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16 Possible Causes for Alkaline Phosphatase Increased, Osteopenia and Osteoporosis, Retinal Hemorrhage

  • Multiple Myeloma

    Sludging in the capillaries resulting in purpura, papilledema, central nervous system symptoms, retinal hemorrhage, or coronary ischemia can occur.[symptoma.com] Bisphosphonates (alendronate or zoledronic acid) have been shown to improve bone mineral density in MGUS patients with osteopenia/osteoporosis or osteoporotic fractures (grade[doi.org] Purpura, retinal hemorrhage, papilledema, coronary ischemia, seizures, and confusion may occur as a result of hyperviscosity syndrome.[emedicine.medscape.com]

  • Ulcerative Colitis

    Three months after the injection, retinal hemorrhages were not detectable.[ncbi.nlm.nih.gov] Some corticosteroid medications taken to treat ulcerative colitis symptoms can cause osteoporosis—the loss of bone osteopenia—low bone density Health care providers will monitor[niddk.nih.gov] He received sustained-release intravitreal dexamethasone, which led to the resolution of retinal hemorrhage, optic disc swelling, and cotton-wool spots.[ncbi.nlm.nih.gov]

  • Menkes Disease

    The investigation showed cerebrospinal fluid, red and white blood cell count, platelet count, sodium, potassium, creatinine, alkaline phosphatase, gamma-GT, alanine and aspartate[scielo.br] Menkes disease may mimic non-accidental trauma ( NAT ) with retinal hemorrhage and bilateral subdural hematomas.[radiopaedia.org] Differential Diagnosis MNK may mimic non-accidental trauma (NAT) with retinal hemorrhage and bilateral subdural hematomas.[smartspeechtherapy.com]

  • Sarcoidosis

    Phosphate and alkaline phosphatase may be increased. LFTs may show derangement. If calcium is elevated then 24-hour urinary collection may demonstrate hypercalciuria.[patient.info] Branch retinal vein occlusion in a child with ocular sarcoidosis.[ncbi.nlm.nih.gov] Furthermore, abnormal calcium metabolism may lead to osteopenia and osteoporosis.[dx.doi.org]

  • Pseudoxanthoma Elasticum

    ABCC6 mutant cells additionally had increased expression and activity of tissue-nonspecific alkaline phosphatase (TNAP), an enzyme that degrades pyrophosphate, a major inhibitor[ncbi.nlm.nih.gov] The potential for retinal hemorrhage has led to recommendations for limitations of contact sports or other activities that might facilitate eye trauma.[ncbi.nlm.nih.gov] Calcium intake should be at the RDA levels and supplementation avoided unless dietary intake is known to be inadequate, or there is evidence of osteopenia or osteoporosis.[hypermobility.org]

  • Filgrastim

    […] and blood alkaline phosphatase increased With AML ( 2% difference in incidence) are epistaxis, back pain, pain in extremity, erythema, and rash maculo-papular With nonmyeloid[sandoz.com] This was complicated by marked hyperleukocytosis and retinal hemorrhages. The patient's symptoms improved gradually following leukopheresis.[ncbi.nlm.nih.gov] osteopenia, as defined by abnormal bone densities, was found in half of studied patients. 3 Some of the children have benefited from bisphosphonate therapy. 4 For patients[bloodjournal.org]

  • Acquired Immunodeficiency Syndrome

    Patients with hepatic penicilliosis have fever, abdominal pain, hepatomegaly , and a marked increase in serum alkaline phosphatase levels.[cdc.gov] […] associated with retinal vasculitis, hemorrhage, and necrosis).[cdc.gov] […] and osteoporosis (reduced bone mineral density; BMD) in HIV-infected patients and the role of antiretroviral therapy (ART) varies in the literature.[doi.org]

  • Craniofacial Dysplasia-Osteopenia Syndrome

    Creatine kinase and serum alkaline phosphatase may be increased and muscle histology shows small, atrophic fibers with increased fibrosis and considerable variations in fiber[disorders.eyes.arizona.edu] hemorrhage, vision loss due to damage and neovasc), skin (plucked chicken skin/xanthoma like papule in flexors), and vascular (premature vascular disease) elastosis perforans[quizlet.com] Individuals with cleidocranial dysplasia often have decreased bone density (osteopenia) and may develop osteoporosis , a condition that makes bones progressively more brittle[ghr.nlm.nih.gov]

  • Erdheim-Chester Disease

    Laboratory findings of various ECD patients may include elevated erythrocyte sedimentation rates (ESR), increased levels of alkaline phosphatase and increased levels of C-reactive[doi.org] hemorrhagic uveitis and exudative r IMCRJ Dove Medical Press Langerhans cell histiocytosis with hemorrhagic uveitis and exudative retinal detachment Ranju Kharel Sitaula,[histio.org] In women with anorexia nervosa, we have found that low leptin levels are associated with osteopenia and osteoporosis (1) .[annals.org]

  • Topiramate

    […] versus 2% placebo), markedly increased serum alkaline phosphatase (3% topiramate versus 1% placebo), and decreased serum potassium (0.4 % topiramate versus 0.1 % placebo)[dailymed.nlm.nih.gov] Supplements The following supplements have been found to have a wide range of adverse ocular side effects ranging from dry eye to retinal hemorrhages and transient visual[web.archive.org] , osteomalacia, or osteoporosis (conditions in which the bones are soft or brittle and may break easily); diabetes; glaucoma (a type of eye disease); any disease that affects[web.archive.org]

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