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19 Possible Causes for Alpha Interferon Activity Increased, Elevated Sedimentation Rate, Thrombocytopenia

  • Systemic Lupus Erythematosus

    Background While thrombopoeitin (TPO) agonists that act to simulate platelet production have been approved for use in steroid-refractory chronic immune thrombocytopenia purpura[ncbi.nlm.nih.gov] Initial labs showed pancytopenia, bandemia, proteinuria, elevated erythrocyte sedimentation rate, and elevated d-dimer.[ncbi.nlm.nih.gov] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.com]

  • Chronic Active Hepatitis

    Onset was signalled by an abrupt and dramatic thrombocytopenia, which was also the only laboratory parameter able to monitor treatment and progression of the disease.[ncbi.nlm.nih.gov] […] erythrocyte sedimentation rate Eosinophilia (uncommon) Biopsy Urgent liver biopsy, transjugular if appropriate, may help to confirm the clinical suspicion of acute autoimmune[emedicine.medscape.com] CONCLUSIONS: alpha-interferon therapy for patients with chronic active hepatitis B is cost effective. alpha-Interferon is more cost effective in toddlers than adults because[ncbi.nlm.nih.gov]

  • Infectious Mononucleosis

    They include Granulocytopenia Thrombocytopenia Hemolytic anemia Transient mild granulocytopenia or thrombocytopenia occurs in about 50% of patients; severe cases, associated[merck.com] Erythrocyte sedimentation rate (ESR) is often elevated in patients with infectious mononucleosis but is usually within normal limits in patients with group A streptococcal[symptoma.com] Th1 lineage mostly produce type 2 interleukin (IL-2), interferon-gamma (INF-γ) and tumor necrosis factor-alpha (TNF-α).[omicsonline.org]

  • Lupus Erythematosus

    […] autoimmune thrombocytopenia).[merckmanuals.com] The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.[fpnotebook.com] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com]

  • Alcoholic Hepatitis

    These findings suggest that PAIgG may have been involved in the development of thrombocytopenia in this patient.[ncbi.nlm.nih.gov] We analyzed clinical, biological, virological and histological features in two cases where alpha-interferon treatment for HCV-related hepatitis led to a marked increase in[ncbi.nlm.nih.gov] […] based on clinical symptoms and laboratory finding alone including elevated AST/ALT (but may 300 IU/mL), AST ALT of 2, Total serum bilirubin 5mg/deciliter, elevated INR, thrombocytopenia[bloodjournal.org]

  • Renal Cell Carcinoma

    Grade 3 or 4 events were for hand-foot syndrome 16%, thrombocytopenia 16% and stomatitis 10% ( 3 ). 3.1.[intjcancermanag.com] sedimentation rate 30 mm/h, γ 2 -globulin 10%, and especially pyrexia have rapid growth, and their prognosis is considered to be poor.[journals.sagepub.com] Beta-D-glucans may promote dendritic cell (DC) maturation; increase interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha) and immunoglobulin levels; and may[cancer.gov]

  • Drug-Induced Lupus Erythematosus

    In conclusion, physicians should be alert to the possibility of DILE in patients presenting with thrombocytopenia under a capecitabine and bevacizumab chemotherapy regimen[ncbi.nlm.nih.gov] An elevated erythrocyte sedimentation rate (ESR 80%) may also be present. The absence of renal or central nervous system involvement is more suggestive of DILE.[the-hospitalist.org] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.com]

  • Chronic Active Hepatitis B

    Diseases commonly seen with autoimmune hepatitis include hemolytic anemia, immune thrombocytopenia, type 1 diabetes mellitus, thyroiditis, celiac sprue, ulcerative colitis[clinicaladvisor.com] Aspartate aminotransferase and alanine aminotransferase levels were elevated (47 and 85 U/mL, respectively), but the erythrocyte sedimentation rate, and blood urea nitrogen[synapse.koreamed.org] CONCLUSIONS: alpha-interferon therapy for patients with chronic active hepatitis B is cost effective. alpha-Interferon is more cost effective in toddlers than adults because[ncbi.nlm.nih.gov]

  • Childhood Dermatomyositis

    Lymphoma, nausea, vomiting, hepatotoxicity, leukopenia, oral ulcers, thrombocytopenia Screen patients for thiopurine methyltransferase deficiency before therapy (0.3 to 11[aafp.org] Laboratory studies showed an elevated erythrocyte sedimentation rate of 24 mm/h. Blood work up revealed normal levels of calcium, phosphorus and PTH.[ijdvl.com] Activation of dendritic cells with upregulation of genes induced by type-1 interferon (alpha) in muscle and peripheral blood seems to be central to disease pathogenesis.[ncbi.nlm.nih.gov]

  • Intestinal Tuberculosis

    The initial management of thrombocytopenia, with steroids and intravenous immunoglobulin, was not successful, and the lack of tuberculosis symptoms hampered a proper diagnostic[ncbi.nlm.nih.gov] DIAGNOSIS Laboratory tests Anaemia, lymphocytosis, and an elevated erythrocyte sedimentation rate are common in patients with tuberculosis.[ots1.narod.ru] Expression of growth-related oncogene-alpha was increased in intestinal TB, while expression of interferon-gamma (IFN-) and TLR 4, 5 and 9 was increased in Crohn's disease[ncbi.nlm.nih.gov]

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