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5,573 Possible Causes for Alpha Interferon Activity Increased, Hypertrophic Osteoarthropathy, Thrombocytopenia

  • HIV Infection

    As part of the work up for thrombocytopenia, a rapid HIV antibody based assay was done and was negative.[ncbi.nlm.nih.gov] […] are not generally increased, although expression of IL-1, IL-2, IL-6, IL-12, and interferon-gamma may be elevated.(112) With administration of antiretroviral therapies, these[hivinsite.ucsf.edu] Laboratory analyses of blood samples may reveal anemia, leukopenia, and/or thrombocytopenia. Stage 4.[symptoma.com]

  • Recurrent Small-Cell Carcinoma of the Lung

    DLTs consisted of grade 2/3 neutropenia and grade 2 thrombocytopenia precluding treatment on day 15 of the first cycle or on day 1 of the second cycle.[ncbi.nlm.nih.gov] I.v. topotecan was associated with significantly higher toxicities (grade 4 thrombocytopenia and grade 3/4 anemia) and greater improvement in patient-reported symptoms compared[ncbi.nlm.nih.gov] Grade 3/4 adverse events ( 5% incidence) included anemia, thrombocytopenia, neutropenia/leukopenia, diarrhea, fatigue, dehydration, and hypokalemia for topotecan; and thrombocytopenia[ncbi.nlm.nih.gov]

    Missing: Alpha Interferon Activity Increased
  • Chronic Active Hepatitis

    Onset was signalled by an abrupt and dramatic thrombocytopenia, which was also the only laboratory parameter able to monitor treatment and progression of the disease.[ncbi.nlm.nih.gov] CONCLUSIONS: alpha-interferon therapy for patients with chronic active hepatitis B is cost effective. alpha-Interferon is more cost effective in toddlers than adults because[ncbi.nlm.nih.gov] Non-A, non-B viral hepatitis may cause many different hematologic abnormalities, such as transient anemia, granulocytopenia, thrombocytopenia, atypical lymphcytosis, or aplastic[ncbi.nlm.nih.gov]

  • Portal Cirrhosis

    Of the 12 patients with impaired aggregation, 6 had elevated levels of fibrinogen-fibrin degradation products (FDPs), 11 had thrombocytopenia, 10 had shortened euglobulin[ncbi.nlm.nih.gov] Abstract A recent paper by Vogl and Goldfischer (1) outlines the development of our ideas of hypertrophic osteoarthropathy.[annals.org] FDA approves lusutrombopag for thrombocytopenia in adults with chronic liver disease. Available at . July 31, 2018; Accessed: July 31, 2018.[medscape.com]

    Missing: Alpha Interferon Activity Increased
  • Paraneoplastic Syndrome

    Nasopharyngeal cancer (NPC) presenting with thrombocytopenia is rare. This report details 2 cases of NPC with grade III thrombocytopenia as a paraneoplastic syndrome.[ncbi.nlm.nih.gov] Von Willebrand factor antigen in hypertrophic osteoarthropathy. J. Rheumatol. 19, 765–767 (1992). 21. Silveri, E. et al.[nature.com] Thrombocytopenia may also be caused by autoantibodies; the causes of thrombocytosis are still unknown Marantic endocarditis is typical of mucous adenocarcinomas of lung,[emedicine.medscape.com]

    Missing: Alpha Interferon Activity Increased
  • Waters-West Syndrome

    The most common cause of thrombocytopenia during pregnancy is gestational thrombocytopenia, which is a mild thrombocytopenia with platelet levels remaining above 70,000/µL[emedicine.medscape.com] […] essential ( PNMT) Hypertension, essential ( AGTR1) Hypertension, essential ( PTGIS) Hyperthyroidism, familial gestational ( TSHR) Hyperthyroidism, nonautoimmune ( TSHR) Hypertrophic[en.praenatal-medizin.de] Laboratory evaluation shows increased alpha-interferon ( IFNA1 ) activity with upregulation of interferon signaling and interferon-stimulated gene expression.[mendelian.co]

  • Infectious Mononucleosis

    They include Granulocytopenia Thrombocytopenia Hemolytic anemia Transient mild granulocytopenia or thrombocytopenia occurs in about 50% of patients; severe cases, associated[merck.com] Th1 lineage mostly produce type 2 interleukin (IL-2), interferon-gamma (INF-γ) and tumor necrosis factor-alpha (TNF-α).[omicsonline.org] Corticosteroids may have a role in hastening resolution of some complications, especially upper airway obstruction and possibly immune-mediated anemia and thrombocytopenia[oadoi.org]

    Missing: Hypertrophic Osteoarthropathy
  • Macronodular Cirrhosis

    PHYSICAL FINDINGS & CLINICAL PRESENTATION SKIN: Jaundice, palmar erythema (alcohol abuse), spider angiomata, ecchymosis (thrombocytopenia or coagulation factor deficiency)[encyclopedia.lubopitko-bg.com] Nail changes: Clubbing, hypertrophic osteoarthropathy, and the Dupuytren contracture are seen.[ncbi.nlm.nih.gov] It is not specific for cirrhosis and can therefore be due to a number of conditions [18] Hypertrophic osteoarthropathy.[en.wikipedia.org]

    Missing: Alpha Interferon Activity Increased
  • Primary Myelofibrosis

    Six weeks later, he developed grade 4 thrombocytopenia and grade 3 anemia.[ncbi.nlm.nih.gov] Osteosclerosis, hypertrophic osteoarthropathy and periostitis: may cause severe joint and bone pain.[patient.info] osteoarthropathy, 345 gray platelet syndrome, 346 systemic lupus erythematosus, 239–242 polyarteritis nodosa, 245 hypereosinophilic syndrome, 347,348 kala azar, 349 primary[patient-help.com]

    Missing: Alpha Interferon Activity Increased
  • Primary Biliary Cirrhosis

    We herein report a rare case of IgG4-RD overlapping PBC complicated with autoimmune thrombocytopenia.[ncbi.nlm.nih.gov] A 54-year-old woman suffering from pruritus for five years was diagnosed to have Graves' disease and immune thrombocytopenia (ITP) associated with primary biliary cirrhosis[ncbi.nlm.nih.gov] Initial laboratory investigations revealed liver dysfunction, anemia and thrombocytopenia. Anti-nuclear (ANA) and antimitochondrial M2 (AMA M2) antibodies were positive.[ncbi.nlm.nih.gov]

    Missing: Alpha Interferon Activity Increased

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