Allodynia: Causes & Reasons

Warning: Do not use in emergencies, if pregnant, if under 18, or as a substitute for a doctor’s advice or diagnosis. Learn more

Possible Causes for Allodynia

Multiple Sclerosis

We used the Mainland-Gart test to analyse binary data (temporal summation, allodynia, treatment preference, adverse events). [bmj.com]

Sativex successfully treats neuropathic pain characterised by allodynia: a randomised, double-blind, placebo-controlled clinical trial. [ncbi.nlm.nih.gov]

We considered allodynia (to dynamic touch or cold) to be present if pain was provoked or worsened by the stimulus and pain intensity after stimulation was ≥ 3. [bmj.com]

Neuropathy

[…] pressure (static allodynia). [practicalpainmanagement.com]

In this study, we found that tamoxifen, a protein kinase C inhibitor, suppressed paclitaxel-, vincristine-, and bortezomib-induced cold and mechanical allodynia in mice. [ncbi.nlm.nih.gov]

[…] temperature, particularly in your feet a burning or sharp pain, usually in the feet feeling pain from something that should not be painful at all, such as a very light touch (allodynia [nhs.uk]

Postherpetic Neuralgia

Allodynia was present in 23 patients (64%). [ncbi.nlm.nih.gov]

Allodynia severity was markedly reduced in both groups during all three trials. [ncbi.nlm.nih.gov]

Outcome measures included the Neuropathy Pain Scale Questionnaire as the primary outcome measure, with the Numeric Pain Scale and total area of allodynia touch sensitivity [ncbi.nlm.nih.gov]

Shoulder-Hand Syndrome

Continuing pain, allodynia, or hyperalgesia disproportionate to the inciting event3. [slideshare.net]

RSD develops after a noxious event which is associated with a spontaneous pain or allodynia or hyperalgesia. [apekshabesekar.com]

QST revealed mechanical allodynia ( P < 0.03) and heat-pain hyperalgesia ( P < 0.04) at the CRPS-affected site. [dx.doi.org]

Reflex Sympathetic Dystrophy

Stellate ganglion block with phenol, local anesthetic, and steroid resulted in long-lasting absence of cold allodynia. [ncbi.nlm.nih.gov]

We present a case of refractory reflex sympathetic dystrophy (RSD) (complex regional pain syndrome, type I) whose symptoms (ongoing pain, allodynia, hyperhydrosis and temperature [ncbi.nlm.nih.gov]

The patient's allodynia and skin lesions improved significantly. However, over time, her initial symptoms reappeared which included skin breakdown. [ncbi.nlm.nih.gov]

Complex Regional Pain Syndrome Type II

Then, in this territory, the intensity of allodynia was dertermined with other thinner monofilaments. [em-consulte.com]

Pain and allodynia in the areas associated with this sensation were alleviated significantly. [ncbi.nlm.nih.gov]

After reconstruction, the causalgia and allodynia disappeared and movement of the fingers recovered during the following 6 months. [ncbi.nlm.nih.gov]

Primary Erythromelalgia

This resulted in complete resolution of both allodynia and hyperalgesia. Dosage was increased to 1.8 mcg/die. [painmatters.wordpress.com]

Seven patients had brush-evoked allodynia and fourteen had punctate hyperalgesia inside or close to the symptomatic areas in their feet. [ncbi.nlm.nih.gov]

Conclusion: It is promising to see that severe pain including burning pain, hyperalgesia and allodynia, as well as swelling, redness and excessive warmth of lower legs and [painmatters.wordpress.com]

Fibrodysplasia Ossificans Progressiva

This disease presents at birth typically with infants having deformed big toes and/or thumbs, or lumps on their toes or fingers. Sometimes a joint may simple be missing. Overgrowths of the rib cage result in decreased expansion and growth of lungs resulting in respiratory compromise. The disease progresses from[…] [symptoma.com]

Trigeminal Neuropathy

Preoperative allodynia or dysesthesia was resolved in six patients and greatly reduced in four. [ncbi.nlm.nih.gov]

PPTTN was consistently accompanied by trigeminal sensory abnormalities (96%) that were mostly allodynia, hyperor hypoalgesia, and only 1% of the PPTTN cases had anesthesia [ncbi.nlm.nih.gov]

These patients often present with complex changes of facial sensibility in the form of dysesthesia, hyperalgesia, and allodynia. [ncbi.nlm.nih.gov]

Peripheral Sensory Neuropathy

ANSWER QUESTION: Define "allodynia". ANSWER [courses.washington.edu]

[…] exhibiting sensory deficits such as loss of pinprick sensitivity; thermal hyperalgesia, with increased thermal pain sensitivity; and mechanical hyperalgesia, characterized by allodynia [clinicalpainadvisor.com]

