , Jerry A. Katzmann , Neil E. Caporaso , Richard B. Hayes , Angela Dispenzieri , Shaji Kumar , Raynell J. Clark , Dalsu Baris , Robert Hoover and S. Vincent Rajkumar Blood 2009 113:5412-5417; doi: Abstract Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant[…][doi.org]

  • Total Parenteral Nutrition

    Under this treatment, serum total bilirubin was significantly decreased at 3 months, total cholesterol was significantly decreased at 2 months, and alkaline phosphatase (ALP[ncbi.nlm.nih.gov] She manifested lassitude of the legs, discoloration of the nail beds, and macrocytosis.[ncbi.nlm.nih.gov] Liver dysfunction may be transient, evidenced by increased transaminases, bilirubin, and alkaline phosphatase; it commonly occurs when TPN is started.[msdmanuals.com]

  • Cardiac Cirrhosis

    Hematologic Abnormalities Anemia: hypersplenism, hemolysis, Iron deficiency, Folate deficiency Macrocytosis Neutropenia[slideshare.net] phosphatase was mostly normal or only slightly increased Most of the other liver diseases are associated with elevated serum alkaline phosphatase, which can also take this[healthfrom.com] FBC: occult bleeding may produce anaemia; hypersplenism may cause thrombocytopenia; macrocytosis can suggest alcohol abuse.[patient.info]

  • Refractory Megaloblastic Anemia

    RBC numbers (Hb/Hct) -May see nucleated RBCs in peripheral blood Elevated Leukocyte Alkaline Phosphatase (LAP) score Increased WBC and/or platelet counts in 40-60% of patients[brainscape.com] Nonalcoholic liver disease and hypothyroidism account for a substantial portion of macrocytosis.[aafp.org] […] acid and alkaline phosphatase levels – Decreased. · Serum methylmalonate and homocystein levels - Vitamin B-12 is needed for conversion of methylmalonate to Succinyl CoA[sites.google.com]

  • Wilson Disease

    phosphatase/total bilirubin 4, and an increase in serum total copper levels.[dx.doi.org] Macrocytosis, poor liver synthetic function, and low serum alkaline phosphatase led to the diagnosis.[ncbi.nlm.nih.gov] Serum activity of aminotransferases is only moderately increased, and serum concentration of alkaline phosphatase is normal or extremely low.[ncbi.nlm.nih.gov]

  • Fatty Liver

    Blood levels of alkaline phosphatase may become elevated in NAFLD. Sometimes ferritin level is elevated as well.[docsopinion.com] Macrocytosis is commonly seen in all patients with fatty liver and hence it is almost 75% specific.[symptoma.com] Macrocytosis (increased mean cell volume) is common in patients with ALD, with a low sensitivity (27%-52%) and a high specificity (85%-91%).[emedicine.com]

  • Hepatitis B

    Peripheral blood examination revealed anemia, macrocytosis and severe thrombocytopenia.[ncbi.nlm.nih.gov] Serum bilirubin levels seldom increase above 10 mg/dL, the alkaline phosphatase level and prothrombin time are usually normal or mildly elevated (e.g., 1 to 3 seconds), and[clevelandclinicmeded.com] Biochemically, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels can increase to between 500 to 5000 U/L and fall after the acute phase of infection[clevelandclinicmeded.com]

  • Liver Cirrhosis

    phosphatase (ALP).[qi.quintessenz.de] FBC: occult bleeding may produce anaemia; hypersplenism may cause thrombocytopenia; macrocytosis can suggest alcohol abuse.[patient.info] […] bilirubin (without increase in alkaline phosphatase) (See web-based course on liver function test abnormalities .)[hiv.va.gov]

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