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63 Possible Causes for Almond-Shaped Eyes, Neonatal Hypotonia

  • Prader-Willi Syndrome

    The clinical appearance of PWS includes dysmorphic facial features with almond-shaped eyes, a narrow bifrontal diameter, and a thin upper lip; short stature; central obesity[ncbi.nlm.nih.gov] Hyperphagia, intellectual disabilities/behavioral disorders, neonatal hypotonia, and hypogonadism are cardinal features for PWS.[ncbi.nlm.nih.gov] Different from western patients, the 20 Asian patients exhibited at least five of the following typical features: prominent forehead, narrow face, almond-shaped eyes, small[ncbi.nlm.nih.gov]

  • Down Syndrome

    Frequently the first feature noticed is hypotonia. Neonatal features of Down's syndrome General: Hyperflexibility. Muscular hypotonia.[patient.info] Some common physical features of Down syndrome include: A flattened face, especially the bridge of the nose Almond-shaped eyes that slant up A short neck Small ears A tongue[cdc.gov] Motor control and hypotonia Neonates with DS present with muscle hypotonia and many individuals with DS demonstrate some form of motor impairment, often described as clumsiness[doi.org]

  • Velocardiofacial Syndrome

    Although the range and severity of symptoms may vary, PMS is generally thought to be characterized by neonatal hypotonia (low muscle tone in the newborn), normal growth, absent[rarediseases.org] Typical facial features include a long face, small almond shaped eyes, a wide bridged nose, and malformations of the ear.[genedx.com] […] includes: cleft palate, usually of the soft palate (the roof of the mouth nearest the throat which is behind the bony palate); heart problems; similar faces (elongated face, almond-shaped[healthieryou.com]

  • Autosomal Recessive Lower Motor Neuron Disease with Childhood Onset

    SMA1 must be distinguished from other causes of neonatal hypotonia which include CNS malformations, metabolic diseases, infections, and congenital myopathies.[neuropathology-web.org] shaped eyes, obesity, and a constant desire for food, coordination impairments and mental retardation -Developmental abnormality due to insufficient closure of the neural[quizlet.com] Etiology is causative factor is partial deletion of chromosome 15 -Symptoms include physical and behavioral attributes such as small hands, feet and sex organs, hypotonia, almond[quizlet.com]

  • Isolated Congenital Sclerocornea

    hypotonia Joint laxity Conductive hearing impairment Pes planus Oxycephaly Osteoporosis Hernia Anterior segment developmental abnormality Need help with a diagnosis?[mendelian.co] , bushy eyebrows/XLD/SLC9A6/#300243 CK SYNDROME/Strabismus, epicanthal folds, upslanting palpebral fissures, almond-shaped eyes/XLR/NSDHL/#300831 COCKAYNE SYNDROME/Pigmentary[eyewiki.org] […] susceptibility Joint hypermobility Arachnodactyly Pulmonic stenosis Talipes Pectus carinatum Abnormality of the dentition Camptodactyly Abnormality of the eye Hyperlordosis Myalgia Neonatal[mendelian.co]

  • Neonatal Hypotonia

    Abstract The objectives of our study were to determine the actual frequency of the different disorders causing neonatal hypotonia and to assess the reliability of the first[ncbi.nlm.nih.gov] The face is often characterized by strabismus, almond-shaped eyes, triangular mouth and a narrow bifrontal diameter. Plethoric obesity is striking feature.[pediatriceducation.org] The eyes have been described as "almond-shaped". Strabismus and nystagmus are commonly present.[disorders.eyes.arizona.edu]

  • Blepharoptosis - Myopia - Ectopia Lentis Syndrome

    Intermediate uveitis Elevated proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells High forehead Neonatal hypotonia Bilateral ptosis Open mouth Broad-based[mendelian.co] , bushy eyebrows/XLD/SLC9A6/#300243 CK SYNDROME/Strabismus, epicanthal folds, upslanting palpebral fissures, almond-shaped eyes/XLR/NSDHL/#300831 COCKAYNE SYNDROME/Pigmentary[eyewiki.org] , bushy eyebrows XLD SLC9A6 #300243 CK SYNDROME Strabismus, epicanthal folds, upslanting palpebral fissures, almond-shaped eyes XLR NSDHL #300831 COCKAYNE SYNDROME Pigmentary[eyewiki.aao.org]

  • Microdeletion 3q29 Syndrome

    hypotonia-seizures-encephalopathy syndrome due to 5q31.3 microdeletion Smith-Magenis syndrome Sporadic fetal brain disruption sequence Temple syndrome due to paternal 14q32.2[se-atlas.de] […] including: epicanthal folds, a broad nasal bridge with a prominent metopic suture and micrognathia, asymmetric face with the right face and lips drooping, and myopathic face, almond-shaped[ashg.org] […] microdeletion syndrome Proximal 16p11.2 microdeletion syndrome Rare developmental defect during embryogenesis Rare pervasive developmental disorder Rett syndrome Severe neonatal[se-atlas.de]

  • Rett Syndrome

    Both showed neurological symptoms from the neonatal period, including hypotonia, irritability and severe microcephaly.[ncbi.nlm.nih.gov] They also have unique pixie-like facial features–almond shaped eyes, oval ears, full lips, small chins, narrow faces, and broad mouths.[autism.com]

  • ROHHAD Syndrome

    hypotonia, or decreased muscle tone, and the characteristic small hands and feet associated with the syndrome.[hopkinsmedicine.org] eyes [ 10 ].[ojrd.biomedcentral.com] Vasomotor tone (ice cold hands and feet) Yes No Main Features of PWS Decreased fetal movement No Yes Neonatal hypotonia No Yes Neonatal feeding problems No Yes Neonatal lethargy[ncbi.nlm.nih.gov]

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