Pain receptors can become oversensitised resulting in spontaneous burning pain, discomfort to light touch (allodynia) and hypersensitivity to pain (hyperalgesia). [nni.com.sg]

Cervico-Occipital Neuralgia

[…] attacks lasting from a few seconds to minutes severe in intensity shooting, stabbing or sharp in quality Pain is associated with both of the following: dysaesthesia and/or allodynia [ichd-3.org]

The development of cutaneous allodynia during a migraine attack. [pathos-journal.com]

The Effects of Greater Occiptal Nerve Block and Trigger Point Injection on Brush Allodynia and Pain in Migraine. Headache 205; 45: 350-354. 29) Kanai A et al. [pathos-journal.com]

Peripheral Motor Neuropathy

Pain receptors can become oversensitised resulting in spontaneous burning pain, discomfort to light touch (allodynia) and hypersensitivity to pain (hyperalgesia). [nni.com.sg]

[…] dysesthesias (45%), or spontaneous burning, cramping, or aching pain (40%) that is usually symmetric, begins peripherally and progresses proximally. 1 Patients often report allodynia [hematology.org]

Ciguatera Poisoning

Thirty-six hours after consuming two reef fish they developed paraesthesia of the mouth, hands and feet, myalgia, pruritis and cold allodynia. [ncbi.nlm.nih.gov]

Neurological symptoms commonly include cold allodynia (dysaesthesia when touching cold water or objects), generalised paraesthesia with numbness around the lips and tongue [nzma.org.nz]

[…] and hallucinations may also occur which the patient feeling a metallic or peppery taste in the mouth, and reversal of hot and cold sensations which is a condition known as allodynia [leisurepro.com]

Ischemic Peripheral Neuropathy

The changes noted in the severity of pain and allodynia are noted in Table 3. [jdmdonline.biomedcentral.com]

Sensory loss may be mild and overshadowed by allodynia (all stimuli producing pain), hyperalgesia and hyperpathia (delayed perception, summation and painful aftersensation [physio-pedia.com]

It is characterized in humans by spontaneous pain, allodynia (the experience of non-noxious stimuli as painful), and causalgia (constant burning pain). [practicalpainmanagement.com]

Drug-Induced Peripheral Neuropathy

Patients can present with symmetric, distal, length-dependent, “stocking-glove” distribution of painful paresthesia, dysesthesia, cold sensitivity, allodynia, tingling, and [clinicalgate.com]

Patients may also notice that things that are not normally painful are now painful (called allodynia). [cancersupportivecare.com]

Patel It most commonly presents as sensory neuropathy, including numbness, loss of proprioception sense, tingling, pins-and-needles sensation, hyperalgesia or allodynia in [healio.com]

Neuralgia

The key findings in neuropathic pain are: (a) pain in an area with sensory loss; (b) positive sensory symptoms such as dysesthaesia and allodynia in the injured area, where [doi.org]

Hyperalgesia, hyperesthesia or allodynia may also be associated20. [scielo.br]

It can cause burning, as well as allodynia, or hypersensitivity to non-painful stimuli. [cancertherapyadvisor.com]

Herpes Zoster

The typical clinical manifestation is an acute segmental eruption of herpetiform umbilicated vesicles associated with malaise, pain, dysaesthesia, allodynia and probably fever [ncbi.nlm.nih.gov]

Postherpetic neuralgia has the cardinal clinical features of all neuropathic pain syndromes, including sensory abnormalities, ongoing pain, and allodynia (touch-induced pain [doi.org]

Herpes Zoster Infection of the Chest Wall

We noted allodynia and hyperesthesia in these regions, and the left T5 dermatome revealed extreme sensitivity. [mdedge.com]

It is intensified by what would otherwise be nonpainful sensory stimulation, such as light touch (allodynia). [barnardhealth.us]

Although nerve entrapment would be expected to cause impingement and sometimes hypoesthesia, ZSH usually causes allodynia and hyperesthesia, as was the case in our patient [mdedge.com]

Erythromelalgia

The severe pain and allodynia indicated small-fiber neuropathy but muscle weakness suggested an involvement of large myelinated nerve fibers. [ncbi.nlm.nih.gov]

Allodynia was present. Figure 2: Right foot with minimal dorsal swelling and erythema over the toes. The foot was warm touch and allodynia was present. [omicsonline.org]

Mechanical allodynia and hyperpathia were present in his feet, ankles, and lower legs. [anesthesiology.pubs.asahq.org]

Intercostal Neuralgia

Allodynia is the abnormal perception of pain after a normally nonpainful mechanical or thermal stimulus [ 11 ]. [clinicalgate.com]

He did not have allodynia. [ci.nii.ac.jp]

Patients with allodynia may respond to light touch with an exaggerated pain response or report a sensation of heat when a cold stimulus is applied. [clinicalgate.com]

