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36 Possible Causes for Alpha Interferon Activity Increased, Anemia

  • Renal Cell Carcinoma

    Most common adverse events were fatigue (81%), stomatitis (60%), thrombocytopenia (56%), anemia (55%) and hand-foot syndrome (48%).[intjcancermanag.com] Beta-D-glucans may promote dendritic cell (DC) maturation; increase interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha) and immunoglobulin levels; and may[cancer.gov] Of several adverse events, only anemia and fatigue were significantly more frequently observed in older than younger patients.[ncbi.nlm.nih.gov]

  • Systemic Lupus Erythematosus

    Anemia is a common finding in children with systemic lupus erythematosus (SLE).[ncbi.nlm.nih.gov] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.com] She was diagnosed with SLE with pernicious anemia and iron deficiency anemia. The rare association of SLE with pernicious anemia was reported previously in few patients.[ncbi.nlm.nih.gov]

  • Infectious Mononucleosis

    An 18-year-old woman with infectious mononucleosis developed splenic infarction and severe anemia.[ncbi.nlm.nih.gov] Th1 lineage mostly produce type 2 interleukin (IL-2), interferon-gamma (INF-γ) and tumor necrosis factor-alpha (TNF-α).[omicsonline.org] Infectious mononucleosis (IM) is a rare cause of aplastic anemia in adults.[ncbi.nlm.nih.gov]

  • Alcoholic Hepatitis

    These include blood tests to determine presence of anemia, liver function tests, CT scan and MRI of the liver and liver biopsy.[symptoma.com] We analyzed clinical, biological, virological and histological features in two cases where alpha-interferon treatment for HCV-related hepatitis led to a marked increase in[ncbi.nlm.nih.gov] Signs and Tests: A CBC may show anemia and other abnormalities. Liver function tests such as ALP are abnormal. Liver biopsy shows alcoholic liver disease.[ihv.org]

  • Mycobacterium Avium Complex

    M. vium -complex infections are a common late consequence of HIV infection, particularly in persons with low CD4 cell counts and anemia.[atsjournals.org] Individuals with localized pulmonary MAC infections showed increased activation of monocytes and enhanced monocyte and T-cell tumor necrosis factor alpha (TNF-alpha) production[ncbi.nlm.nih.gov] A proportional hazards analysis of survival showed that M. avium-complex infection, severe anemia, zidovudine dose interruption, occurrence of an opportunistic infection,[ncbi.nlm.nih.gov]

  • Lupus Erythematosus

    IgA, IgG, or IgM) The positive test result for anti–2-glycoprotein I (IgA, IgG, or IgM) Low complement (C3, C4, or CH50) Direct Coombs’ test (in the absence of hemolytic anemia[rheumtutor.com] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com] […] women and is typically characterized by fever, skin rash, fatigue, and joint pain and often by disorders of the blood, kidneys, heart, lungs, and brain (such as hemolytic anemia[merriam-webster.com]

  • Waters-West Syndrome

    MalaCards based summary : Hemolytic Anemia, Lethal Congenital Nonspherocytic, with Genital and Other Abnormalities, is also known as hemolytic anemia lethal congenital nonspherocytic[malacards.org] Laboratory evaluation shows increased alpha-interferon ( IFNA1 ) activity with upregulation of interferon signaling and interferon-stimulated gene expression.[mendelian.co] Homepage Rare diseases Search Search for a rare disease Lethal hemolytic anemia-genital anomalies syndrome Disease definition Waters-West syndrome is characterized by the[orpha.net]

  • Zinc Deficiency

    BACKGROUND: Zinc deficiency is thought to be common in children, but its predictive capacity for anemia is unclear.[ncbi.nlm.nih.gov] Zinc increases the activity of the human cytokine interferon alpha responsible for preventing viral replication.[thetruthaboutcancer.com] Infantile tremor syndrome is characterized by coarse tremors, mental and physical retardation, light colored brown hair, skin pigmentation and anemia.[ncbi.nlm.nih.gov]

  • Drug-Induced Lupus Erythematosus

    […] assoc w SLE Hemolytic anemia associated with systemic lupus erythematosus Hemolytic anemia with Systemic lupus erythematosus Inflammatory myopathy due to lupus Inflammatory[icd9data.com] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com] Possible Complications Infection Thrombocytopenia purpura -- bleeding near the skin surface, resulting from a low number of platelets in the blood Hemolytic anemia Myocarditis[lutheranhealthcare.org]

  • Familial Hemophagocytic Lymphohistiocytosis

    This case report highlights the difficulty in managing posttransplant autoimmune hemolytic anemia.[ncbi.nlm.nih.gov] […] expression of tumor necrosis factor-alpha and interferon-gamma, leading to increased macrophage activation.[healio.com] Other significant findings include hepatosplenomegaly, progressive anemia, leukopenia, thrombocytopenia, hyperlipidemia and hypofibrinogenemia.[ncbi.nlm.nih.gov]

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