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23 Possible Causes for Alopecia, Focal Keratoderma of Soles, Headache

  • Growth Hormone Deficiency

    Palmoplantar keratoderma (PPK) is a diverse group of disorders, characterized by thickening of the palms and soles, which are subdivided into focal or diffuse; it can be acquired[] CASE PRESENTATION: Here, we describe a 17-year old boy referred to our hospital for fatigue, decreased muscle strength and severe headache reported after the cessation of[] The non-inflammatory type usually will not be complicated by scarring alopecia.[]

  • Erythema Palmaris Hereditarium

    […] involving the whole of the palms and soles. [1] :506–8 [2] :213 Focal Focal palmoplantar keratoderma, a type of palmoplantar keratoderma in which large, compact masses of[] It is manifested by chills, fever, headache, myalgias, and exacerbation of cutaneous lesions. Duration is typically a few hours.[] Alopecia antibody deficiency Alopecia totalis Alopecia universalis Alopecia-contractures-dwarfism-intellectual disability syndrome Alopecia-epilepsy-pyorrhea-intellectual[]

  • Lamellar Ichthyosis

    […] and soles ( Lucker et al., 1994 ).For a discussion of phenotypic and genetic heterogeneity of palmoplantar keratoderma, see epidermolytic PPK ( OMIM ).[] ., plus frontal/temporal headache & lacrimal sweating herpes zoster of facial & auditory nerves, external ear with ipsilateral facial paralysis occasional deafness, tinnitus[] Generalized large, dark, platelike scale increased in flexures; erythroderma; ectropion; palmoplantar keratoderma; decreased sweating with heat intolerance Hair: Scarring alopecia[]

  • Palmoplantar Keratosis

    […] x-linked dominant condition that begins in early childhood with thick focal keratoderma over the soles and, to a lesser extent, the palms.[] Use cautiously with headache, hyperthyroidism (overactive thyroid), or if fair-skinned. Avoid if pregnant or breastfeeding.[] alopecia.[]

  • Pachyonychia Congenita

    Fig 2: Showing focal keratoderma on soles. Fig 3: Showing pachyonychia in hands and feet. Fig 4: Showing leukoplakia on tongue and angular cheilitis of mouth.[] Use cautiously with headache, hyperthyroidism (overactive thyroid), or if fair-skinned. Avoid if pregnant or breastfeeding.[] Differential diagnoses include alopecia areata, androgenetic alopecia and traction alopecia/ trichotillomania.[]

  • Epidermolysis Bullosa Simplex Type Cockayne-Touraine

    ., belt line) Generalized Generalized Generalized Grouped (herpetiform) No No Sometimes Yes Mucosal Rare Occasionally Occasionally Often Hyperkeratosis of palms & soles (keratoderma[] The syndrome may be accompanied by high fever, malaise, chills, headache, tachycardia, tachypnea, and prostration.[] Nail dystrophy, milia atrophic scarring and scarring alopecia are seen.[]

  • Ovarian Cyst

    Pachyonychia congenita Clinical features of pachyonychia congenita Palms and soles Thickened or calloused palms and soles ( palmoplantar hyperkeratosis or keratoderma, particularly[] A 12-year-old Caucasian female presented with headaches and fatigue. Imaging to evaluate her headaches revealed a pituitary macroadenoma.[] […] palmoplantar keratoderma; see these terms) and disorders manifesting with dystrophic nails such as epidermolysis bullosa, Clouston syndrome (distinguished by the presence of alopecia[]

  • Pityriasis Rubra Pilaris

    There was a waxy orange keratoderma affecting the palms and soles with associated painful fissuring ( figure 3 ).[] […] ustekinumab in the office every 12 weeks and she is monitored for side effects throughout, including but not limited to nasopharyngitis, upper respiratory tract infection, headache[] […] characterized first by a dry scaly rash involving her face, trunk, and extremities with hyperpigmentation and islands of spared skin and minimal erythroderma, followed by alopecia[]

  • Chest Wall Disorder

    Necrolytic migratory erythema due to glucagonoma Tylosis Tylosis is an autosomal dominant form of focal, non-frictional and nonepidermolytic, palmoplantar keratoderma.[] .-); back pain (M54.9); breast pain (N64.4); chest pain (R07.1-R07.9); ear pain (H92.0-); eye pain (H57.1); headache (R51); joint pain (M25.5-); limb pain (M79.6-); lumbar[] They also may sweat a lot during sleep and may have headaches in the morning. Bedwetting or sleep terrors also may occur.[]

  • Tricho-Oculo-Dermo-Vertebral Syndrome

    focal keratoderma over the soles.[] Headache, blurring or dimness of vision, and sometimes dizziness or nausea may also occur. Anatomic features of the eye.[] (PPK; alopecia congenita with keratosis palmoplantaris, OMIM 104100).[]

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