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48 Possible Causes for Alopecia, Hypertrichosis of Eyebrows, Single Transverse Palmar Crease

  • Coffin-Siris Syndrome
  • Coffin-Lowry Syndrome

    transverse palmar crease 0000954 Sporadic No previous family history 0003745 Telecanthus Corners of eye widely separated 0000506 Thick eyebrow Bushy eyebrows Dense eyebrow[rarediseases.info.nih.gov] Holoacardius amorphus Holt-Oram syndrome Homologous chimera Hyperhidrosis, premature cavities and premolar aplasia Hyperthermia-induced defect Hypogonadism, diabetes mellitus, alopecia[icd9data.com] Large lower jaw Prominent chin Prominent lower jaw [ more ] 0000303 Mitral regurgitation 0001653 Prominent supraorbital ridges Prominent brow 0000336 Rectal prolapse 0002035 Single[rarediseases.info.nih.gov]

  • Rubinstein-Taybi Syndrome

    transverse palmar crease 0000954 Spina bifida occulta 0003298 Sporadic No previous family history 0003745 Stereotypy Repetitive movements Repetitive or self-injurious behavior[rarediseases.info.nih.gov] Holoacardius amorphus Holt-Oram syndrome Homologous chimera Hyperhidrosis, premature cavities and premolar aplasia Hyperthermia-induced defect Hypogonadism, diabetes mellitus, alopecia[icd9data.com] The common abnormalities include hypertrichosis and hirsuitism,heavy eyebrows, prominent beaked nose,hypoplastic maxilla, lowest ears and skeletal anomalies including broad[ispub.com]

  • Opitz-Kaveggia Syndrome

    Single transverse palmar creases and short hands and fingers have been less commonly observed in affected individuals [ Risheg et al 2007 ].[ncbi.nlm.nih.gov] […] hamartoma syndrome, autism, focal cortical dysplasia 20301661 RAB39B X-linked intellectual disability and macrocephaly with autism 20159109 RIN2 MACS syndrome (macrocephaly, alopecia[web.labmed.washington.edu] […] fullness, a wide mouth with full lips, and coarse facial features as well as fifth fingernail hypoplasia, absence of terminal phalanges, hypertrichosis, developmental delay[karger.com]

  • Lamellar Ichthyosis

    transverse palmar creases Abnormality of the fingernails Eczema Reduced bone mineral density Systemic lupus erythematosus Osteomyelitis Psoriasiform dermatitis Abnormality[mendelian.co] Generalized large, dark, platelike scale increased in flexures; erythroderma; ectropion; palmoplantar keratoderma; decreased sweating with heat intolerance Hair: Scarring alopecia[cram.com] , low nasal bridge, hypertrichosis late onset decreased immunoglobulins IgA, IgG, IgM; autoimmune diseases, alopecia areata, chronic giardiasis, eczema, recurrent otitis media[readbag.com]

  • Hypertrichotic Osteochondrodysplasia

    transverse palmar crease Tics Hernia Polyhydramnios Autosomal recessive inheritance Inguinal hernia Protruding ear Thin vermilion border High, narrow palate Delayed eruption[mendelian.co] - photophobia syndrome 40 Cases 79503 Ichthyosis hystrix of Curth- Macklin 6 Families 88621 Ichthyosis prematurity syndrome 16 Families 2269 Ichthyosis-alopecia-eclabion-[azkurs.org] Clinical description Dysmorphic features include macrocephaly and a coarse facial appearance with thick eyebrows, prominent supraorbital ridges, broad nasal bridge, anteverted[orpha.net]

  • Rapp-Hodgkin Syndrome

    transverse palmar creases Wide intermamillary distance Highly arched eyebrow Synophrys Neurological speech impairment Macrotia Abnormality of dental morphology Midface retrusion[mendelian.co] The ectodermal dysplasia manifests through uncombable, sparse, wiry hair; alopecia in adulthood; hypodontia; hypohidrosis; and dysplastic nails.[ncbi.nlm.nih.gov] The main features include dry, brittle hair with alopecia in adulthood, dental anomalies (hypodontia, microdontia with delayed eruption, fissured tongue, and retruded maxilla[ncbi.nlm.nih.gov]

  • Zlotogora-Ogur Syndrome

    transverse palmar creases Carious teeth Downslanted palpebral fissures Dystrophic fingernails Dystrophic toenail Highly arched eyebrow Hypogonadism Hypoplasia of the zygomatic[dovemed.com] […] of toes Frequent - Abnormal dentition / dental position / implantation / unerupted / dental ankylosis - Abnormally placed nipples - Absent / decreased / thin eyebrows - Alopecia[csbg.cnb.csic.es] Hypoplasia of the zygomatic bone Generalized hypertrichosis Breast aplasia Meningoencephalocele Abnormality of the genital system Bulbous nose Microtia Abnormality of the[mendelian.co]

  • SHORT Syndrome

    transverse palmar creases ( 60% of patients) Joint hyperextensibility or hyperflexibility Neuromuscular hypotonia Diastasis recti Dry skin Premature aging Congenital heart[emedicine.medscape.com] We and others noticed that some patients had features reminiscent of CdLS, particularly where facial hypertrichosis and prominent eyebrows were present.[nature.com] […] syndrome may include the following: Shortened extremities Short, broad hands, with short fifth finger with hypoplasia of the middle phalanx and clinodactyly, along with single[emedicine.medscape.com]

  • Bangstad Syndrome

    transverse palmar crease Small for gestational age Hypogonadism Osteoporosis Clinodactyly of the 5th finger Cerebellar agenesis Delayed skeletal maturation Abnormality of[mendelian.co] Particularly disheartening in this illness may be the occurrence of alopecia.[omicsonline.org] Alopecia is strongly positively associated with DRB1*04 and DRB1*0302. DRB1*04 is also more bound with alopecia totalis and universalis.[labs.pathology.jhu.edu]

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