Diabetic Polyneuropathy

Most common form (typical): symmetric distal sensory or sensorimotor polyneuropathy Distressing numbness, tingling, pain of legs/feet, usually worse at night; allodynia; hyperalgesia [5minuteconsult.com]

Allodynia and hyperalgesia may be present. [pijn.com]

Upon further history taking and examination, it was noted to be because of mechanical allodynia (i.e. pain occurring on movement). [openaccessjournals.com]

Diabetic Pseudotabes

[…] pain Occurs in men with Type II diabetes that is poorly controlled Anorexia and weight loss is common Clinical presentation: Severe hyperalgesia, dynamic and static mechano allodynia [neurodiffdx.com]

[…] sensory neuropathy Diabetic Peripheral Neuropathy - 10 Severe painful neuropathy causes depression Diabetic neuropathic cachexias Severe exacerbations of burning pains, allodynia [slideserve.com]

[…] sensory neuropathy 12 Diabetic Peripheral Neuropathy - 10 Severe painful neuropathy causes depression Diabetic neuropathic cachexias Severe exacerbations of burning pains, allodynia [slideplayer.com]

Peripheral Neuropathy

Neurotoxicity was evaluated by the physician using the Oxaliplatin Sanofi Specific Scale and by the patient using the cold allodynia test and the Leonard scale. [ncbi.nlm.nih.gov]

You may experience: Numbness or tingling in the extremities Pricking sensations on the skin Muscle weakness Exaggerated or distorted sense of touch, called allodynia. [honorhealth.com]

Glossary of pain terms Term Meaning Allodynia Pain perceived following non-noxious, innocuous stimulus (eg light touch causes burning pain) Antalgia (antalgic) Pain perception [racgp.org.au]

Polyneuropathy

Neuropathic pain and allodynia is associated with hypersensitization of pain receptors in our skin resulting is the feeling of severe pain from stimuli that would normally [stemcellthailand.org]

[…] paresthesia sudden sharp pains burning or tingling sensations, especially in your feet and hands, known as distal polyneuropathy feeling extremely sensitive to touch, known as allodynia [healthline.com]

[…] proinflammatory (IL)-1β interleukin cytokine while increasing the anti-inflammatory (IL-10) cytokines in the lesioned nerve, along with significant reduction in mechanical allodynia [stemcellthailand.org]

Fibromyalgia

Pain is the predominant symptom and allodynia and hyperalgesia are common signs. [ncbi.nlm.nih.gov]

The only abnormalities observed occurred during the quantitative sensory test presenting as severe widespread allodynia to cold and hot temperatures and during Laser Evoked [ncbi.nlm.nih.gov]

Abstract Fibromyalgia is an idiopathic chronic condition that causes widespread musculoskeletal pain, hyperalgesia and allodynia. [ncbi.nlm.nih.gov]

Diabetic Mononeuropathy

Allodynia or pain to light touch. Weakness. Mononeuropathy also called Focal Neuropathy: This is typically seen more commonly in older adults. [apmhealth.com]

 Allodynia on sensory testing, a normal motor exam,reduced ankle reflexes. Poor glycemic control, may follow an episode of ketoacidosis Associated with weight losss & [slideshare.net]

Check and demarcate the area of allodynia, hyperalgesia, hypoalgesia, and numbness. Muscle wasting, tone, and Achilles reflexes. [academic.oup.com]

Chronic Pain

At the spots in the foot showing the most severe allodynia, bones were drilled with fluoroscopic assistance. [ncbi.nlm.nih.gov]

On clinical examination, he revealed a neuropathic pain, with prevalence of allodynia to touch, covering the entire anterior abdominal wall, from T7 to T12 dermatomes. [ncbi.nlm.nih.gov]

Examination and testing revealed static and dynamic mechanical allodynia along with neurological deficits on the left side of the face, implicating both peripheral and central [ncbi.nlm.nih.gov]

Progressive Multiple Sclerosis

Nervenheilkunde 2015; 34(11): 906-914 DOI: 10.1055/s-0038-1627641 Schattauer GmbH Gezielte Gruppengymnastik und progressives Gerätetraining Improvements on walking distance in patients with multiple sclerosis R. Alcantara 1 Gesundheitszentrum Westmünsterland GmbH, Ahaus, Borken, Legden, Vreden, L. Bernhardt 2[…] [thieme-connect.com]

Drug-Induced Headache

Terminating migraine with allodynia and ongoing central sensitization using parenteral administration of COX1/COX2 inhibitors. Headache. 2005;45(7):850–61. [ncbi.nlm.nih.gov]

Secondary Fibromyalgia

This can cause allodynia or hyperalgesia. In individuals with chronic pain, EEGs showed altered brain activity, suggesting pain-induced neuroplastic changes. [en.wikipedia.org]