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27 Possible Causes for Alpha Interferon Activity Increased

  • Chronic Fatigue Syndrome

    , increased interferon activity, cytokine levels, lymphocyte cell markers, or natural killer cells.[aafp.org] […] such as disabling lethargy, myalgias, and cognitive impairment, are similar to the effects observed with high dosage treatments of cytokines including interleukin-2 and alpha[aafp.org] interferon. 12, 13 Given that CFS may be an illness of immune dysregulation, numerous studies 14 – 18 have attempted to identify abnormalities in circulating immune complexes[aafp.org]

  • Lentigo Maligna Melanoma

    TLR7 activates the T-helper 1 response and increases the production of pro-inflammatory cytokines such as interferon alpha, tumor necrosis factor alpha, and interleukin (IL[synapse.koreamed.org]

  • Renal Cell Carcinoma

    Beta-D-glucans may promote dendritic cell (DC) maturation; increase interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha) and immunoglobulin levels; and may[cancer.gov] […] enhance natural killer (NK) cell activity, potentially boosting anti-tumor host immune responses.[cancer.gov] […] extract A dietary supplement containing an extract of the Basidiomycete fungus Agaricus blazei Murill with potential chemopreventive, antineoplastic and immunopotentiating activities[cancer.gov]

  • Lupus Erythematosus

    The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com] Reports pointing to important roles of interferon-alpha, transcription factors, and signaling variations also point to a central role for neutrophils. [21] Genetics There[emedicine.medscape.com]

  • Myocarditis

    The possible modes of action include enhancing natural killer cell activity, inducing production of alpha‐ and gamma‐interferon, improving cardiac microcirculation, and activity[doi.org] There are an increasing number of reports in the medical literature about liver toxicity, renal damage, and even cancer from some Chinese herbal products ( Ishizaki 1996 ;[doi.org]

  • Systemic Lupus Erythematosus

    The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.com] Reports pointing to important roles of interferon-alpha, transcription factors, and signaling variations also point to a central role for neutrophils. [21] Genetics There[emedicine.com]

  • Alcoholic Hepatitis

    We analyzed clinical, biological, virological and histological features in two cases where alpha-interferon treatment for HCV-related hepatitis led to a marked increase in[ncbi.nlm.nih.gov] […] aminotransferase activities. alpha-interferon as treatment of HCV-related hepatitis seemed to exacerbate acute alcoholic hepatitis despite moderate alcohol consumption.[ncbi.nlm.nih.gov]

  • Drug-induced Lupus Erythematosus

    The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com] Reports pointing to important roles of interferon-alpha, transcription factors, and signaling variations also point to a central role for neutrophils. [21] Genetics There[emedicine.medscape.com]

  • Chronic Active Hepatitis B

    CONCLUSIONS: alpha-interferon therapy for patients with chronic active hepatitis B is cost effective. alpha-Interferon is more cost effective in toddlers than adults because[ncbi.nlm.nih.gov] […] of the smaller dose required and the greater increase in life expectancy of children.[ncbi.nlm.nih.gov]

  • Keloid

    ; and increase collagenase activity.[emedicine.medscape.com] Numerous studies have demonstrated that these interferons reduce fibroblast synthesis of collagen types I, III, and, possibly, VI; reduce mucinous ground substance production[emedicine.medscape.com] […] multiple studies, have recurrence rates upward of 90%. [15, 24, 25, 26, 27] Interferon therapy One of the newest therapeutic modalities is intralesional injection of INF-alpha[emedicine.medscape.com]

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