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1,201 Possible Causes for Alkaline Phosphatase Increased, Mutation in the Tight Junction Protein 2 Gene

  • Intrahepatic Cholestasis

    The raise at various degrees of serum bilirubin, alkaline phosphatase, and gamma-glutamyl transpeptidase, with or without increased transaminases levels, are common hematochemical[ncbi.nlm.nih.gov] Patients with a confirmed ABCB11 or tight junction protein 2 gene mutation (n 7) had a minimally detectable THBA proportion (0.23-2.99% of total BAs).[ncbi.nlm.nih.gov] An increase in the frequency of MSAF was also associated with higher serum levels at diagnosis of alanine transaminase, alkaline phosphatase and direct bilirubin.[ncbi.nlm.nih.gov]

  • Progressive Familial Intrahepatic Cholestasis

    She presented with jaundice, pruritus, and increased bilirubin levels, together with elevated gamma glutamyl transferase and alkaline phosphatase levels.[ncbi.nlm.nih.gov] It results from mutations in the TJP2 gene, which is responsible for the production of the tight junction protein 2, also known as zona occludens 2 (ZO-2).[symptoma.com] PFIC4 PFIC4 is a recently described genetic mutation involving the TJP2 gene that encodes for the tight junction protein 2[ 3 ].[wjgnet.com]

  • Vitamin D Deficiency

    Juvenile Paget's disease (JPD) is a rare heritable osteopathy characterized biochemically by markedly increased serum alkaline phosphatase (ALP) activity emanating from generalized[ncbi.nlm.nih.gov] Laboratory test showed severe hypocalcemia, elevated alkaline phosphatase, normal serum phosphorous, decreased 25(OH) cholecalciferol, increased intact parathyroid hormone[ncbi.nlm.nih.gov] Serum phosphate usually decreases, and serum alkaline phosphatase usually increases. Serum PTH may be normal or elevated.[merckmanuals.com]

    Missing: Mutation in the Tight Junction Protein 2 Gene
  • Menopause

    The serum levels of calcium, osteocalcin, and alkaline phosphatase and osteoblast density in the tibia were increased, but the density of osteoclast was decreased in OVX rats[ncbi.nlm.nih.gov]

    Missing: Mutation in the Tight Junction Protein 2 Gene
  • Cholelithiasis

    Patients with increased CBD dilatation more than 5 mm showed statistically significant increases in alkaline phosphatase and gamma-glutamyltransferase.[ncbi.nlm.nih.gov] […] in serum bilirubin concentration, alkaline phosphatase activity, or aspartate transaminase activity.[link.springer.com] CONCLUSIONS: The incidence of cholelithiasis was not increased due to subtotal gastrectomy without vagotomy, but the incidence was higher after Billoth-II compared to Billoth-I[ncbi.nlm.nih.gov]

    Missing: Mutation in the Tight Junction Protein 2 Gene
  • Fracture

    Ann Anat. 2018 Mar;216:120-124. doi: 10.1016/j.aanat.2017.12.005. Epub 2018 Jan 1. Author information 1 Studio Fonzar, Strada dei Tigli, 54, 33030 Campoformido, UD, Italy. Electronic address: federica.fonzar@gmail.com. 2 Department of Stomatology, Universitat de València (Spain) Clínica Odontológica, Calle Gascó Oliag, 1, 46010[…][ncbi.nlm.nih.gov]

    Missing: Mutation in the Tight Junction Protein 2 Gene
  • Pregnancy

    Pregnancy in patients with end-stage renal disease is rare, with a paucity of management guidelines in the literature. Various hemodialysis (HD) and peritoneal dialysis (PD) protocols have been used to successfully manage pregnancy in this population; however, there is a growing body of evidence that the best[…][ncbi.nlm.nih.gov]

    Missing: Mutation in the Tight Junction Protein 2 Gene
  • Third Trimester Pregnancy

    The concomitant phenomenon of a third trimester pregnancy with a significant degree of pelvic organ prolapse is extremely rare. We report on a patient with pelvic organ prolapse complicating third trimester pregnancy treated by concomitant cesarean hysterectomy and abdominal sacrocolpopexy. A 30-year-old woman,[…][ncbi.nlm.nih.gov]

    Missing: Mutation in the Tight Junction Protein 2 Gene
  • Chronic Alcoholism

    The concept of "structural plasticity" has emerged as a potential mechanism in neurodegenerative and psychiatric diseases such as drug abuse, depression, and dementia. Chronic alcoholism is a progressive neurodegenerative disease while the person continues to abuse alcohol, though clinical and imaging studies show[…][ncbi.nlm.nih.gov]

    Missing: Mutation in the Tight Junction Protein 2 Gene
  • Cholestatic Jaundice

    LFTs : Alkaline phosphatase: considerably increased with either extrahepatic or intrahepatic biliary disease.[patient.info] Tests not found to be useful in differentiation are cholesterol esterase, alkaline phosphatase and prothrombin time.[pediatrics.aappublications.org] The most common diseases associated with raised alkaline phosphatase include: Gallstones causing bile duct obstruction. Pancreatic cancer. Pregnancy. Drugs.[patient.info]

    Missing: Mutation in the Tight Junction Protein 2 Gene

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