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954 Possible Causes for Alpha Interferon Activity Increased, Distal Renal Tubular Acidosis

  • Systemic Lupus Erythematosus

    The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.com] Reports pointing to important roles of interferon-alpha, transcription factors, and signaling variations also point to a central role for neutrophils. [21] Genetics There[emedicine.com]

  • Chronic Active Hepatitis B

    CONCLUSIONS: alpha-interferon therapy for patients with chronic active hepatitis B is cost effective. alpha-Interferon is more cost effective in toddlers than adults because[ncbi.nlm.nih.gov] […] of the smaller dose required and the greater increase in life expectancy of children.[ncbi.nlm.nih.gov]

  • Chronic Active Hepatitis

    CONCLUSIONS: alpha-interferon therapy for patients with chronic active hepatitis B is cost effective. alpha-Interferon is more cost effective in toddlers than adults because[ncbi.nlm.nih.gov] At the time of the hemorrhage, plasma-activated complement 5, a known potent intravascular aggregator of granulocytes, increased to 54 ng/ml in one patient and to 29 ng/ml[ncbi.nlm.nih.gov] […] of the smaller dose required and the greater increase in life expectancy of children.[ncbi.nlm.nih.gov]

  • Hashimoto Thyroiditis

    History Hypothyroidism is usually insidious in onset, with signs and symptoms slowly progressing over months to years. Most commonly, patients do not relate a history suggestive of transient hyperthyroidism secondary to increased T4 and T3 levels resulting from thyrocyte destruction. The time course is influenced[…][emedicine.medscape.com]

    Missing: Alpha Interferon Activity Increased
  • Acidosis

    Other reasons for metabolic acidosis include – Kidney disease – with proximal or distal renal tubular acidosis Severe dehydration A high-fat plus low-carbohydrate diet Metabolic[symptoma.com] Mutations to the V-ATPase 'a4' or 'B1' isoforms result in distal renal tubular acidosis, a condition that leads to metabolic acidosis, in some cases with sensorineural deafness[en.wikipedia.org] Hyperchloraemic acidosis occurs with the loss of sodium bicarbonate from the body, e.g. sever diarrhoea or vomiting.[symptoma.com]

    Missing: Alpha Interferon Activity Increased
  • Hydronephrosis

    Impaired concentrating ability or elevated urine pH (distal renal tubular acidosis) are also commonly found due to tubular stress and injury.[en.wikipedia.org]

    Missing: Alpha Interferon Activity Increased
  • Nonallergic Interstitial Nephritis

    Distal renal tubular acidosis occurs rarely.[abdominalkey.com] Tubular injury may lead to proximal tubulopathy and even Fanconi-like syndrome (cidofovir, tenofovir, foscarnet), distal tubular acidosis (foscarnet) and nephrogenic diabetes[abdominalkey.com] Renal proximal tubular dysfunction is the most common effect, and features of Fanconi syndrome and related electrolyte abnormalities, which may be severe, have been reported[abdominalkey.com]

    Missing: Alpha Interferon Activity Increased
  • Sjogren's Syndrome

    Abstract Proton-secretory defect is thought to be a major pathophysiologic mechanism leading to classic distal renal tubular acidosis (dRTA).[ncbi.nlm.nih.gov] Renal manifestations such as distal renal tubular acidosis have well been described in primary SS.[degruyter.com] Renal involvement, which is found in approximately 5% of patients, is usually associated with tubulointerstitial changes which frequently go along with distal renal tubular[ncbi.nlm.nih.gov]

    Missing: Alpha Interferon Activity Increased
  • Primary Hyperparathyroidism

    renal tubular acidosis.[ncbi.nlm.nih.gov] Muthukrishnan J, Hari Kumar KV, Jha R, Jha S, Modi KD (2008) Distal renal tubular acidosis due to primary hyperparathyroidism.[link.springer.com] Distal renal tubular acidosis due to primary hyperparathyroidism is rarely reported.[ncbi.nlm.nih.gov]

    Missing: Alpha Interferon Activity Increased
  • Urinary Tract Obstruction

    Hyperkalemic distal renal tubular acidosis associated with obstructive uropathy. N Engl J Med . 1981 Feb 12. 304(7):373-80. [Medline] . Becker A, Baum M.[emedicine.medscape.com] Hyperkalemic distal renal tubular acidosis associated with obstructive uropathy. N Engl J Med. 1981 Feb 12. 304(7):373-80. [Medline]. Becker A, Baum M.[emedicine.medscape.com]

    Missing: Alpha Interferon Activity Increased

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