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26 Possible Causes for Alpha Interferon Activity Increased, Jaundice, Thrombocytopenia

  • Infectious Mononucleosis

    We report a case of infectious mononucleosis in a 72-year old jaundiced gentleman with ferritin level of 2438 that normalised on clinical improvement.[ncbi.nlm.nih.gov] They include Granulocytopenia Thrombocytopenia Hemolytic anemia Transient mild granulocytopenia or thrombocytopenia occurs in about 50% of patients; severe cases, associated[merck.com] Th1 lineage mostly produce type 2 interleukin (IL-2), interferon-gamma (INF-γ) and tumor necrosis factor-alpha (TNF-α).[omicsonline.org]

  • Waters-West Syndrome

    jaundice (yellowing) and splenomegaly (enlargement of the spleen).[medicinenet.com] The most common cause of thrombocytopenia during pregnancy is gestational thrombocytopenia, which is a mild thrombocytopenia with platelet levels remaining above 70,000/µL[emedicine.medscape.com] Laboratory evaluation shows increased alpha-interferon ( IFNA1 ) activity with upregulation of interferon signaling and interferon-stimulated gene expression.[mendelian.co]

  • Alcoholic Hepatitis

    Slight clouding of consciousness, fever, and jaundice were evident on his admission to our hospital.[ncbi.nlm.nih.gov] These findings suggest that PAIgG may have been involved in the development of thrombocytopenia in this patient.[ncbi.nlm.nih.gov] We analyzed clinical, biological, virological and histological features in two cases where alpha-interferon treatment for HCV-related hepatitis led to a marked increase in[ncbi.nlm.nih.gov]

  • Chronic Active Hepatitis

    In a patient with chronic hepatitis who has already suffered relapses a search for a second cause of jaundice is not usually necessary.[ncbi.nlm.nih.gov] Onset was signalled by an abrupt and dramatic thrombocytopenia, which was also the only laboratory parameter able to monitor treatment and progression of the disease.[ncbi.nlm.nih.gov] CONCLUSIONS: alpha-interferon therapy for patients with chronic active hepatitis B is cost effective. alpha-Interferon is more cost effective in toddlers than adults because[ncbi.nlm.nih.gov]

  • Lupus Erythematosus

    […] stoppage or reduced flow of bile from the liver (cholestasis), inflammation of the liver (hepatitis), and yellowing of the skin, mucous membranes, and whites of the eyes (jaundice[rarediseases.org] […] autoimmune thrombocytopenia).[merckmanuals.com] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com]

  • Systemic Lupus Erythematosus

    The clinical presentation of PSC can vary; some patients are asymptomatic, whereas others show fatigue, jaundice, or pruritus [ 42 , 43 ].[omicsonline.org] Background While thrombopoeitin (TPO) agonists that act to simulate platelet production have been approved for use in steroid-refractory chronic immune thrombocytopenia purpura[ncbi.nlm.nih.gov] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.com]

  • Chronic Active Hepatitis B

    The symptoms of liver cancer include weight loss, loss of appetite, nausea and vomiting, and jaundice.[news-medical.net] Diseases commonly seen with autoimmune hepatitis include hemolytic anemia, immune thrombocytopenia, type 1 diabetes mellitus, thyroiditis, celiac sprue, ulcerative colitis[clinicaladvisor.com] CONCLUSIONS: alpha-interferon therapy for patients with chronic active hepatitis B is cost effective. alpha-Interferon is more cost effective in toddlers than adults because[ncbi.nlm.nih.gov]

  • HIV Infection

    […] dysfunction, and a bleeding tendency (particularly in people with hemophilia) Amprenavir (APV) Rash Atazanavir (ATV) Rash and yellowing of the skin and whites of the eyes (jaundice[merckmanuals.com] As part of the work up for thrombocytopenia, a rapid HIV antibody based assay was done and was negative.[ncbi.nlm.nih.gov] […] are not generally increased, although expression of IL-1, IL-2, IL-6, IL-12, and interferon-gamma may be elevated.(112) With administration of antiretroviral therapies, these[hivinsite.ucsf.edu]

  • Drug-Induced Lupus Erythematosus

    Minocycline oxytetracycline tetracycline Liver dysfunction: Raised liver enzymes, jaundice, liver dysfunction, hepatitis, liver failure.[doi.org] In conclusion, physicians should be alert to the possibility of DILE in patients presenting with thrombocytopenia under a capecitabine and bevacizumab chemotherapy regimen[ncbi.nlm.nih.gov] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.com]

  • Familial Hemophagocytic Lymphohistiocytosis

    […] oxygen Thrombocytopenia : low count of platelets that prevent bleeding Enlarged liver and/or spleen Abdominal distension, abdominal pain Weight loss, failure to thrive Rash Jaundice[danafarberbostonchildrens.org] Other significant findings include hepatosplenomegaly, progressive anemia, leukopenia, thrombocytopenia, hyperlipidemia and hypofibrinogenemia.[ncbi.nlm.nih.gov] […] expression of tumor necrosis factor-alpha and interferon-gamma, leading to increased macrophage activation.[healio.com]

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