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18 Possible Causes for Alpha Interferon Activity Increased, Central Nervous System Disorder, Thrombocytopenia

  • Infectious Mononucleosis

    They include Granulocytopenia Thrombocytopenia Hemolytic anemia Transient mild granulocytopenia or thrombocytopenia occurs in about 50% of patients; severe cases, associated[merck.com] Th1 lineage mostly produce type 2 interleukin (IL-2), interferon-gamma (INF-γ) and tumor necrosis factor-alpha (TNF-α).[omicsonline.org] nervous system lymphomas.[3][4] The virus is also associated with the childhood disorders of Alice in Wonderland syndrome[5] and acute cerebellar ataxia[6] and, based on[en.wikipedia.org]

  • Systemic Lupus Erythematosus

    Background While thrombopoeitin (TPO) agonists that act to simulate platelet production have been approved for use in steroid-refractory chronic immune thrombocytopenia purpura[ncbi.nlm.nih.gov] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.com] Abstract Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disorder that can involve any organ system.[ncbi.nlm.nih.gov]

  • Lupus Erythematosus

    […] autoimmune thrombocytopenia).[merckmanuals.com] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com] […] of the central nervous system 54 Changes or disorders of the mucous membranes 54 Disorders of the digestive system 47 Pleurisy 37 Disease of the lymphatic nodes 32 Pericarditis[lupus-selbsthilfe.de]

  • HIV Infection

    As part of the work up for thrombocytopenia, a rapid HIV antibody based assay was done and was negative.[ncbi.nlm.nih.gov] […] are not generally increased, although expression of IL-1, IL-2, IL-6, IL-12, and interferon-gamma may be elevated.(112) With administration of antiretroviral therapies, these[hivinsite.ucsf.edu] Acute disseminated encephalomyelitis is a monophasic demyelinating disorder of the central nervous system associated with various viral infections including HIV infection.[ncbi.nlm.nih.gov]

  • Familial Hemophagocytic Lymphohistiocytosis

    Other significant findings include hepatosplenomegaly, progressive anemia, leukopenia, thrombocytopenia, hyperlipidemia and hypofibrinogenemia.[ncbi.nlm.nih.gov] […] expression of tumor necrosis factor-alpha and interferon-gamma, leading to increased macrophage activation.[healio.com] Adult specialists should consider FHL in the differential diagnosis of patients with cytopenia and liver or central nervous system disorders, especially when a lymphoproliferative[ncbi.nlm.nih.gov]

  • Malignant Angioendotheliomatosis

    Her serum protein normalized; however, extensive edema persisted, and the degree of thrombocytopenia became severe.[myslide.es] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com] After an unmaintained 8-month clinical remission, the patient had central nervous system relapse and died.[ncbi.nlm.nih.gov]

  • Local Lupus Erythematosus

    […] autoimmune thrombocytopenia).[merckmanuals.com] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com] Seizures or psychosis (organic mental syndrome), though rare, are the most characteristic central nervous system (CNS) manifestations of the disease and as such have been[rheumatologyadvisor.com]

  • Singleton Merten Syndrome

    Necrolysis 52 19 73 36 86 DERMATOLOGIC DISORDERS 93 DYSMORPHIC DISORDERS 141 98 58 129 SturgeWeber Syndrome 10 Asherman Syndrome 132 3M Syndrome 11 Bartter Syndrome 133 Thrombocytopenia[books.google.de] Laboratory evaluation shows increased alpha-interferon ( IFNA1 ) activity with upregulation of interferon signaling and interferon-stimulated gene expression.[mendelian.co] Williams Syndrome : A development disorder affecting vascular, connective tissue, and the central nervous system. ...[accessanesthesiology.mhmedical.com]

  • Cerebellotrigeminal Dermal Dysplasia

    Amegakaryocytic Thrombocytopenia, Radial Aplasia Thrombocytopenia Syndrome, Radial Aplasia- Amegakaryocytic Thrombocytopenia, TAR Syndrome Disease name: Tetralogy of Fallot[syndrome.medicclub.info] Laboratory evaluation shows increased alpha-interferon ( IFNA1 ) activity with upregulation of interferon signaling and interferon-stimulated gene expression.[mendelian.co] The clinical manifestations of central nervous system malformations are also discussed, along with new advancements in MRI techniques and analysis, including volumetric morphology[books.google.de]

  • Childhood Dermatomyositis

    Lymphoma, nausea, vomiting, hepatotoxicity, leukopenia, oral ulcers, thrombocytopenia Screen patients for thiopurine methyltransferase deficiency before therapy (0.3 to 11[aafp.org] Activation of dendritic cells with upregulation of genes induced by type-1 interferon (alpha) in muscle and peripheral blood seems to be central to disease pathogenesis.[ncbi.nlm.nih.gov] , involuntary weight loss), genitourinary (interstitial cystitis, renal tubular acidosis), skin (purpura, vasculitis,), neurologic (central nervous system disorders, cranial[ssa.gov]

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