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28 Possible Causes for Allelic Disorder to Potassium-Aggravated Myotonia, Cold-Induced Muscle Cramps

  • Paramyotonia Congenita

    The sodium channelopathies include five allelic disorders: paramyotoniacongenita (PMC), potassium-aggravated myotonia, hyperkalemic periodic paralysis, hypokalemic periodic[omicsonline.org] Five were interviewed; their symptoms began in early childhood, and included muscle cramping induced by exposure to cold or exertion (both in most cases).[mja.com.au] Myotonia is the result of uncontrolled repetitive muscle fiber discharges, which is a consequence of increased membrane excitability.[omicsonline.org]

  • Hyperkalemic Periodic Paralysis

    A case of atypical hyperkalemic periodic paralysis is reported. The diagnosis was confirmed by hyperkalemic test, cold water test, and differentiation of attack period and rest period by the measurement of motor nerve conduction amplitude. Etio-pathology of this disease is discussed from the view of[…][ncbi.nlm.nih.gov]

    Missing: Cold-Induced Muscle Cramps
  • Autosomal Dominant Myoglobinuria

    Mutations in SCN4A can produce the clinical phenotypes of hyperkalemic and normokalemic periodic paralysis (hyperKPP), paramyoto-nia congenita, and potassium-aggravated myotonia[what-when-how.com] […] dysfunction with exercise intolerance, cramps and acute painful rhabdomyolysis or myoglobinuria (with or without myalgia) induced by fever, fasting or prolonged exercise,[neuroweb.us] Patients with these allelic disorders demonstrate varying degrees of myotonia of eye closure, chewing, swallowing, and gripping of the hands.[what-when-how.com]

  • Myoglobinuria

    Mutations in SCN4A can produce the clinical phenotypes of hyperkalemic and normokalemic periodic paralysis (hyperKPP), paramyoto-nia congenita, and potassium-aggravated myotonia[what-when-how.com] […] dysfunction with exercise intolerance, cramps and acute painful rhabdomyolysis or myoglobinuria (with or without myalgia) induced by fever, fasting or prolonged exercise,[neuroweb.us] Patients with these allelic disorders demonstrate varying degrees of myotonia of eye closure, chewing, swallowing, and gripping of the hands.[what-when-how.com]

  • Muscle Cramp

    Limb muscle cramps lasting 2–3 minutes, induced by exertion and exposure to cold, were noted several times each week and she had recently experienced neck muscle cramps.[jnnp.bmj.com] Initially the cramps were induced by exertion and exposure to cold, but later occurred during rest and sometimes interfered with sleep.[jnnp.bmj.com] His 20 year old daughter (III-17) also had a more than 10 year history of muscle cramps during rest and sleep. Cramps were induced by stretching the affected muscles.[jnnp.bmj.com]

    Missing: Allelic Disorder to Potassium-Aggravated Myotonia
  • Hoyeraal-Hreidarsson Syndrome

    muscle cramps Acute demyelinating polyneuropathy Spontaneous pain sensation Shoulder pain Abnormal nervous system electrophysiology Myelin outfoldings Onion bulb formation[mendelian.co] Decreased number of peripheral myelinated nerve fibers Tetraparesis Progressive distal muscular atrophy Confusion Hypotelorism Paralysis Weight loss Respiratory insufficiency Cold-induced[mendelian.co]

    Missing: Allelic Disorder to Potassium-Aggravated Myotonia
  • Acute Cerebellar Ataxia

    […] dysfunction with exercise intolerance, cramps and acute painful rhabdomyolysis or myoglobinuria (with or without myalgia) induced by fever, fasting or prolonged exercise,[neuroweb.us] […] valproate therapy, cold exposure (carnitine palmitoyltransferase II (CPT II) deficiency or (3) both (LCAD, VLCAD, short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD), and[neuroweb.us] […] acyl-CoA dehydrogenase (LCAD, VLCAD), and trifunctional enzyme deficiencies) or (2) normal muscle strength between attacks with episodes of acute, recurrent, reversible muscle[neuroweb.us]

    Missing: Allelic Disorder to Potassium-Aggravated Myotonia
  • Alcoholic Cerebellar Degeneration

    […] dysfunction with exercise intolerance, cramps and acute painful rhabdomyolysis or myoglobinuria (with or without myalgia) induced by fever, fasting or prolonged exercise,[neuroweb.us] […] valproate therapy, cold exposure (carnitine palmitoyltransferase II (CPT II) deficiency or (3) both (LCAD, VLCAD, short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD), and[neuroweb.us] […] acyl-CoA dehydrogenase (LCAD, VLCAD), and trifunctional enzyme deficiencies) or (2) normal muscle strength between attacks with episodes of acute, recurrent, reversible muscle[neuroweb.us]

    Missing: Allelic Disorder to Potassium-Aggravated Myotonia
  • Glycogen Storage Disease due to Phosphoglycerate Mutase Deficiency

    Mutations in SCN4A can produce the clinical phenotypes of hyperkalemic and normokalemic periodic paralysis (hyperKPP), paramyoto-nia congenita, and potassium-aggravated myotonia[what-when-how.com] Patients with these allelic disorders demonstrate varying degrees of myotonia of eye closure, chewing, swallowing, and gripping of the hands.[what-when-how.com]

    Missing: Cold-Induced Muscle Cramps
  • Adult-Onset Autosomal Recessive Cerebellar Ataxia

    […] dysfunction with exercise intolerance, cramps and acute painful rhabdomyolysis or myoglobinuria (with or without myalgia) induced by fever, fasting or prolonged exercise,[neuroweb.us] […] valproate therapy, cold exposure (carnitine palmitoyltransferase II (CPT II) deficiency or (3) both (LCAD, VLCAD, short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD), and[neuroweb.us] […] acyl-CoA dehydrogenase (LCAD, VLCAD), and trifunctional enzyme deficiencies) or (2) normal muscle strength between attacks with episodes of acute, recurrent, reversible muscle[neuroweb.us]

    Missing: Allelic Disorder to Potassium-Aggravated Myotonia

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