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32 Possible Causes for Alopecia, Focal Keratoderma of Soles, Hypothyroidism

  • Growth Hormone Deficiency

    Palmoplantar keratoderma (PPK) is a diverse group of disorders, characterized by thickening of the palms and soles, which are subdivided into focal or diffuse; it can be acquired[ncbi.nlm.nih.gov] A positive thyroid autoantibody titer confirmed the diagnosis of chronic lymphocytic thyroiditis with hypothyroidism.[ncbi.nlm.nih.gov] The non-inflammatory type usually will not be complicated by scarring alopecia.[ncbi.nlm.nih.gov]

  • Lamellar Ichthyosis

    […] and soles ( Lucker et al., 1994 ).For a discussion of phenotypic and genetic heterogeneity of palmoplantar keratoderma, see epidermolytic PPK ( OMIM ).[mendelian.co] We present the first case of an infant, born to consanguineous parents, with congenital lamellar ichthyosis, congenital lymphatic malformation, congenital hypothyroidism,[ncbi.nlm.nih.gov] Generalized large, dark, platelike scale increased in flexures; erythroderma; ectropion; palmoplantar keratoderma; decreased sweating with heat intolerance Hair: Scarring alopecia[cram.com]

  • Diffuse Palmoplantar Keratoderma

    […] involving the whole of the palms and soles. [1] : 506-8 [2] : 213 Focal Focal palmoplantar keratoderma, a type of palmoplantar keratoderma in which large, compact masses[like2do.com] […] etodolac, mepacrine, proguanil, mexiletine, methyldopa, lithium, venlafaxine, gold, fluorouracil, bleomycin, hydroxyurea, practolol and doxorubicin. 5 Systemic diseases like myxedema[jemds.com] The hair is sparse and pale, and the alopecia can be patchy or total. Hair loss may lead to total alopecia by puberty.[ncbi.nlm.nih.gov]

  • Pachyonychia Congenita Type 1

    Fig 2: Showing focal keratoderma on soles. Fig 3: Showing pachyonychia in hands and feet. Fig 4: Showing leukoplakia on tongue and angular cheilitis of mouth.[edoj.org.eg] Nail dysplasia Hypoplasia of the thymus Severe combined immunodeficiency Thyroiditis Ventricular septal defect Autosomal dominant inheritance Hyperhidrosis Absent eyebrow Hypothyroidism[mendelian.co] Authors, Source MeSH Adult Alopecia Blister Bone Diseases Cataract Child, Preschool Cornea Darier Disease Eye Diseases Female Humans Intellectual Disability Keratosis Leukoplakia[unboundmedicine.com]

  • Erythema Palmaris Hereditarium

    […] involving the whole of the palms and soles. [1] :506–8 [2] :213 Focal Focal palmoplantar keratoderma, a type of palmoplantar keratoderma in which large, compact masses of[ipfs.io] Alopecia antibody deficiency Alopecia totalis Alopecia universalis Alopecia-contractures-dwarfism-intellectual disability syndrome Alopecia-epilepsy-pyorrhea-intellectual[se-atlas.de] Hyperthyroidism causes pretibial myxedema (thickened waxy plaques occurring in up to 10% of patients and almost always with accompanying ophthalmopathy), palmar erythema,[medical-dictionary.thefreedictionary.com]

  • Epidermolysis Bullosa

    ., belt line) Generalized Generalized Generalized Grouped (herpetiform) No No Sometimes Yes Mucosal Rare Occasionally Occasionally Often Hyperkeratosis of palms & soles (keratoderma[ncbi.nlm.nih.gov] The endocrinology department ruled out associated hypothyroidism and suprarenal insufficiency.[revistanefrologia.com] Other characteristic features of this condition include alopecia, malformed fingernails and toenails, and irregular tooth enamel.[ghr.nlm.nih.gov]

  • Palmoplantar Keratosis

    […] x-linked dominant condition that begins in early childhood with thick focal keratoderma over the soles and, to a lesser extent, the palms.[en.wikipedia.org] Hodak E, David M, Feuerman EJ.: Palmoplantar keratoderma in association with myxedema. Acta Derm Venerol 1986; 66: 354–7 PubMed Google Scholar 46.[doi.org] alopecia.[diseaseinfosearch.org]

  • Ovarian Cyst

    Pachyonychia congenita Clinical features of pachyonychia congenita Palms and soles Thickened or calloused palms and soles ( palmoplantar hyperkeratosis or keratoderma, particularly[dermnetnz.org] […] palmoplantar keratoderma; see these terms) and disorders manifesting with dystrophic nails such as epidermolysis bullosa, Clouston syndrome (distinguished by the presence of alopecia[orpha.net] Laboratory studies showed severe hypothyroidism, mild anemia, hyperlipidemia, hyperprolactinemia and an elevated level of cancer antigen-125.[ncbi.nlm.nih.gov]

  • Pityriasis Rubra Pilaris

    There was a waxy orange keratoderma affecting the palms and soles with associated painful fissuring ( figure 3 ).[casereports.bmj.com] Key words: Hypothyroidism; Pityriasis rubra pilaris; Therapeutics INTRODUCTION Pityriasis Rubra Pilaris is a chronic dermatosis of unknown etiology.[scielo.br] […] characterized first by a dry scaly rash involving her face, trunk, and extremities with hyperpigmentation and islands of spared skin and minimal erythroderma, followed by alopecia[ncbi.nlm.nih.gov]

  • Epidermolysis Bullosa Simplex Type Cockayne-Touraine

    ., belt line) Generalized Generalized Generalized Grouped (herpetiform) No No Sometimes Yes Mucosal Rare Occasionally Occasionally Often Hyperkeratosis of palms & soles (keratoderma[ncbi.nlm.nih.gov] Ectodermal dysplasia blindness Ectodermal dysplasia ectrodactyly macular dystrophy Ectodermal dysplasia hypohidrotic autosomal dominant Ectodermal dysplasia hypohidrotic hypothyroidism[bioreference.net] Nail dystrophy, milia atrophic scarring and scarring alopecia are seen.[kissesforkatie.org]

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