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508 Possible Causes for Alkaline Phosphatase Increased, Pruritus

  • Primary Biliary Cirrhosis

    We had also observed in the other three groups of patients that the average of the values of γ-glutamyl transpeptidase and alkaline phosphatase increases with the increase[] Intense pruritus can be itself an indication to liver transplantation, in extreme cases leading to suicide.[] alkaline phosphatase levels results in an improvement of cholestasis as compared to placebo, with a parallel decrease of aminotransferases and immunoglobulin M, as well as[]

  • Intrahepatic Cholestasis

    The raise at various degrees of serum bilirubin, alkaline phosphatase, and gamma-glutamyl transpeptidase, with or without increased transaminases levels, are common hematochemical[] Pruritus was diminished from a mean of 4 (range 4-4) preoperatively to a mean of 2 (4-0).[] An increase in the frequency of MSAF was also associated with higher serum levels at diagnosis of alanine transaminase, alkaline phosphatase and direct bilirubin.[]

  • Cholestasis

    In most PBC patients (95%), the level of bone-specific alkaline phosphatase was above the normal range, indicating increased bone formation.[] All three patients showed significant improvement in pruritus, with none or minimal pruritus in one patient with primary biliary cirrhosis.[] On admission, concentrations of alkaline phosphatase (ALP) and γ-glutamil transpeptidase were increased. Aminotransferases and bone ALP were normal.[]

  • Progressive Familial Intrahepatic Cholestasis

    She presented with jaundice, pruritus, and increased bilirubin levels, together with elevated gamma glutamyl transferase and alkaline phosphatase levels.[] Abstract Biliary diversion offers a potential option for intractable pruritus in children with chronic cholestatic disorders.[] phosphatase are profoundly high, 3) serum cholesterol is normal or low, and 4) serum bile acid concentration is increased.[]

  • Primary Sclerosing Cholangitis

    Liver function tests are usually abnormal (increased serum alkaline phosphatase (ALP) most commonly) and the bilirubin level can be raised with biliary obstruction.[] Abstract Primary sclerosing cholangitis (PSC) is a chronic inflammatory disease of bile ducts..Patients with PSC usually presents with fatigue, jaundice and pruritus.[] Serum alkaline phosphatase levels tend to increase 3-5 times than normal.[]

  • Recurrent Jaundice of Pregnancy

    […] in twin pregnancies Alkaline phosphatase levels rise three- to fourfold because of placental production Clotting factors I, II, V, VII, VIII, X, and XII Ceruloplasmin level[] […] cholestasis of pregnancy intrahepatic cholestasis with centrilobular bile staining without inflammatory cells or proliferation of mesenchymal cells; clinically characterized by pruritus[] These are deposited within the skin, causing intense pruritus.[]

  • Systemic Mastocytosis

    In multivariate analysis of all patients, an increased spleen volume 450 ml (hazard ratio (HR), 5.2; 95% confidence interval (CI), (2.1-13.0); P 0.003) and an elevated alkaline[] Cladarabine chemotherapy and adjuvant antihistaminic agent alleviated the pruritus.[] Preoperative laboratory investigations were normal, except for moderate anemia (hemoglobin 99 g/L), increased alkaline phosphatase (196 U/L, normal 36-108 U/L), and decreased[]

  • Drug-induced Cholestatic Hepatitis

    […] of 1.5 N of alkaline phosphatase associated with an increase of ALT or AST and/or total bilirubin in patients with or without symptoms [ 15 , 16 ].[] References Bunchorntavakul C, Reddy KR: Pruritus in chronic cholestatic liver disease. Clin Liver Dis 2012;16: 331–346.[] […] in alkaline phosphatase (ALP) greater than 2 times the upper limit of normal (ULN) and/or an alanine aminotransferase (ALT)/ALP ratio of less than 2.[ 3 ] One can also differentiate[]

  • Secondary Biliary Cirrhosis

    increased conjugated bilirubin, increased cholesterol, and increased alkaline phosphatase, and increased GGT; primary biliary cirrhosis and primary sclerosing cholangitis[] SECONDARY BILIARY CI RR H OS I S Symptoms Clinical features · Jaundice · Pruritus · Biliary colics.[] The biochemical blood samples found to have elevated levels of cholesterol, bilirubin, transaminases, alkaline phosphatase.[]

  • Acute Fatty Liver of Pregnancy

    The serum concentrations of transaminase enzymes, bilirubin, and alkaline phosphatase were increased, and a mild coagulopathy was present.[] The pruritus, however, persisted despite the premature delivery of a normal newborn at the 35th week.[] Differential Diagnosis See Acute Hepatitis Hyperemesis Gravidarum Liver transaminases (AST, ALT) may be over 200 IU/L Alkaline Phosphatase may be increased up to twice normal[]

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