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10 Possible Causes for Alopecia, Average Intelligence, Wide Space Between the First and Second Toe

  • Dubowitz Syndrome

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] […] dysostosis syndrome Skin fragility-woolly hair-palmoplantar keratoderma syndrome Osteopathia striata cranial sclerosis Brachycephalofrontonasal dysplasia Thumb deformity, alopecia[checkrare.com] Results indicate that the level of intellectual functioning among children with Dubowitz syndrome varies from severe retardation to average intelligence.[ncbi.nlm.nih.gov]

  • Seckel Syndrome

    Affected individuals displayed telangiectases, alopecia, and other malignancies such as nonmelanoma skin cancer, and less commonly breast cancer and cervical cancer.[preventiongenetics.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] […] is considered lower than average Can affect boys and girls equally Genetics of Seckel Syndrome Autosomal recessive pattern Additional reading about Seckel Syndrome National[littlepeopleuk.org]

  • Russell-Silver Syndrome

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Holoacardius amorphus Holt-Oram syndrome Homologous chimera Hyperhidrosis, premature cavities and premolar aplasia Hyperthermia-induced defect Hypogonadism, diabetes mellitus, alopecia[icd9data.com] Wide space between first and second toes Wide-spaced big toe Widely spaced 1st-2nd toes Widely spaced first and second toes Widened gap 1st-2nd toes Widened gap first and[rarediseases.info.nih.gov]

  • Down Syndrome

    A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org] Additional external findings included alopecia universalis, penoscrotal hypospadias, ostium secundum type of atrial septal defect, right ventricular cardiac dilatation, diffuse[ncbi.nlm.nih.gov] The intelligence quotient (IQ) among children with Down syndrome varies but averages about 50, compared with normal children, whose average IQ is 100.[merckmanuals.com]

  • Ring Chromosome 10

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] […] karyotypes unavailable (12) 5 years/F––Growth delay–PMDDWilms tumor46,XX,r(11)(p15.5q25)Present case report5 years/FPrecocious puberty, severe hirsutism amenorrhea, androgenic alopecia[edmcasereports.com] Prenatal diagnosis of a female carrier of a familial r(Jeny21) who was of above average intelligence with a normal phenotype; revealed a twin pregnancy with a 46,XX,r(21)[tp.amegroups.com]

  • Familial Congenital Nasolacrimal Duct Obstruction

    space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org] […] is often subnormal and, in one study of 15 patients with Apert syndrome, the average IQ was 72.5. 66 Development may be adversely affected by progression of increased intracranial[entokey.com] Patients may have frontal alopecia, cardiomyopathy and testicular atrophy.[reviewofophthalmology.com]

  • Genee-Wiedemann Syndrome

    […] universalis; 203655; HR Alopecia, neurologic defects, and endocrinopathy syndrome; 612079; RBM28 Alpers syndrome; 203700; POLG Alpha/beta T-cell lymphopenia with gamma/delta[howlingpixel.com] He had a wide space between the first and second toe of his feet and subungual fibroma on the second and third toe of the right foot and on the third toe of the left foot.[jmg.bmj.com] They typically have normal intelligence and normal lifespans.[chop.edu]

  • MORM Syndrome

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] , and Endocrinopathy Syndrome Alopecia-Mental Retardation Syndrome 1 Alopecia-Mental Retardation Syndrome 2 Alopecia-Mental Retardation Syndrome 3 Alopecia-Mental Retardation[rgd.mcw.edu] The average intelligence quotient (IQ) of adult males with the most severe mutation is 40, although those with less severe mutations can have IQs in the borderline to normal[spectrumnews.org]

  • Multiple Epiphyseal Dysplasia - Severe Proximal Femoral Dysplasia

    Ectodermal changes with alopecia and coarse hair, cataract, skin manifestations such as ichthyosis, hyperkeratosis, erythrodermia or desquamation are common and there may[boneandspine.com] (C) Adduction of the right forefoot with wide spacing between the first and second toes. The left foot shows only mild shortening of the first toe.[jmg.bmj.com] […] usually normal or above average Obesity is a problem Dental crowding and ear problems secondary to bone overgrowth X-Rays All long tubular bones are affected Metaphysis is[flinders.edu.au]

  • Macrocephaly-Developmental Delay Syndrome

    space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org] The intelligence quotient according to the Leiter scale equaled 75, which is below the average.[ispub.com] Eventually regress to form linear hypopigmented lesions - Alopecia - Hypodontia (teeth failure) - Dystrophic nails - Neuro (motor delay, seizures) - Bones (hemivertebrae,[quizlet.com]

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