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25 Possible Causes for Alopecia, Focal Keratoderma of Soles, Microcephaly

  • Growth Hormone Deficiency

    Palmoplantar keratoderma (PPK) is a diverse group of disorders, characterized by thickening of the palms and soles, which are subdivided into focal or diffuse; it can be acquired[ncbi.nlm.nih.gov] […] characterization of the clinical and molecular basis of a novel autosomal-recessive syndrome manifesting severe mental retardation, ataxia, speech impairment, epilepsy, short stature, microcephaly[ncbi.nlm.nih.gov] The non-inflammatory type usually will not be complicated by scarring alopecia.[ncbi.nlm.nih.gov]

  • Diffuse Palmoplantar Keratoderma

    […] involving the whole of the palms and soles. [1] : 506-8 [2] : 213 Focal Focal palmoplantar keratoderma, a type of palmoplantar keratoderma in which large, compact masses[like2do.com] The hair is sparse and pale, and the alopecia can be patchy or total. Hair loss may lead to total alopecia by puberty.[ncbi.nlm.nih.gov] […] pressure areas of palms and soles Birth No No H, F H Naxos Disease EKG Cardiologist CEDNIK syndrome Cerebral dygenesis, neuropathy, ichthyosis and keratoderma 757.4 SNAP29 Microcephaly[dermatologyadvisor.com]

  • Pachyonychia Congenita Type 1

    Fig 2: Showing focal keratoderma on soles. Fig 3: Showing pachyonychia in hands and feet. Fig 4: Showing leukoplakia on tongue and angular cheilitis of mouth.[edoj.org.eg] Authors, Source MeSH Adult Alopecia Blister Bone Diseases Cataract Child, Preschool Cornea Darier Disease Eye Diseases Female Humans Intellectual Disability Keratosis Leukoplakia[unboundmedicine.com] […] muscular dystrophy autosomal dominant macrothrombocytopenia TUBB1-related autosomal dominant mental retardation 55 autosomal dominant mental retardation 56 autosomal dominant microcephaly[rgd.mcw.edu]

  • Erythema Palmaris Hereditarium

    […] involving the whole of the palms and soles. [1] :506–8 [2] :213 Focal Focal palmoplantar keratoderma, a type of palmoplantar keratoderma in which large, compact masses of[ipfs.io] XERODERMA PIGMENTOSUM Is also known as xeroderma pigmentosum i xp1 xp, group a xp Related symptoms: Intellectual disability Seizures Short stature Hearing impairment Microcephaly[mendelian.co] Alopecia antibody deficiency Alopecia totalis Alopecia universalis Alopecia-contractures-dwarfism-intellectual disability syndrome Alopecia-epilepsy-pyorrhea-intellectual[se-atlas.de]

  • Lamellar Ichthyosis

    […] and soles ( Lucker et al., 1994 ).For a discussion of phenotypic and genetic heterogeneity of palmoplantar keratoderma, see epidermolytic PPK ( OMIM ).[mendelian.co] Crouzon's d. calcinosis cutis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, telangiectasia partial 5p deletion; hypertelorism, microcephaly, MR, high-pitch[readbag.com] Generalized large, dark, platelike scale increased in flexures; erythroderma; ectropion; palmoplantar keratoderma; decreased sweating with heat intolerance Hair: Scarring alopecia[cram.com]

  • Epidermolysis Bullosa Simplex Type Cockayne-Touraine

    ., belt line) Generalized Generalized Generalized Grouped (herpetiform) No No Sometimes Yes Mucosal Rare Occasionally Occasionally Often Hyperkeratosis of palms & soles (keratoderma[ncbi.nlm.nih.gov] Epididymitis Epilepsy benign neonatal dominant form Epilepsy benign neonatal recessive form Epilepsy juvenile absence Epilepsy mental deterioration Finnish type Epilepsy microcephaly[bioreference.net] Nail dystrophy, milia atrophic scarring and scarring alopecia are seen.[kissesforkatie.org]

  • Palmoplantar Keratosis

    […] x-linked dominant condition that begins in early childhood with thick focal keratoderma over the soles and, to a lesser extent, the palms.[en.wikipedia.org] […] impairment Cutaneous photosensitivity Glaucoma Infantile onset Hyperhidrosis Ichthyosis Fragile nails Diffuse palmoplantar keratoderma Mandibular prognathia Short stature Microcephaly[mendelian.co] alopecia.[diseaseinfosearch.org]

  • Pachyonychia Congenita

    Fig 2: Showing focal keratoderma on soles. Fig 3: Showing pachyonychia in hands and feet. Fig 4: Showing leukoplakia on tongue and angular cheilitis of mouth.[edoj.org.eg] Differential diagnoses include alopecia areata, androgenetic alopecia and traction alopecia/ trichotillomania.[ncbi.nlm.nih.gov] We report an infant who had clinical features consistent with pachyonychia congenita type II, with unusual features of microcephaly, seizures, electroencephalogram abnormalities[ncbi.nlm.nih.gov]

  • Palmoplantar Keratoderma-Spastic Paralysis Syndrome

    […] and nail dystrophy" [ 1 ] ) is an autosomal dominant or x-linked dominant condition that begins in early childhood with thick focal keratoderma over the soles and, to a lesser[en.academic.ru] IV; ML4 Is also known as ml iv, sialolipidosis; Related symptoms: Autosomal recessive inheritance Intellectual disability Global developmental delay Generalized hypotonia Microcephaly[mendelian.co] Alopecia congenita keratosis palmoplantaris 0 *Alopecia/congenital *Keratoderma, Palmoplantar.[reference.md]

  • Ectodermal Dysplasia-Sensorineural Deafness Syndrome

    Focal keratodermas mainly affect pressure areas. Punctate-type keratodermas result in tiny bumps on the palms and soles.[dermnetnz.org] Microcephaly deafness syndrome 0 *Facies *Deafness *Intellectual Disability *Microcephaly Ear/abnormalities.[reference.md] Ectodermal dysplasia with alopecia, onychodysplasia, hypohidrosis, keratoderma, abnormal teeth and deafness.[ijdvl.com]

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