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825 Possible Causes for Alkaline Phosphatase Increased, No Muscle Weakness

  • Vitamin D Deficiency

    Apart from the well-known effects on bone metabolism, this condition is also associated with muscle weakness, predominantly of the proximal muscle groups.[ncbi.nlm.nih.gov] Juvenile Paget's disease (JPD) is a rare heritable osteopathy characterized biochemically by markedly increased serum alkaline phosphatase (ALP) activity emanating from generalized[ncbi.nlm.nih.gov] Laboratory test showed severe hypocalcemia, elevated alkaline phosphatase, normal serum phosphorous, decreased 25(OH) cholecalciferol, increased intact parathyroid hormone[ncbi.nlm.nih.gov]

  • Osteomalacia

    He had a gastrectomy for cancer 7 years previously, with severe vitamin D deficiency; parathormone and alkaline phosphatase were increased, with reduced serum and urine calcium[n.neurology.org] Tumour-induced osteomalacia (TIO) is a rare paraneoplastic syndrome usually presenting with bone pain, fracture of bones and muscle weakness.[ncbi.nlm.nih.gov] There causes hypophosphataemia and a raised alkaline phosphatase due to increased osteoblastic activity.[pathology.leedsth.nhs.uk]

  • Graves Disease

    On neurological examination the patient was presented with muscle weakness, muscle atrophy (in face and sternocleidomastoid muscles), features of myotonia and apocamnosis[ncbi.nlm.nih.gov] This case emphasises the importance of considering TPP in patients with acute muscle weakness and the importance of promptly initiating treatment and preventing relapse of[ncbi.nlm.nih.gov] weakness and myopathy • Increased DTR • Increased motor activity • Fatigue Cardiovascular • Tachycardia • Palpitations • Repiratory muscle weakness • Increased RR and HR[physio-pedia.com]

  • Hereditary Hypophosphatemic Rickets with Hypercalciuria

    When there is a deficiency of vitamin D, the amount of phosphorus and calcium in the blood decreases, the activity of alkaline phosphatase increases, the amount of citrates[encyclopedia2.thefreedictionary.com] weakness.[iofbonehealth.org] The characteristic findings in HR are increased alkaline phosphatase, hypophosphataemia, decreased renal phosphorus reabsorption rate and a normal or increased parathyroid[scielo.mec.pt]

  • Apathetic Thyrotoxicosis with Thyrotoxic Crisis

    . 6) Elevated serum alanine aminotransferase ( ALT ) and alkaline phosphatase ( ALP ) levels. 7) Minor increases in serum total and ionized calcium levels. 3.[empendium.com] They may include Being nervous or irritable Mood swings Fatigue or muscle weakness Heat intolerance Trouble sleeping Hand tremors Rapid and irregular heartbeat Frequent bowel[icdlist.com] Nearly 50% develop proximal muscle weakness called thyroid myopathy. Increasing thyroid hormone also can lead to thyroid effects.[mythyroide.blogspot.com]

  • Rickets

    Biochemical test showed obviously increased alkaline phosphatase (ALP) and parathyroid hormone (PTH), mild hypocalcemia and hypophosphatemia.[ncbi.nlm.nih.gov] Adults can experience similar symptoms such as bone pain, muscle weakness and fragile bones that are more prone to fractures.[nhs.uk] Serum alkaline phosphatase decreased and calcium increased similarly in all groups.[ncbi.nlm.nih.gov]

  • Osteogenesis Imperfecta

    Blood calcium, phosphate, albumin, fasting urinary calcium/creatinine ratio, total serum alkaline phosphatase, and bone alkaline phosphatase were obtained at baseline and[ncbi.nlm.nih.gov] In OI Type IV muscle weakness has important functional consequences.[iofbonehealth.org] Levels of biochemical markers of bone metabolism generally were within the reference range, but serum alkaline phosphatase and urinary collagen type I N-telopeptide excretion[ncbi.nlm.nih.gov]

  • Fanconi Renotubular Syndrome

    phosphatase Greatly elevated alkaline phosphatase High serum alkaline phosphatase Increased alkaline phosphatase Increased serum alkaline phosphatase Last updated: 2/27/2017[rarediseases.info.nih.gov] After cessation of ADV and correction of hypophosphatemia with oral phosphorus supplementation, the patient's clinical symptoms, such as bone pain, muscle weakness, and laboratory[ncbi.nlm.nih.gov] Proximal muscle weakness has developed during her follow-up.[ncbi.nlm.nih.gov]

  • Menopause

    Any unexplained tingling that affects one side of the body or is accompanied by muscle weakness warrants immediate medical attention. Read more...[34-menopause-symptoms.com] The serum levels of calcium, osteocalcin, and alkaline phosphatase and osteoblast density in the tibia were increased, but the density of osteoclast was decreased in OVX rats[ncbi.nlm.nih.gov] Up to 50 per cent of women experience stress incontinence (loss of urine caused by weak pelvic floor muscles) that results in leakage after coughing, sneezing, laughing or[thewomens.org.au]

  • X-Linked Hypophosphatemia

    Paricalcitol decreased alkaline phosphatase activity in adults by 21% (no change with placebo, P .04).[ncbi.nlm.nih.gov] Generalized muscle weakness is the most common symptom across all types of familial hypophosphatemia, while myalgia and fatigue are invariably present.[symptoma.com] Bone pains and proximal muscle weakness improve significantly; however, longitudinal growth in children remains unsatisfactory 1.[casereports.bmj.com]

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