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12 Possible Causes for Alpha Interferon Activity Increased, Complete Blood Count Abnormal

  • Infectious Mononucleosis

    Other tests your doctor might order include a complete blood count (CBC) to see if your blood platelet count is lower than normal and if lymphocytes are abnormal, and a chemistry[encyclopedia.com] Th1 lineage mostly produce type 2 interleukin (IL-2), interferon-gamma (INF-γ) and tumor necrosis factor-alpha (TNF-α).[omicsonline.org] In EBV infection levels of abnormal circulating Th1 lymphocytes are increased, leading to activation of cell-mediated immunity.[omicsonline.org]

  • Alcoholic Hepatitis

    In addition, the following diagnostic procedures are employed for detecting liver damage: Complete blood count to determine presence of anemia and other abnormalities.[symptoma.com] We analyzed clinical, biological, virological and histological features in two cases where alpha-interferon treatment for HCV-related hepatitis led to a marked increase in[ncbi.nlm.nih.gov] . – Mild elevation in alkaline phosphatase Albumin (frequent hypoalbuminemia) Prothrombin time/international normalized ratio (INR) (frequent coagulopathy) Complete blood[clinicaladvisor.com]

  • Systemic Lupus Erythematosus

    Each of these are detectable with standard complete blood count testing ( CBC ).[medicinenet.com] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.com] count (RBC), or platelet count on routine complete blood count testing; leukopenia, anemia , and thrombocytopenia, respectively.[medicinenet.com]

  • Renal Cell Carcinoma

    Beta-D-glucans may promote dendritic cell (DC) maturation; increase interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha) and immunoglobulin levels; and may[cancer.gov] […] enhance natural killer (NK) cell activity, potentially boosting anti-tumor host immune responses.[cancer.gov] […] extract A dietary supplement containing an extract of the Basidiomycete fungus Agaricus blazei Murill with potential chemopreventive, antineoplastic and immunopotentiating activities[cancer.gov]

  • Mycobacterium Avium Complex

    Complete blood counts (CBC’s) and complete metabolic panels (CMP’s) may be abnormal. Low red blood cell counts (anemia) are quite common.[maclungdisease.org] Individuals with localized pulmonary MAC infections showed increased activation of monocytes and enhanced monocyte and T-cell tumor necrosis factor alpha (TNF-alpha) production[ncbi.nlm.nih.gov] Genomic DNA from the individual with the brain MAC infection was studied for gamma interferon (IFN-gamma) receptor mutations.[ncbi.nlm.nih.gov]

  • Viral Pneumonia

    Retrospective observational reports of combination treatment with ribavirin and pegylated interferon alpha have shown inconsistent results.[clinicaladvisor.com] Adjunct corticosteroids are not recommended and may increase mortality. Mycophenolate demonstrates in vitro activity but was not effective in animal models.[clinicaladvisor.com]

  • Childhood Dermatomyositis

    Activation of dendritic cells with upregulation of genes induced by type-1 interferon (alpha) in muscle and peripheral blood seems to be central to disease pathogenesis.[ncbi.nlm.nih.gov] […] dermatomyositis; HLA B8-DRB1*0301 ancestral haplotype is a strong immunogenetic risk factor, and antecedent infections and birth seasonality suggest that environmental stimuli might increase[ncbi.nlm.nih.gov]

  • Zinc Deficiency

    Her complete blood cell count with differential was normal, ferritin concentration level was 110 ng/mL (reference, 40-200 ng/mL), iron level was 75 microg/dL (reference, 35[ncbi.nlm.nih.gov] Zinc increases the activity of the human cytokine interferon alpha responsible for preventing viral replication.[thetruthaboutcancer.com] Laboratory workup showed normal electrolytes, blood urea nitrogen, creatinine, and blood sugar levels.[ncbi.nlm.nih.gov]

  • Lupus Erythematosus

    Each of these are detectable with standard complete blood count testing ( CBC ).[medicinenet.com] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com] […] results if SLE is suspected: Complete Blood Count: This blood test reveals a patient's total number of red blood cells, white blood cells, platelets, and hemoglobin.[physio-pedia.com]

  • Drug-Induced Lupus Erythematosus

    DILE is less likely to show anemia or thrombocytopenia on complete blood count, a decrease in C3 and C4 levels, or abnormalities of the liver and kidney function tests and[ncbi.nlm.nih.gov] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.com] complete blood count, leukopenia, thrombocytopenia, positive antinuclear antibodies (ANAs), and lupus erythematosus tests.[consultant360.com]

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