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55 Possible Causes for Alkaline Phosphatase Increased, Some Patients May Be Clinically Asymptomatic

  • Vitamin D Deficiency

    It is imperative to consider that some patients, such as our patient described in this report, may be previously asymptomatic clinically and on the basis of laboratory findings[ncbi.nlm.nih.gov] Juvenile Paget's disease (JPD) is a rare heritable osteopathy characterized biochemically by markedly increased serum alkaline phosphatase (ALP) activity emanating from generalized[ncbi.nlm.nih.gov] Laboratory test showed severe hypocalcemia, elevated alkaline phosphatase, normal serum phosphorous, decreased 25(OH) cholecalciferol, increased intact parathyroid hormone[ncbi.nlm.nih.gov]

  • Viral Hepatitis

    patients with cirrhosis are asymptomatic, others develop life-threatening complications.[emedicine.medscape.com] Hepatosplenomegaly and laboratory evidence of mild to moderate hepatic dysfunction are the predominant features, with increased aminotransferases and alkaline phosphatase[doi.org] Alkaline phosphatase (ALP) – an enzyme related to the bile ducts but also found in other tissues throughout the body.[labtestsonline.org]

  • Drug-induced Toxic Hepatitis

    […] degree of liver injury may occur in any patient who ingests a drug that is metabolized in the liver.[mdedge.com] , γ-glutamyltransferase (GGT) and alkaline phosphatase ( Table 1 ).[nature.com] Approximately 1.9% of patients taking ciprofloxacin show elevated SGPT levels, 1.7% have elevated SGOT levels, 0.8% have increased alkaline phosphatase levels, and 0.3% have[emedicine.medscape.com]

  • Primary Hyperparathyroidism

    It is imperative to consider that some patients, such as our patient described in this report, may be previously asymptomatic clinically and on the basis of laboratory findings[ncbi.nlm.nih.gov] Serum calcium is increased. Serum phosphorus may be decreased. Serum alkaline phosphatase may be increased. Bone x-ray may show bone reabsorption or fractures.[uclahealth.org] Even asymptomatic PHPT patients display clinical improvement in some symptoms a year following PTx, particularly patients with higher preoperative calcium levels ( 2.6 mmol[link.springer.com]

  • Primary Biliary Cirrhosis

    Clinical description The majority of patients are asymptomatic at diagnosis, however, some patients present with symptoms of fatigue and/or pruritus.[orpha.net] We had also observed in the other three groups of patients that the average of the values of γ-glutamyl transpeptidase and alkaline phosphatase increases with the increase[ncbi.nlm.nih.gov] alkaline phosphatase levels results in an improvement of cholestasis as compared to placebo, with a parallel decrease of aminotransferases and immunoglobulin M, as well as[ncbi.nlm.nih.gov]

  • Drug-induced Cholestatic Hepatitis

    […] degree of liver injury may occur in any patient who ingests a drug that is metabolized in the liver.[mdedge.com] […] of 1.5 N of alkaline phosphatase associated with an increase of ALT or AST and/or total bilirubin in patients with or without symptoms [ 15 , 16 ].[omicsonline.org] […] in alkaline phosphatase (ALP) greater than 2 times the upper limit of normal (ULN) and/or an alanine aminotransferase (ALT)/ALP ratio of less than 2.[ 3 ] One can also differentiate[onlinelibrary.wiley.com]

  • Glycogen Storage Disease due to GLUT2 Deficiency

    Related to Increased sarcoplasmic Ca Myalgia Myoglobinuria : Some patients; With intense exercise Strength: Normal Clinical course: Benign Treatment: Dantrolene may reduce[neuromuscular.wustl.edu] phosphatase Greatly elevated alkaline phosphatase High serum alkaline phosphatase Increased alkaline phosphatase Increased serum alkaline phosphatase Last updated: 2/27/2017[rarediseases.info.nih.gov] Serum levels of calcium were normal, whereas alkaline phosphatase was usually increased.[slideheaven.com]

  • Hepatitis A

    The clinical symptoms vary from person to person, with some patients remaining asymptomatic or suffering from less severe symptoms.[symptoma.com] Alkaline phosphatase activity also rises relatively late in the course of the infection, and tends to parallel serum bilirubin increases.[clinchem.org] Liver enzymes like aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma-glutamyl transferase and lactate dehydrogenase were severely elevated.[ncbi.nlm.nih.gov]

  • Osteomalacia

    The absence of short stature and lower limb deformities in some of these patients suggest a not so intense hypophosphatemia during infancy and childhood (53).[scielo.br] He had a gastrectomy for cancer 7 years previously, with severe vitamin D deficiency; parathormone and alkaline phosphatase were increased, with reduced serum and urine calcium[n.neurology.org] There causes hypophosphataemia and a raised alkaline phosphatase due to increased osteoblastic activity.[pathology.leedsth.nhs.uk]

  • Disseminated Infection with Mycobacterium Avium Complex

    […] and radiologically very like that caused by infection with M tuberculosis, although some patients may be asymptomatic.[thorax.bmj.com] […] men, over half of whom usually have chronic bronchitis and emphysema, old healed tuberculosis, or both. 28-31 The illness presents acutely or subacutely in a way that is clinically[thorax.bmj.com]

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