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14 Possible Causes for Alpha Interferon Activity Increased, Complete Blood Count Abnormal, Thrombocytopenia

  • Infectious Mononucleosis

    They include Granulocytopenia Thrombocytopenia Hemolytic anemia Transient mild granulocytopenia or thrombocytopenia occurs in about 50% of patients; severe cases, associated[merck.com] Other tests your doctor might order include a complete blood count (CBC) to see if your blood platelet count is lower than normal and if lymphocytes are abnormal, and a chemistry[encyclopedia.com] Th1 lineage mostly produce type 2 interleukin (IL-2), interferon-gamma (INF-γ) and tumor necrosis factor-alpha (TNF-α).[omicsonline.org]

  • Systemic Lupus Erythematosus

    Background While thrombopoeitin (TPO) agonists that act to simulate platelet production have been approved for use in steroid-refractory chronic immune thrombocytopenia purpura[ncbi.nlm.nih.gov] Each of these are detectable with standard complete blood count testing ( CBC ).[medicinenet.com] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com]

  • Alcoholic Hepatitis

    These findings suggest that PAIgG may have been involved in the development of thrombocytopenia in this patient.[ncbi.nlm.nih.gov] In addition, the following diagnostic procedures are employed for detecting liver damage: Complete blood count to determine presence of anemia and other abnormalities.[symptoma.com] We analyzed clinical, biological, virological and histological features in two cases where alpha-interferon treatment for HCV-related hepatitis led to a marked increase in[ncbi.nlm.nih.gov]

  • Lupus Erythematosus

    […] autoimmune thrombocytopenia).[merckmanuals.com] Each of these are detectable with standard complete blood count testing ( CBC ).[medicinenet.com] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com]

  • Mycobacterium Avium Complex

    Both leukocytopenia and thrombocytopenia had been noted in the patient's 19-year-old younger brother, who had been living in the same home 5 years earlier, and for whom a[ncbi.nlm.nih.gov] Complete blood counts (CBC’s) and complete metabolic panels (CMP’s) may be abnormal. Low red blood cell counts (anemia) are quite common.[maclungdisease.org] Individuals with localized pulmonary MAC infections showed increased activation of monocytes and enhanced monocyte and T-cell tumor necrosis factor alpha (TNF-alpha) production[ncbi.nlm.nih.gov]

  • Renal Cell Carcinoma

    Grade 3 or 4 events were for hand-foot syndrome 16%, thrombocytopenia 16% and stomatitis 10% ( 3 ). 3.1.[intjcancermanag.com] Beta-D-glucans may promote dendritic cell (DC) maturation; increase interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha) and immunoglobulin levels; and may[cancer.gov] In a pooled analysis of VOTRIENT clinical trials, East Asian patients had a higher frequency of neutropenia, thrombocytopenia, and palmar-plantar erythrodysesthesia syndrome[hcp.novartis.com]

  • Childhood Dermatomyositis

    Lymphoma, nausea, vomiting, hepatotoxicity, leukopenia, oral ulcers, thrombocytopenia Screen patients for thiopurine methyltransferase deficiency before therapy (0.3 to 11[aafp.org] Activation of dendritic cells with upregulation of genes induced by type-1 interferon (alpha) in muscle and peripheral blood seems to be central to disease pathogenesis.[ncbi.nlm.nih.gov] Hematologic abnormalities, such as anemia, granulocytopenia, and thrombocytopenia, under 107.00. i.[ssa.gov]

  • Viral Pneumonia

    IV acyclovir may cause seizures, leukopenia, thrombocytopenia, and renal impairment.[clinicaladvisor.com] Increased hematocrit and thrombocytopenia were signs strongly suggestive of the disease.[scielo.br] Retrospective observational reports of combination treatment with ribavirin and pegylated interferon alpha have shown inconsistent results.[clinicaladvisor.com]

  • Drug-Induced Lupus Erythematosus

    In conclusion, physicians should be alert to the possibility of DILE in patients presenting with thrombocytopenia under a capecitabine and bevacizumab chemotherapy regimen[ncbi.nlm.nih.gov] DILE is less likely to show anemia or thrombocytopenia on complete blood count, a decrease in C3 and C4 levels, or abnormalities of the liver and kidney function tests and[ncbi.nlm.nih.gov] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.com]

  • Malignant Angioendotheliomatosis

    Her serum protein normalized; however, extensive edema persisted, and the degree of thrombocytopenia became severe.[myslide.es] Routine biochemical analysis, complete blood count, and urine microscopy were all normal, and the erythrocyte sedimentation rate was 8 mm/h.[scielo.br] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com]

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