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36 Possible Causes for Alpha Interferon Activity Increased, Fatigue, Thrombocytopenia

  • Infectious Mononucleosis

    They include Granulocytopenia Thrombocytopenia Hemolytic anemia Transient mild granulocytopenia or thrombocytopenia occurs in about 50% of patients; severe cases, associated[merck.com] A diagnosis of chronic fatigue syndrome (CFS) was made according to the international diagnostic criteria [ 13 ] in post-infective fatigue cases included in this study.[dx.doi.org] Th1 lineage mostly produce type 2 interleukin (IL-2), interferon-gamma (INF-γ) and tumor necrosis factor-alpha (TNF-α).[omicsonline.org]

  • Systemic Lupus Erythematosus

    Background While thrombopoeitin (TPO) agonists that act to simulate platelet production have been approved for use in steroid-refractory chronic immune thrombocytopenia purpura[ncbi.nlm.nih.gov] Medication usage did not predict fatigue levels. Pain and depression were both unique positive predictors of fatigue.[ncbi.nlm.nih.gov] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com]

  • HIV Infection

    As part of the work up for thrombocytopenia, a rapid HIV antibody based assay was done and was negative.[ncbi.nlm.nih.gov] Alisa Le For years, I was plagued by chronic yeast infections, including but not limited to: rashes, weight gain, insomnia, acne, constipation, chronic fatigue, depression[slideshare.net] […] are not generally increased, although expression of IL-1, IL-2, IL-6, IL-12, and interferon-gamma may be elevated.(112) With administration of antiretroviral therapies, these[hivinsite.ucsf.edu]

  • Lupus Erythematosus

    […] autoimmune thrombocytopenia).[merckmanuals.com] […] elimination of antibodies, circulation and tissue deposition of immune complexes, and complement and cytokine activation contribute to clinical manifestations that range from mild fatigue[doi.org] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com]

  • Drug-Induced Lupus Erythematosus

    In conclusion, physicians should be alert to the possibility of DILE in patients presenting with thrombocytopenia under a capecitabine and bevacizumab chemotherapy regimen[ncbi.nlm.nih.gov] We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition. Last updated: May 13, 2019[patientslikeme.com] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.com]

  • Malignant Angioendotheliomatosis

    Her serum protein normalized; however, extensive edema persisted, and the degree of thrombocytopenia became severe.[myslide.es] The general signs and symptoms may include weight loss, fatigue, headaches, and frequent infections.[dovemed.com] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com]

  • Myocarditis

    Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral infectious disease with high mortality.[ncbi.nlm.nih.gov] Of note, she had complained of fatigue, feeling constitutionally unwell and a generalised rash in the days prior to her presentation.[ncbi.nlm.nih.gov] The possible modes of action include enhancing natural killer cell activity, inducing production of alpha‐ and gamma‐interferon, improving cardiac microcirculation, and activity[doi.org]

  • Renal Cell Carcinoma

    Grade 3 or 4 events were for hand-foot syndrome 16%, thrombocytopenia 16% and stomatitis 10% ( 3 ). 3.1.[intjcancermanag.com] A 70-Year-Old African-American Woman with Metastatic RCC December 2017 A 70-year-old African-American woman presented to her PCP with loss of appetite, fatigue, abdominal[targetedonc.com] Beta-D-glucans may promote dendritic cell (DC) maturation; increase interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha) and immunoglobulin levels; and may[cancer.gov]

  • Mycobacterium Avium Complex

    Both leukocytopenia and thrombocytopenia had been noted in the patient's 19-year-old younger brother, who had been living in the same home 5 years earlier, and for whom a[ncbi.nlm.nih.gov] Signs and symptoms include bacteremia, fever, chills, fatigue, night sweats, weight loss, abdominal pain, anemia, and elevated alkaline phosphatase.[medical-dictionary.thefreedictionary.com] Individuals with localized pulmonary MAC infections showed increased activation of monocytes and enhanced monocyte and T-cell tumor necrosis factor alpha (TNF-alpha) production[ncbi.nlm.nih.gov]

  • Local Lupus Erythematosus

    […] autoimmune thrombocytopenia).[merckmanuals.com] Employees Overview Research outputs Projects Activities Fatigue and psychological states and traits in systemic lupus erythematosus: association or causation?[pure.au.dk] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com]

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