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15 Possible Causes for Alpha Interferon Activity Increased, Fibromyalgia, Thrombocytopenia

  • Infectious Mononucleosis

    They include Granulocytopenia Thrombocytopenia Hemolytic anemia Transient mild granulocytopenia or thrombocytopenia occurs in about 50% of patients; severe cases, associated[merck.com] Th1 lineage mostly produce type 2 interleukin (IL-2), interferon-gamma (INF-γ) and tumor necrosis factor-alpha (TNF-α).[omicsonline.org] Corticosteroids may have a role in hastening resolution of some complications, especially upper airway obstruction and possibly immune-mediated anemia and thrombocytopenia[oadoi.org]

  • Systemic Lupus Erythematosus

    Background While thrombopoeitin (TPO) agonists that act to simulate platelet production have been approved for use in steroid-refractory chronic immune thrombocytopenia purpura[ncbi.nlm.nih.gov] The scores in all eight domains of the SF-36 were lower in SLE patients with fibromyalgia than in patients without fibromyalgia and HCs.[ncbi.nlm.nih.gov] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.com]

  • Lupus Erythematosus

    […] autoimmune thrombocytopenia).[merckmanuals.com] The scores in all eight domains of the SF-36 were lower in SLE patients with fibromyalgia than in patients without fibromyalgia and HCs.[ncbi.nlm.nih.gov] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com]

  • Drug-Induced Lupus Erythematosus

    In conclusion, physicians should be alert to the possibility of DILE in patients presenting with thrombocytopenia under a capecitabine and bevacizumab chemotherapy regimen[ncbi.nlm.nih.gov] Secondary fibromyalgia is common. Raynaud's phenomenon occurs in about one fifth of patients but is often mild. Mucocutaneous: Photosensitivity rash.[patient.info] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.com]

  • Waters-West Syndrome

    The most common cause of thrombocytopenia during pregnancy is gestational thrombocytopenia, which is a mild thrombocytopenia with platelet levels remaining above 70,000/µL[emedicine.medscape.com] […] analysis and, preferably, molecular diagnostics since GHB is employed in illicit settings, as well as in an increasing number of clinical situations, including narcolepsy, fibromyalgia[rarediseasesnetwork.org] Laboratory evaluation shows increased alpha-interferon ( IFNA1 ) activity with upregulation of interferon signaling and interferon-stimulated gene expression.[mendelian.co]

  • Local Lupus Erythematosus

    […] autoimmune thrombocytopenia).[merckmanuals.com] It is common that patients will be diagnosed with some of the above connective tissue diseases or other conditions such as fibromyalgia or chronic fatigue syndrome before[mollysfund.org] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com]

  • Chronic Active Hepatitis

    Onset was signalled by an abrupt and dramatic thrombocytopenia, which was also the only laboratory parameter able to monitor treatment and progression of the disease.[ncbi.nlm.nih.gov] Some patients develop pain in small joints in the body (such as the hand) that may be nearly indistinguishable from symptoms of rheumatoid arthritis, fibromyalgia, or carpal[skylinefamilypractice.net] CONCLUSIONS: alpha-interferon therapy for patients with chronic active hepatitis B is cost effective. alpha-Interferon is more cost effective in toddlers than adults because[ncbi.nlm.nih.gov]

  • Malignant Angioendotheliomatosis

    Her serum protein normalized; however, extensive edema persisted, and the degree of thrombocytopenia became severe.[myslide.es] As in many other chronic diseases, the prevalence of fibromyalgia is increased, which may cause diagnostic confusion in patients with periarticular and generalized pain and[merckmanuals.com] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com]

  • Childhood Dermatomyositis

    Lymphoma, nausea, vomiting, hepatotoxicity, leukopenia, oral ulcers, thrombocytopenia Screen patients for thiopurine methyltransferase deficiency before therapy (0.3 to 11[aafp.org] His rheumatologist said he has seen a few cases of children with JDM and Fibromyalgia.[globalgenes.org] Activation of dendritic cells with upregulation of genes induced by type-1 interferon (alpha) in muscle and peripheral blood seems to be central to disease pathogenesis.[ncbi.nlm.nih.gov]

  • Myocarditis

    Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral infectious disease with high mortality.[ncbi.nlm.nih.gov] Spinal nerve problem Fibromyalgia Chest wall problems Radiculopathy Precordial catch syndrome - another benign and harmless form of a sharp, localized chest pain often mistaken[en.wikipedia.org] The possible modes of action include enhancing natural killer cell activity, inducing production of alpha‐ and gamma‐interferon, improving cardiac microcirculation, and activity[doi.org]

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