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19 Possible Causes for Alpha Interferon Activity Increased, Central Nervous System Disorder

  • Chronic Fatigue Syndrome

    , increased interferon activity, cytokine levels, lymphocyte cell markers, or natural killer cells.[aafp.org] Your doctor may perform the following imaging studies: CT scans or an MRI of the brain is useful to rule out other disorders of the central nervous system (CNS).[emedicinehealth.com] Despite autonomic dysfunction being accepted as evidence that CFS is a disorder of the central nervous system ( Nijs and Ickmans, 2013 ), imaging studies of the neural correlates[ncbi.nlm.nih.gov]

  • Infectious Mononucleosis

    Th1 lineage mostly produce type 2 interleukin (IL-2), interferon-gamma (INF-γ) and tumor necrosis factor-alpha (TNF-α).[omicsonline.org] In EBV infection levels of abnormal circulating Th1 lymphocytes are increased, leading to activation of cell-mediated immunity.[omicsonline.org]

  • Systemic Lupus Erythematosus

    The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.com] Abstract Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disorder that can involve any organ system.[ncbi.nlm.nih.gov] The signs and symptoms of SLE vary among affected individuals, and can involve many organs and systems, including the skin, joints, kidneys, lungs, central nervous system,[ghr.nlm.nih.gov]

  • Zinc Deficiency

    Zinc increases the activity of the human cytokine interferon alpha responsible for preventing viral replication.[thetruthaboutcancer.com] Journal of Central Nervous System Disease, 2 , 9-14 . [12] Üçkardeş et al. (2009).[blog.zrtlab.com] nervous system.[growyouthful.com]

  • HIV Infection

    […] are not generally increased, although expression of IL-1, IL-2, IL-6, IL-12, and interferon-gamma may be elevated.(112) With administration of antiretroviral therapies, these[hivinsite.ucsf.edu] Acute disseminated encephalomyelitis is a monophasic demyelinating disorder of the central nervous system associated with various viral infections including HIV infection.[ncbi.nlm.nih.gov] ( Table 3 ) HIV-associated neurocognitive disorders, neuropathy, radiculopathy, myelopathy Primary central nervous system lymphoma Cryptococcus neoformans, CMV, JC virus,[aafp.org]

  • Lupus Erythematosus

    The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com] […] of the central nervous system 54 Changes or disorders of the mucous membranes 54 Disorders of the digestive system 47 Pleurisy 37 Disease of the lymphatic nodes 32 Pericarditis[lupus-selbsthilfe.de] The signs and symptoms of SLE vary among affected individuals, and can involve many organs and systems, including the skin, joints, kidneys, lungs, central nervous system,[ghr.nlm.nih.gov]

  • Familial Hemophagocytic Lymphohistiocytosis

    […] expression of tumor necrosis factor-alpha and interferon-gamma, leading to increased macrophage activation.[healio.com] Adult specialists should consider FHL in the differential diagnosis of patients with cytopenia and liver or central nervous system disorders, especially when a lymphoproliferative[ncbi.nlm.nih.gov] , hepatosplenomegaly, cytopenia and sometimes central nervous system involvement.[journals.plos.org]

  • Childhood Dermatomyositis

    Activation of dendritic cells with upregulation of genes induced by type-1 interferon (alpha) in muscle and peripheral blood seems to be central to disease pathogenesis.[ncbi.nlm.nih.gov] , involuntary weight loss), genitourinary (interstitial cystitis, renal tubular acidosis), skin (purpura, vasculitis,), neurologic (central nervous system disorders, cranial[ssa.gov] […] dermatomyositis; HLA B8-DRB1*0301 ancestral haplotype is a strong immunogenetic risk factor, and antecedent infections and birth seasonality suggest that environmental stimuli might increase[ncbi.nlm.nih.gov]

  • Singleton Merten Syndrome

    Laboratory evaluation shows increased alpha-interferon ( IFNA1 ) activity with upregulation of interferon signaling and interferon-stimulated gene expression.[mendelian.co] Williams Syndrome : A development disorder affecting vascular, connective tissue, and the central nervous system. ...[accessanesthesiology.mhmedical.com]

  • Local Lupus Erythematosus

    The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com] Seizures or psychosis (organic mental syndrome), though rare, are the most characteristic central nervous system (CNS) manifestations of the disease and as such have been[rheumatologyadvisor.com] Reports pointing to important roles of interferon-alpha, transcription factors, and signaling variations also point to a central role for neutrophils. [21] Genetics There[emedicine.medscape.com]

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