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37 Possible Causes for Alkaline Phosphatase Increased, Severely Disproportionate Short Stature

  • Osteogenesis Imperfecta

    Blood calcium, phosphate, albumin, fasting urinary calcium/creatinine ratio, total serum alkaline phosphatase, and bone alkaline phosphatase were obtained at baseline and[ncbi.nlm.nih.gov] Pseudoachondroplasia usually manifests in the 2 nd year of life with ligamentous laxity and tends to develop severe disproportionate short stature.[doi.org] Levels of biochemical markers of bone metabolism generally were within the reference range, but serum alkaline phosphatase and urinary collagen type I N-telopeptide excretion[ncbi.nlm.nih.gov]

  • Growth Failure

    Healing occurs in 2–4 weeks and can be monitored from the lowering of alkaline phosphatase, increasing vitamin D levels and healing on X-rays, but complete reversal of bony[slideplayer.com] A distinctive autosomal recessive syndrome of severe disproportionate short stature with short long bones, brachydactyly, and hypotrichosis in two consanguineous arab families[advbiores.net] The short stature may be either proportionate or disproportionate, severe or mild, and have pre-natal and/or post-natal origin ( 7, 8 ).[frontiersin.org]

  • Skeletal Dysplasia

    As such, severe congenital hypophosphatasia is usually associated with reduced serum concentrations of alkaline phosphatase and increased urinary phosphorylethanolamine.[symptoma.com] Pseudoachondroplasia usually manifests in the 2 nd year of life with ligamentous laxity and tends to develop severe disproportionate short stature.[doi.org] […] form of disproportionate short-limb short stature.[en.wikipedia.org]

  • Cleidocranial Dysplasia

    We investigated a mother and daughter with features of CCD presenting with reduced plasma alkaline phosphatase activity, increased urinary phosphoethanolamine excretion and[ncbi.nlm.nih.gov] The presented case also had severe disproportionate short stature with US/LS of 1.03 and height of 118 cm (SDS of -4.2).[omjournal.org] Delayed exception could be attributed to various other factors like mechanical obstruction, reduced serum alkaline phosphatase levels etc.[ijdr.in]

  • Schwartz-Lelek Syndrome

    phosphatase Increased intracranial pressure Hyperparathyroidism Narrow chest Smooth philtrum Abnormality of neuronal migration Intestinal malrotation Patent ductus arteriosus[mendelian.co] […] coxa vara and disproportionate short stature, abnormal epiphyses and vertebra plana Femoral head ossification not until 5 years Vertebrae are flattened throughout and pear[flinders.edu.au] Serum alkaline phosphatase levels may show a 20-fold increase. Serum acid phosphatase and urinary hydroxyproline and leucine aminopeptidase are also elevated.[rrnursingschool.biz]

  • Acro-Pectoral Syndrome

    phosphatase may be increased Differential Hypophosphatasia (low alkaline phosphatase in serum) Achondroplasia ( no increased bone fragility) Treatment No specific treatment[flinders.edu.au] […] coxa vara and disproportionate short stature, abnormal epiphyses and vertebra plana Femoral head ossification not until 5 years Vertebrae are flattened throughout and pear[flinders.edu.au] phosphatase & urinary hyroxyproline may be increased Hypocalcaemia and hyperphosphataemia Positive calcium balance may be present Differential Polyostotic fibrous dysplasia[flinders.edu.au]

  • Tibia Varum

    […] serum alkaline phosphatase, and increased serum levels of 1,25-dihydroxyvitamin D3.[findzebra.com] The clinical picture is that of a mild achondroplasia and is represented by disproportionate short stature with short limbs but without an obvious rhizomelia, brachydactyly[intechopen.com] The serum alkaline phosphatase concentration was elevated (the average was five times greater than normal).[smw.ch]

  • Sclerosteosis Type 2

    alkaline phosphatase, parathormone, serum calcium, phosphorus, and erythrocyte sedimentation rate can be observed in the laboratory tests, but is not the norm to find these[elsevier.es] Increased bone growth can lead to the bones becoming more brittle and in sever cases can lead to short disproportionate stature, deformed bone growth and increased fractures[powerofthegene.com] Accordingly, increased skeletal alkaline phosphatase, in adults as well as in children, has been reported in this condition ( 10 ).[academic.oup.com]

  • Spondylocarpotarsal Synostosis

    […] in bone alkaline phosphatase and tartrate-resistant acid phosphatase 5b was detected.[ccmbm.com] Ver-tebral involvement, which is usually severe and maycause disproportionally short trunk/stature, is not as-sociated with any rib anomalies.[docslide.com.br] Short-term teriparatide use did not worsen the calcinosis cutis in terms of clinical symptoms and radiological signs, and the atypical femoral fracture healed; however, an increase[ccmbm.com]

  • Boomerang Dysplasia

    Her complete blood counts, serum calcium, serum phosphorous, alkaline phosphatase, thyroid profile, and complete urine analysis were unremarkable.[bmcmedgenet.biomedcentral.com] SCT syndrome is characterized by disproportionate short stature, block vertebrae, scoliosis and lordosis, carpal and tarsal fusion, club feet, hearing loss, dental enamel[ncbi.nlm.nih.gov] She had normal right hip joint but increased medial joint space on left hip joint (Fig. 6f ). Echocardiography was normal.[bmcmedgenet.biomedcentral.com]

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