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13 Possible Causes for Alpha Interferon Activity Increased, Guillain-Barré Syndrome, Thrombocytopenia

  • Infectious Mononucleosis

    They include Granulocytopenia Thrombocytopenia Hemolytic anemia Transient mild granulocytopenia or thrombocytopenia occurs in about 50% of patients; severe cases, associated[merck.com] Epstein-Barr virus infection must be considered among the possible causes in patients with cranial nerve affection or Guillain-Barré syndrome.[dx.doi.org] Th1 lineage mostly produce type 2 interleukin (IL-2), interferon-gamma (INF-γ) and tumor necrosis factor-alpha (TNF-α).[omicsonline.org]

  • Systemic Lupus Erythematosus

    Background While thrombopoeitin (TPO) agonists that act to simulate platelet production have been approved for use in steroid-refractory chronic immune thrombocytopenia purpura[ncbi.nlm.nih.gov] He was clinically diagnosed with the acute motor and sensory axonal neuropathy variant of Guillain-Barré syndrome.[ncbi.nlm.nih.gov] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.com]

  • Lupus Erythematosus

    […] autoimmune thrombocytopenia).[merckmanuals.com] […] space-occupying lesion or ventricular enlargement, and normal cerebrospinal fluid chemical and hematological constituents. [36] More rare manifestations are acute confusional state, GuillainBarré[en.wikipedia.org] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com]

  • Waters-West Syndrome

    The most common cause of thrombocytopenia during pregnancy is gestational thrombocytopenia, which is a mild thrombocytopenia with platelet levels remaining above 70,000/µL[emedicine.medscape.com] Cardiobacteriaceae Cardiobacterium hominis HACEK Aeromonadales Aeromonas hydrophila / Aeromonas veronii Aeromonas infection ε Campylobacterales Campylobacter jejuni Campylobacteriosis, GuillainBarré[en.wikipedia.org] Laboratory evaluation shows increased alpha-interferon ( IFNA1 ) activity with upregulation of interferon signaling and interferon-stimulated gene expression.[mendelian.co]

  • Chronic Active Hepatitis B

    Diseases commonly seen with autoimmune hepatitis include hemolytic anemia, immune thrombocytopenia, type 1 diabetes mellitus, thyroiditis, celiac sprue, ulcerative colitis[clinicaladvisor.com] Guillain-Barré syndrome complicating acute hepatitis B. A case with detailed electrophysiological and immunological studies. Arch Neurol 1981;38:366–368. 4.[synapse.koreamed.org] CONCLUSIONS: alpha-interferon therapy for patients with chronic active hepatitis B is cost effective. alpha-Interferon is more cost effective in toddlers than adults because[ncbi.nlm.nih.gov]

  • Renal Cell Carcinoma

    Grade 3 or 4 events were for hand-foot syndrome 16%, thrombocytopenia 16% and stomatitis 10% ( 3 ). 3.1.[intjcancermanag.com] , Wegener's granulomatosis, Sjögren's syndrome, Guillain-Barré syndrome, multiple sclerosis, vasculitis, or glomerulonephritis.[clinicaltrials.gov] Beta-D-glucans may promote dendritic cell (DC) maturation; increase interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha) and immunoglobulin levels; and may[cancer.gov]

  • Myocarditis

    Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral infectious disease with high mortality.[ncbi.nlm.nih.gov] […] exclusion.[11] Around 2/3 of women experience shortness of breath as a part of a normal pregnancy.[8] Neurological conditions such as spinal cord injury, phrenic nerve injuries, GuillainBarré[en.wikipedia.org] The possible modes of action include enhancing natural killer cell activity, inducing production of alpha‐ and gamma‐interferon, improving cardiac microcirculation, and activity[doi.org]

  • Childhood Dermatomyositis

    Lymphoma, nausea, vomiting, hepatotoxicity, leukopenia, oral ulcers, thrombocytopenia Screen patients for thiopurine methyltransferase deficiency before therapy (0.3 to 11[aafp.org] Table 34 Differential Diagnosis of Polymyositis/Dermatomyositis Neuromuscular disease Myasthenia gravis Guillain-Barré syndrome Eaton-Lambert syndrome Muscular dystrophy Mitochondrial[rheumaknowledgy.com] Activation of dendritic cells with upregulation of genes induced by type-1 interferon (alpha) in muscle and peripheral blood seems to be central to disease pathogenesis.[ncbi.nlm.nih.gov]

  • Spastic Paraplegia - Precocious Puberty

    Anaemia and thrombocytopenia responded to treatment with prednisolone. Parents and siblings were screened for haemolysis and thrombocytopenia and found to be normal.[documents.tips] , see Kawasaki disease acute generalised pustular psoriasis, see generalized pustular psoriasis acute infectious polyneuritis, see Guillain-Barré syndrome acute inflammatory[mygenomics.com] Laboratory evaluation shows increased alpha-interferon ( IFNA1 ) activity with upregulation of interferon signaling and interferon-stimulated gene expression.[mendelian.co]

  • Interferon Beta-1a

    At admission, there was elevation of transaminases, anemia (hemoglobin 8.9 g/dL), thrombocytopenia (platelet 135,000/mm3), and hypofibrinogenemia (fibrinogen 1.26 g/L).[ncbi.nlm.nih.gov] Abstract The authors recruited 19 nonambulant patients with Guillain-Barré syndrome into a pilot, double-blind, randomized, placebo-controlled safety trial of interferon beta[n.neurology.org] In addition, interferon beta may bind to a distinct receptor that does not interact with interferon alpha.[iqb.es]

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