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14 Possible Causes for Alpha Interferon Activity Increased, Easy Bruising, Thrombocytopenia

  • Systemic Lupus Erythematosus

    Background While thrombopoeitin (TPO) agonists that act to simulate platelet production have been approved for use in steroid-refractory chronic immune thrombocytopenia purpura[ncbi.nlm.nih.gov] bruising Anxiety Depression Memory loss[web.archive.org] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.com]

  • Familial Hemophagocytic Lymphohistiocytosis

    Other significant findings include hepatosplenomegaly, progressive anemia, leukopenia, thrombocytopenia, hyperlipidemia and hypofibrinogenemia.[ncbi.nlm.nih.gov] A reduction in platelets may cause easy bruising and abnormal bleeding.The brain may also be affected in familial hemophagocytic lymphohistiocytosis.[icdlist.com] […] expression of tumor necrosis factor-alpha and interferon-gamma, leading to increased macrophage activation.[healio.com]

  • Lupus Erythematosus

    […] autoimmune thrombocytopenia).[merckmanuals.com] Sometimes changes in blood counts may contribute to symptoms of fatigue (low red blood cell count, anemia), serious infections (low white blood cell count), or easy bruising[my.clevelandclinic.org] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com]

  • Alcoholic Hepatitis

    These findings suggest that PAIgG may have been involved in the development of thrombocytopenia in this patient.[ncbi.nlm.nih.gov] […] deficiency) Endocrine Gynaecomastia Testicular atrophy Loss of body hair Signs of ‘pseudo- Cushings ’ (red face, hump, striae) Face /skin Parotid enlargement Spider naevi Easy[almostadoctor.co.uk] We analyzed clinical, biological, virological and histological features in two cases where alpha-interferon treatment for HCV-related hepatitis led to a marked increase in[ncbi.nlm.nih.gov]

  • Waters-West Syndrome

    The most common cause of thrombocytopenia during pregnancy is gestational thrombocytopenia, which is a mild thrombocytopenia with platelet levels remaining above 70,000/µL[emedicine.medscape.com] Laboratory evaluation shows increased alpha-interferon ( IFNA1 ) activity with upregulation of interferon signaling and interferon-stimulated gene expression.[mendelian.co] Clinical features include THROMBOCYTOPENIA; HEMOLYTIC ANEMIA ; AZOTEMIA; FEVER; and thrombotic microangiopathy.[ncbi.nlm.nih.gov]

  • Drug-Induced Lupus Erythematosus

    In conclusion, physicians should be alert to the possibility of DILE in patients presenting with thrombocytopenia under a capecitabine and bevacizumab chemotherapy regimen[ncbi.nlm.nih.gov] A low platelet count can lead to easy bruising, nosebleeds, and other bleeding. It can also cause your blood to clot too easily or in unneeded places.[familydoctor.org] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.com]

  • Chronic Active Hepatitis

    Onset was signalled by an abrupt and dramatic thrombocytopenia, which was also the only laboratory parameter able to monitor treatment and progression of the disease.[ncbi.nlm.nih.gov] […] bleeding or bruising The symptoms of alcoholic hepatitis are similar to those caused by other health conditions.[healthline.com] CONCLUSIONS: alpha-interferon therapy for patients with chronic active hepatitis B is cost effective. alpha-Interferon is more cost effective in toddlers than adults because[ncbi.nlm.nih.gov]

  • Malignant Angioendotheliomatosis

    Her serum protein normalized; however, extensive edema persisted, and the degree of thrombocytopenia became severe.[myslide.es] Continued Sometimes, changes in blood counts (low red cell count, or anemia), may cause fatigue, serious infections (low white cell count), or easy bruising or bleeding (low[webmd.com] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com]

  • Lentigo Maligna Melanoma

    People may have low blood counts, including a low red blood cell count (anemia), a low white blood cell count (leukopenia), and a low platelet count (thrombocytopenia).[cdc.gov] bruising, depending on the drug used In cases, where the melanoma is advanced, but remains confined to an arm or leg; chemotherapy is only circulated through the affected[dovemed.com] TLR7 activates the T-helper 1 response and increases the production of pro-inflammatory cytokines such as interferon alpha, tumor necrosis factor alpha, and interleukin (IL[synapse.koreamed.org]

  • Renal Cell Carcinoma

    Grade 3 or 4 events were for hand-foot syndrome 16%, thrombocytopenia 16% and stomatitis 10% ( 3 ). 3.1.[intjcancermanag.com] Chemotherapy can also suppress production of new blood cells, leading to fatigue, anemia, easy bruising or bleeding, and increased risk of infection.[emedicinehealth.com] Beta-D-glucans may promote dendritic cell (DC) maturation; increase interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha) and immunoglobulin levels; and may[cancer.gov]

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