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41 Possible Causes for Alopecia, Focal Keratoderma of Soles, Nail Abnormality

  • Pachyonychia Congenita Type 1

    Fig 2: Showing focal keratoderma on soles. Fig 3: Showing pachyonychia in hands and feet. Fig 4: Showing leukoplakia on tongue and angular cheilitis of mouth.[edoj.org.eg] Authors, Source MeSH Adult Alopecia Blister Bone Diseases Cataract Child, Preschool Cornea Darier Disease Eye Diseases Female Humans Intellectual Disability Keratosis Leukoplakia[unboundmedicine.com] No nail abnormalities were observed even one year after stopping treatment. Two major subtypes of pachyonychia congenita are recognized.[ijdvl.com]

  • Epidermolysis Bullosa

    ., belt line) Generalized Generalized Generalized Grouped (herpetiform) No No Sometimes Yes Mucosal Rare Occasionally Occasionally Often Hyperkeratosis of palms & soles (keratoderma[ncbi.nlm.nih.gov] In less severe forms of junctional EB, skin fragility is accompanied by dental enamel defects, nail abnormality and loss, and sometimes sparse hair. What are the causes?[cafamily.org.uk] Other characteristic features of this condition include alopecia, malformed fingernails and toenails, and irregular tooth enamel.[ghr.nlm.nih.gov]

  • Lamellar Ichthyosis

    […] and soles ( Lucker et al., 1994 ).For a discussion of phenotypic and genetic heterogeneity of palmoplantar keratoderma, see epidermolytic PPK ( OMIM ).[mendelian.co] We present the case of a young woman with the following features: lamellar ichthyosis, dwarfism, mental retardation, nail and dental abnormalities, unusual facies, poor sexual[ncbi.nlm.nih.gov] Generalized large, dark, platelike scale increased in flexures; erythroderma; ectropion; palmoplantar keratoderma; decreased sweating with heat intolerance Hair: Scarring alopecia[cram.com]

  • Pachyonychia Congenita

    Fig 2: Showing focal keratoderma on soles. Fig 3: Showing pachyonychia in hands and feet. Fig 4: Showing leukoplakia on tongue and angular cheilitis of mouth.[edoj.org.eg] Differential diagnoses include alopecia areata, androgenetic alopecia and traction alopecia/ trichotillomania.[ncbi.nlm.nih.gov] Pachyonychia congenita type I is an autosomal dominant disorder where nail abnormalities are a constant feature and develop during childhood.[ncbi.nlm.nih.gov]

  • Palmoplantar Keratosis

    […] x-linked dominant condition that begins in early childhood with thick focal keratoderma over the soles and, to a lesser extent, the palms.[en.wikipedia.org] Other clinical features are sclerodactyly and nail abnormalities (hypoplasia, fissuring, ridging, koilonychia).[intechopen.com] alopecia.[diseaseinfosearch.org]

  • Diffuse Palmoplantar Keratoderma

    […] involving the whole of the palms and soles. [1] : 506-8 [2] : 213 Focal Focal palmoplantar keratoderma, a type of palmoplantar keratoderma in which large, compact masses[like2do.com] The hair is sparse and pale, and the alopecia can be patchy or total. Hair loss may lead to total alopecia by puberty.[ncbi.nlm.nih.gov] Other clinical features include sclerodactyly and nail abnormalities (hypoplasia, fissuring, ridging, koilonychia).[emedicine.medscape.com]

  • Erythema Palmaris Hereditarium

    […] involving the whole of the palms and soles. [1] :506–8 [2] :213 Focal Focal palmoplantar keratoderma, a type of palmoplantar keratoderma in which large, compact masses of[ipfs.io] abnormalities such as longitudinal fissures, onychogryphosis, and onychomadesis are frequently reported. 4,10 The course of the disease is long-term, and spontaneous resolution[mdedge.com] Alopecia antibody deficiency Alopecia totalis Alopecia universalis Alopecia-contractures-dwarfism-intellectual disability syndrome Alopecia-epilepsy-pyorrhea-intellectual[se-atlas.de]

  • Autosomal Recessive Epidermolysis Bullosa Simplex

    ., belt line) Generalized Generalized Generalized Grouped (herpetiform) No No Sometimes Yes Mucosal Rare Occasionally Occasionally Often Hyperkeratosis of palms & soles (keratoderma[ncbi.nlm.nih.gov] Affected individuals also experience abnormal nail growth and hyperkeratosis of the palms and soles.[ghr.nlm.nih.gov] The patient subsequently developed cutaneous atrophy, nail dystrophy, milia and alopecia.[ncbi.nlm.nih.gov]

  • Papillon Lefevre Disease

    Focal keratodermas mainly affect pressure areas. Punctate-type keratodermas result in tiny bumps on the palms and soles.[dermnetnz.org] abnormalities PROGNOSIS Individuals with the disorder lose their primary teeth by age 5 and lose their permanent teeth during adolescence.[evolvegene.com] […] areata - Not a rare disease Alopecia totalis Alopecia universalis Amyloidosis AA Amyloidosis familial visceral Ataxia telangiectasia Autoimmune lymphoproliferative syndrome[rarediseases.info.nih.gov]

  • Punctate Palmoplantar Keratoderma Type 1

    […] involving the whole of the palms and soles. [1] : 506–8 [2] : 213 Focal [ edit ] Focal palmoplantar keratoderma, a type of palmoplantar keratoderma in which large, compact[en.wikipedia.org] abnormalities such as longitudinal fissures, onychogryphosis, and onychomadesis are frequently reported. 4,10 The course of the disease is long-term, and spontaneous resolution[mdedge.com] Alopecia, deafness, nail dystrophy, and dental loss may be associated.[emedicine.medscape.com]

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