The offspring will be obligate heterozygotes for the specific mutant allele and unaffected unless the individuals mate is a carrier of a mutant allele.
[dermatologyadvisor.com]
Abstract: Late-onset multiple carboxylase deficiency is characterized clinically by skin rash, alopecia, seizures and ataxia and occasionally by candidiasis and developmental
[deepblue.lib.umich.edu]
Two patients presented in early childhood with (i) alopecia, skin rashs, and dermatitis, (ii) severe hypotonia, ataxia and motor retardation, (iii) frequent episodes of ketoacidosis
[ncbi.nlm.nih.gov]