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13 Possible Causes for Alpha Interferon Activity Increased, Hypoalbuminemia, Thrombocytopenia

  • Systemic Lupus Erythematosus

    Laboratory findings on admission revealed proteinuria, microscopic hematuria, anemia, leukopenia, hypoalbuminemia, hypocomplementemia, and slightly elevated levels of serum[ncbi.nlm.nih.gov] Background While thrombopoeitin (TPO) agonists that act to simulate platelet production have been approved for use in steroid-refractory chronic immune thrombocytopenia purpura[ncbi.nlm.nih.gov] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.com]

  • Alcoholic Hepatitis

    A blood test showed leukophilia, mild hypoalbuminemia, hyperbilirubinemia, hepatobiliary injury and coagulopathy.[ncbi.nlm.nih.gov] These findings suggest that PAIgG may have been involved in the development of thrombocytopenia in this patient.[ncbi.nlm.nih.gov] We analyzed clinical, biological, virological and histological features in two cases where alpha-interferon treatment for HCV-related hepatitis led to a marked increase in[ncbi.nlm.nih.gov]

  • Lupus Erythematosus

    Poor prognosis has been associated with high serum creatinine levels, hypertension, nephrotic syndrome, anemia, hypoalbuminemia, hypocomplementemia, antiphospholipid antibodies[lecturio.com] […] autoimmune thrombocytopenia).[merckmanuals.com] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com]

  • Waters-West Syndrome

    Metabolic acidosis Feeding difficulties in infancy Abnormality of the liver Aminoaciduria Polyneuropathy Aciduria Cholestasis Vomiting External ophthalmoplegia Hyponatremia Hypoalbuminemia[mendelian.co] The most common cause of thrombocytopenia during pregnancy is gestational thrombocytopenia, which is a mild thrombocytopenia with platelet levels remaining above 70,000/µL[emedicine.medscape.com] P1S2 Xp22.2 Mental retardation, X-linked syndromic 5 304340 A P3B1 5q14.1 Hermansky-Pudlak syndrome 2 608233 A PTX 9p21.1 Ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia[institutobernabeu.com]

  • Familial Hemophagocytic Lymphohistiocytosis

    Preterm male twins (31(4/7) wk) with NIHF and hepatosplenomegaly gradually developed pancytopenia, hyperferritinemia, hyponatremia, hypoalbuminemia, and elevated alanine aminotransferase[ncbi.nlm.nih.gov] Other significant findings include hepatosplenomegaly, progressive anemia, leukopenia, thrombocytopenia, hyperlipidemia and hypofibrinogenemia.[ncbi.nlm.nih.gov] […] expression of tumor necrosis factor-alpha and interferon-gamma, leading to increased macrophage activation.[healio.com]

  • Chronic Active Hepatitis

    Seropositive results for antinuclear antibodies (ANAs), smooth-muscle antibodies (SMAs), or liver-kidney microsomal type 1 (LKM-1) or anti–liver cytosol 1 (anti-LC1) antibodies Hypoalbuminemia[emedicine.medscape.com] Onset was signalled by an abrupt and dramatic thrombocytopenia, which was also the only laboratory parameter able to monitor treatment and progression of the disease.[ncbi.nlm.nih.gov] CONCLUSIONS: alpha-interferon therapy for patients with chronic active hepatitis B is cost effective. alpha-Interferon is more cost effective in toddlers than adults because[ncbi.nlm.nih.gov]

  • Malignant Angioendotheliomatosis

    In addition, this was sug- gested in our patient by the presence of anasarca without hypoalbuminemia.[myslide.es] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com] thrombocytopenia).[merckmanuals.com]

  • Renal Cell Carcinoma

    Most paraneoplastic signs and symptoms correlated with poor survival, although on multivariate analysis hypoalbuminemia, weight loss, anorexia and malaise predicted shorter[ncbi.nlm.nih.gov] Grade 3 or 4 events were for hand-foot syndrome 16%, thrombocytopenia 16% and stomatitis 10% ( 3 ). 3.1.[intjcancermanag.com] Beta-D-glucans may promote dendritic cell (DC) maturation; increase interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha) and immunoglobulin levels; and may[cancer.gov]

  • Myocarditis

    No change in standard management, though hypoalbuminemia may complicate efforts at diuresis. C. Systolic and Diastolic Heart Failure.[cancertherapyadvisor.com] Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral infectious disease with high mortality.[ncbi.nlm.nih.gov] The possible modes of action include enhancing natural killer cell activity, inducing production of alpha‐ and gamma‐interferon, improving cardiac microcirculation, and activity[doi.org]

  • Mycobacterium Avium Complex

    He subsequently developed noninfectious diarrhea, Hypoalbuminemia, recurrentpleural effusions, ascites, and Pneumocystis jiroveci pneumonia (PJP).[ncbi.nlm.nih.gov] Both leukocytopenia and thrombocytopenia had been noted in the patient's 19-year-old younger brother, who had been living in the same home 5 years earlier, and for whom a[ncbi.nlm.nih.gov] Individuals with localized pulmonary MAC infections showed increased activation of monocytes and enhanced monocyte and T-cell tumor necrosis factor alpha (TNF-alpha) production[ncbi.nlm.nih.gov]

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