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59 Possible Causes for Almond-Shaped Eyes, Downturned Corners of the Mouth

  • Prader-Willi Syndrome

    These include a narrow face, almond-shaped eyes, small-appearing mouth, a thin upper lip with downturned corners of the mouth, and full cheeks.[rarediseases.about.com] The clinical appearance of PWS includes dysmorphic facial features with almond-shaped eyes, a narrow bifrontal diameter, and a thin upper lip; short stature; central obesity[ncbi.nlm.nih.gov] Fig 1: Dysmorphic facial features: high prominent forehead, narrow bifrontal diameter, downturned corners of the mouth, micrognathia.[atlasgeneticsoncology.org]

  • Disorder of Sex Development - Intellectual Disability Syndrome

    Showing of 31 80%-99% of people have these symptoms Deeply set eye Deep set eye Deep-set eyes Sunken eye [ more ] 0000490 Downturned corners of mouth Downturned corners of[rarediseases.info.nih.gov] Children may be born with almond-shaped eyes, a narrowing of the head at the temples, a turned-down mouth and a thin upper lip. Poor sucking reflex.[mayoclinic.org] corners of mouth 60 33 hallmark (90%) Very frequent (99-80%) HP:0002714 16 hypoplasia of penis 60 33 hallmark (90%) Very frequent (99-80%) HP:0008736 17 spina bifida occulta[malacards.org]

  • Native American Myopathy

    corners of the mouth, short stature, and marked susceptibility to malignant hyperthermia.[ncbi.nlm.nih.gov] , bushy eyebrows XLD SLC9A6 #300243 CK SYNDROME Strabismus, epicanthal folds, upslanting palpebral fissures, almond-shaped eyes XLR NSDHL #300831 COCKAYNE SYNDROME Pigmentary[eyewiki.aao.org] Symptoms in NAM include congenital muscle weakness and contractures, progressive scoliosis, early ventilatory failure, a peculiar facial gestalt with mild ptosis and downturned[ncbi.nlm.nih.gov]

  • X-Linked Syndromic Intellectual Disability Type Nascimento

    corners of mouth Enophthalmos Low posterior hairline Macrocephaly Prominent supraorbital ridges Synophrys Thin vermilion border Upslanted palpebral fissure ... ...[familydiagnosis.com] […] type Nascimento (MIM #300860), caused by mutations in UBE2A (MIM *312180), is characterized by craniofacial dysmorphism (synophrys, prominent supraorbital ridges, deep-set, almond-shaped[ncbi.nlm.nih.gov] corners of mouth ; Dry skin ; Echolalia ; Hirsutism ; Hypointensity of cerebral white matter on MRI ; Increased body weight ; Intellectual disability ; Low posterior hairline[mousephenotype.org]

  • Frontonasal Dysplasia

    […] of the mouth.[ncbi.nlm.nih.gov] Ocular: narrowed eye slits, almond shaped eyes, epicanthal folds (extra eyelid tissue), epibulbar dermoids (benign tumors of the eye), upper eyelid colombas (full thickness[en.wikipedia.org] Facial features were remarkable by nasal deformity with creased ridge and depressed or absent tip, widely spaced eyes, almond-shaped palpebral fissures, and downturned corners[ncbi.nlm.nih.gov]

  • Char Syndrome

    corners of mouth Missing fingers or toes Congenital diaphragmatic hernia Other suggestive features: Developmental delay and/or intellectual disability Small prenatal and[en.wikipedia.org] […] patent ductus arteriosus, short philtrum, duck-bill lips, strabismus, a flat nasal bridge, a broad forehead, low-set ears, hypertelorism, up-slanting palpebral fissures, almond-shaped[ncbi.nlm.nih.gov] […] have CdLS. [1] Key features Long and/or thick eyebrows Short nose Concave nasal ridge and/or upturned nasal tip Long and/or smooth philtrum Thin upper lip vermilion and/or downturned[en.wikipedia.org]

  • Absent Thumb - Short Stature - Immunodeficiency Syndrome

    corners of the mouth, thin lips, abnormal frontal lobes [imagiological], minor congenital heart defects; no sacral defects, anorectal anomalies, or haloprosencephaly qter[chr7.org] Upon examination, he presented with short stature, neck webbing, and craniofacial dysmorphic features comprising full cheeks, prominent widened nasal bridge, almond-shaped[bmcmedgenet.biomedcentral.com] Congenital neurobehavioral disorder characterized by rounded face, low forehead, almond shaped eyes, squinting, hypogonadism, hypotonia, insatiable appetite leading to obesity[icd10data.com]

  • Wolf-Hirschhorn Syndrome

    Microcephaly, hypertelorism, prominent glabella, high arched eyebrows, broad nose, short philtrum, downturned corners of the mouth, dysplastic ears with pits/tags.[genetics4medics.com] 15p12 Mental retardation Early failure to thrive followed by compulsive eating disorder and obesity at about 2 yr Decreased muscle mass Small hands and feet Hypogonadism Almond-shaped[alpfmedical.info] corner of the mouth Microcephaly Low-set ears with pits or tags Intrauterine growth restriction (IUGR)/postnatal growth deficiency Hypotonia with decreased muscle bulk Present[emedicine.medscape.com]

  • SHORT Syndrome

    corners of the mouth, micrognathia and prominent (but not typically low-set or posteriorly located) ears.[orpha.net] Congenital neurobehavioral disorder characterized by rounded face, low forehead, almond shaped eyes, squinting, hypogonadism, hypotonia, insatiable appetite leading to obesity[icd10data.com] For example, many but not all people with Down syndrome have almond-shaped eyes and a short stature.[globaldownsyndrome.org]

  • Microdeletion 3q29 Syndrome

    […] of the eyes ( epicanthal folds ), and downturned corners of the mouth. 5p15.2pter deletion (Cri-du-chat syndrome) Developmental delays and intellectual disabilities are present[portal.bsc.gwu.edu] […] including: epicanthal folds, a broad nasal bridge with a prominent metopic suture and micrognathia, asymmetric face with the right face and lips drooping, and myopathic face, almond-shaped[ashg.org] […] size ( microcephaly ), a distinctly wide nasal bridge that continues into the forehead, wide spaced eyes, a small lower jaw ( micrognathia ), folds of skin over the inside corners[portal.bsc.gwu.edu]

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