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1,480 Possible Causes for Alkaline Phosphatase Increased, Number of B Cells Decreased, Onset of Disease between 25 and 40 Years of Age

  • Chronic Alcoholism

    CONCLUSIONS: AH and AWLD patients display a significantly reduced PB B-cell count, at the expense of decreased numbers of recently produced immature/regulatory B cells and[ncbi.nlm.nih.gov] RESULTS: Patients with AH showed significantly decreased numbers of total PB B lymphocytes (vs. controls and AWLD), at the expense of immature, memory, and, to a lesser extent[ncbi.nlm.nih.gov] The distribution of PB B-cell subsets (immature/regulatory, naïve, CD27(-) and CD27( ) memory B lymphocytes, and circulating plasmablasts of distinct immunoglobulin-Ig-isotypes[ncbi.nlm.nih.gov]

    Missing: Onset of Disease between 25 and 40 Years of Age
  • Sepsis

    Hyperthermic preconditioning of a rat model of peritonitis reduced the severity of infection, prevented a decrease in the number of CD4 lymphocytes and B cells, and decreased[doi.org] Three days after initiation of ECMO, the patient developed jaundice, with increase of bilirubin, Gamma-glutamyltransferase and Alkaline phosphatase, without elevation of alanine[ncbi.nlm.nih.gov] Although ECMO was stopped, bilirubin serum levels were increasing, reaching the peak of 18.41 mg/dL of total and 15.67 mg/dL of direct bilirubin.[ncbi.nlm.nih.gov]

    Missing: Onset of Disease between 25 and 40 Years of Age
  • Infectious Mononucleosis

    Acute IM is associated with high numbers of EBV-infected B cells, which gradually decrease over time ( 38 ).[dx.doi.org] The number of infected B cells decreases over time after the onset of symptoms of primary infection ( 72 ), but these cells are never eliminated entirely. FIG. 1.[doi.org] We, therefore, propose a disease model in which the number of EBV-infected B cells is a critical determinant of risk of EBV-related HL.[dx.doi.org]

    Missing: Onset of Disease between 25 and 40 Years of Age
  • Bone Metastasis

    The number of vessels/tumor area was significantly decreased in shHIF bone metastases compared to parental and shNT bone metastases ( Figure 7A–B ).[ncbi.nlm.nih.gov] Laboratory investigations are of limited value, but will often demonstrate increased serum calcium and alkaline phosphatase 1,3.[radiopaedia.org] Alkaline phosphatase: When the bones dissolve, the levels of alkaline phosphatase or ALP may increase.[cancer.org]

    Missing: Onset of Disease between 25 and 40 Years of Age
  • Multiple Myeloma

    The growing number of malignant plasma cells themselves crowd out other healthy blood cells in the bone marrow, resulting in decreased numbers of red blood cells, white blood[themmrf.org] Hepatic manifestations, observed in 30% of patients, usually consist of liver enlargement, accompanied by isolated increased serum alkaline phosphatase levels, without evidence[ojrd.biomedcentral.com] Organ involvement may include progressive heart failure, nephrotic syndrome and/or renal failure, hepatomegaly and/or an increased level of serum alkaline phosphatase, autonomic[karger.com]

    Missing: Onset of Disease between 25 and 40 Years of Age
  • Acute Liver Failure

    […] of natural killer cells in hepatitis B virus related acute-on-chronic liver failure, Clinics and Research in Hepatology and Gastroenterology, 40, 5, (605), (2016).[doi.org] phosphatase and renal function biomarkers.[ncbi.nlm.nih.gov] Laboratory tests showed bilirubin of 13.2 mg/dL and marked elevations of serum ALT (1501 U/L) and AST (2800 U/L), with minimal increase in alkaline phosphatase (287 U/L).[livertox.nih.gov]

    Missing: Onset of Disease between 25 and 40 Years of Age
  • Autoimmune Hepatitis

    This decline of IL-2 was associated with decreasing intrahepatic Treg numbers under therapy.[ncbi.nlm.nih.gov] phosphatase – In 80-90% of patients; a sharp increase in the alkaline phosphatase values during the course of autoimmune disease may reflect the development of primary sclerosing[emedicine.com] None of the baseline T and B cell infiltration parameters were associated with the subsequent treatment response in pAIH.[ncbi.nlm.nih.gov]

    Missing: Onset of Disease between 25 and 40 Years of Age
  • Vitamin D Deficiency

    Juvenile Paget's disease (JPD) is a rare heritable osteopathy characterized biochemically by markedly increased serum alkaline phosphatase (ALP) activity emanating from generalized[ncbi.nlm.nih.gov] Laboratory test showed severe hypocalcemia, elevated alkaline phosphatase, normal serum phosphorous, decreased 25(OH) cholecalciferol, increased intact parathyroid hormone[ncbi.nlm.nih.gov] Serum phosphate usually decreases, and serum alkaline phosphatase usually increases. Serum PTH may be normal or elevated.[merckmanuals.com]

    Missing: Number of B Cells Decreased Onset of Disease between 25 and 40 Years of Age
  • Gaucher Disease

    Skewing of CD4 and CD8 T cell numbers resulting in lower CD4/CD8 ratio and an increase in overall T cell activation were observed.[ncbi.nlm.nih.gov] A decrease in the overall B cells and an increase in NK and NKT cells were noted in the GD patients compared to controls.[ncbi.nlm.nih.gov]

    Missing: Onset of Disease between 25 and 40 Years of Age
  • Wilson Disease

    Onset is slow and begins between 11 and 25 years of age. Signs and Symptoms In about 40 to 50% of patients, the disease first affects the central nervous system (CNS).[diagnose-me.com] phosphatase/total bilirubin 4, and an increase in serum total copper levels.[wjgnet.com] Serum activity of aminotransferases is only moderately increased, and serum concentration of alkaline phosphatase is normal or extremely low.[ncbi.nlm.nih.gov]

    Missing: Number of B Cells Decreased

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