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22 Possible Causes for Alpha Interferon Activity Increased, Glomerulonephritis, Thrombocytopenia

  • Infectious Mononucleosis

    Organ involved Symptoms and signs Spleen Splenomegaly (an enlarged spleen) Joints Arthritis in one or more joints Kidneys Glomerulonephritis Nervous system Meningoencephalitis[dermnetnz.org] They include Granulocytopenia Thrombocytopenia Hemolytic anemia Transient mild granulocytopenia or thrombocytopenia occurs in about 50% of patients; severe cases, associated[merck.com] Th1 lineage mostly produce type 2 interleukin (IL-2), interferon-gamma (INF-γ) and tumor necrosis factor-alpha (TNF-α).[omicsonline.org]

  • Systemic Lupus Erythematosus

    Combinations of membranous and proliferative glomerulonephritis (i.e., class III and V or class IV and V) should be reported individually in the diagnostic line.[ncbi.nlm.nih.gov] Background While thrombopoeitin (TPO) agonists that act to simulate platelet production have been approved for use in steroid-refractory chronic immune thrombocytopenia purpura[ncbi.nlm.nih.gov] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com]

  • Lupus Erythematosus

    […] effusion, pulmonary fibrosis NEUROLOGICAL: cranial and peripheral nerve lesions, transverse myelitis - weakness and paraplegia, depression, psychosis, seizures, CVA RENAL: glomerulonephritis[lifeinthefastlane.com] […] autoimmune thrombocytopenia).[merckmanuals.com] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com]

  • Drug-Induced Lupus Erythematosus

    Systemic lupus erythematosus (sle) Systemic lupus erythematosus (sle) with endocarditis Systemic lupus erythematosus (sle) with polyneuropathy Systemic lupus erythematosus glomerulonephritis[icd9data.com] In conclusion, physicians should be alert to the possibility of DILE in patients presenting with thrombocytopenia under a capecitabine and bevacizumab chemotherapy regimen[ncbi.nlm.nih.gov] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.com]

  • Waters-West Syndrome

    Bones OMIM:608709 Lipodystrophy, Partial, Acquired, Susceptibility To; APLD OMIM:613913 Lipodystrophy, Partial, Acquired, with Low Complement Component C3, with or without Glomerulonephritis[informatics.jax.org] The most common cause of thrombocytopenia during pregnancy is gestational thrombocytopenia, which is a mild thrombocytopenia with platelet levels remaining above 70,000/µL[emedicine.medscape.com] Laboratory evaluation shows increased alpha-interferon ( IFNA1 ) activity with upregulation of interferon signaling and interferon-stimulated gene expression.[mendelian.co]

  • Chronic Active Hepatitis

    The ultrastructural findings of renal biopsy suggested either cryoglobulinemic glomerulonephritis or immunotactoid glomerulopathy.[ncbi.nlm.nih.gov] Onset was signalled by an abrupt and dramatic thrombocytopenia, which was also the only laboratory parameter able to monitor treatment and progression of the disease.[ncbi.nlm.nih.gov] CONCLUSIONS: alpha-interferon therapy for patients with chronic active hepatitis B is cost effective. alpha-Interferon is more cost effective in toddlers than adults because[ncbi.nlm.nih.gov]

  • Local Lupus Erythematosus

    […] commonly involving the joints and the skin: symmetric arthritis in both large and small joints malar "butterfly" rash (considered characteristic) kidney disorders, most often glomerulonephritis[epilepsy.com] […] autoimmune thrombocytopenia).[merckmanuals.com] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com]

  • Chronic Active Hepatitis B

    Hepatitis B virus replication in acute glomerulonephritis with chronic active hepatitis.[adc.bmj.com] Diseases commonly seen with autoimmune hepatitis include hemolytic anemia, immune thrombocytopenia, type 1 diabetes mellitus, thyroiditis, celiac sprue, ulcerative colitis[clinicaladvisor.com] CONCLUSIONS: alpha-interferon therapy for patients with chronic active hepatitis B is cost effective. alpha-Interferon is more cost effective in toddlers than adults because[ncbi.nlm.nih.gov]

  • Malignant Angioendotheliomatosis

    Early lupus glomerulonephritis may be misdiagnosed as asymptomatic UTI. Obstetric manifestations include early and late fetal loss.[merckmanuals.com] Her serum protein normalized; however, extensive edema persisted, and the degree of thrombocytopenia became severe.[myslide.es] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com]

  • Alcoholic Hepatitis

    Anxiety Bipolar Depression Eating Disorder Obsessive Compulsive Disorder Pediatrics Psychosis Psychosomatic Acute Kidney Injury Chronic Kidney Disease Fluids & Electrolytes Glomerulonephritis[qxmd.com] These findings suggest that PAIgG may have been involved in the development of thrombocytopenia in this patient.[ncbi.nlm.nih.gov] We analyzed clinical, biological, virological and histological features in two cases where alpha-interferon treatment for HCV-related hepatitis led to a marked increase in[ncbi.nlm.nih.gov]

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