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24 Possible Causes for Alpha Interferon Activity Increased, Leukocytosis, Thrombocytopenia

  • Infectious Mononucleosis

    They include Granulocytopenia Thrombocytopenia Hemolytic anemia Transient mild granulocytopenia or thrombocytopenia occurs in about 50% of patients; severe cases, associated[merck.com] Th1 lineage mostly produce type 2 interleukin (IL-2), interferon-gamma (INF-γ) and tumor necrosis factor-alpha (TNF-α).[omicsonline.org] Sprunt, Frank Alexander Evans (1889-1956): Mononuclear leukocytosis in reaction to acute infection (infectious mononucleosis).[whonamedit.com]

  • Systemic Lupus Erythematosus

    Background While thrombopoeitin (TPO) agonists that act to simulate platelet production have been approved for use in steroid-refractory chronic immune thrombocytopenia purpura[ncbi.nlm.nih.gov] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.com] Erythematosus Differential diagnosis Distinguishing features Diagnostic approach Adult-onset Still disease Arthralgia, fever, lymphadenopathy, splenomegaly Tests for elevated ESR, leukocytosis[aafp.org]

  • Alcoholic Hepatitis

    These findings suggest that PAIgG may have been involved in the development of thrombocytopenia in this patient.[ncbi.nlm.nih.gov] We analyzed clinical, biological, virological and histological features in two cases where alpha-interferon treatment for HCV-related hepatitis led to a marked increase in[ncbi.nlm.nih.gov] Although a leukocytosis of 15,000-18,000 cells/mm(3) is frequently seen in AH, LRs are rare in this context.[ncbi.nlm.nih.gov]

  • Lupus Erythematosus

    […] autoimmune thrombocytopenia).[merckmanuals.com] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com] Erythematosus Differential diagnosis Distinguishing features Diagnostic approach Adult-onset Still disease Arthralgia, fever, lymphadenopathy, splenomegaly Tests for elevated ESR, leukocytosis[aafp.org]

  • Renal Cell Carcinoma

    Grade 3 or 4 events were for hand-foot syndrome 16%, thrombocytopenia 16% and stomatitis 10% ( 3 ). 3.1.[intjcancermanag.com] Her admission analysis reported haemoglobin 6.5 g/dl, thrombocytosis 797 10 3 /mm 3, leukocytosis 14.7 10 3 /mm 3 with neutrophilia of 12.9 10 3 /mm 3 and elevated C reactive[elsevier.es] Beta-D-glucans may promote dendritic cell (DC) maturation; increase interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha) and immunoglobulin levels; and may[cancer.gov]

  • Childhood Dermatomyositis

    Lymphoma, nausea, vomiting, hepatotoxicity, leukopenia, oral ulcers, thrombocytopenia Screen patients for thiopurine methyltransferase deficiency before therapy (0.3 to 11[aafp.org] Activation of dendritic cells with upregulation of genes induced by type-1 interferon (alpha) in muscle and peripheral blood seems to be central to disease pathogenesis.[ncbi.nlm.nih.gov] Hematologic abnormalities, such as anemia, granulocytopenia, and thrombocytopenia, under 107.00. i.[ssa.gov]

  • Waters-West Syndrome

    The most common cause of thrombocytopenia during pregnancy is gestational thrombocytopenia, which is a mild thrombocytopenia with platelet levels remaining above 70,000/µL[emedicine.medscape.com] Laboratory evaluation shows increased alpha-interferon ( IFNA1 ) activity with upregulation of interferon signaling and interferon-stimulated gene expression.[mendelian.co] DIAGNOSIS / PATHOLOGY: Leukocytosis : Sustained leukocytosis 20,000 shows left-shift with myelocyte bulge (too many myelocytes in peripheral blood).[kumc.edu]

  • Drug-Induced Lupus Erythematosus

    In conclusion, physicians should be alert to the possibility of DILE in patients presenting with thrombocytopenia under a capecitabine and bevacizumab chemotherapy regimen[ncbi.nlm.nih.gov] 昆虫アレルギー interstitial nephritis間質性腎炎 interstitial pneumonia間質性肺炎 intractable asthma難治性喘息 intracutaneous reaction皮内反応 j jerk fingerばね指、弾発指 l LE factorLE因子 LE phenomenonLE現象 leukocytosis[tokyo-med.ac.jp] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.com]

  • Familial Hemophagocytic Lymphohistiocytosis

    Other significant findings include hepatosplenomegaly, progressive anemia, leukopenia, thrombocytopenia, hyperlipidemia and hypofibrinogenemia.[ncbi.nlm.nih.gov] […] expression of tumor necrosis factor-alpha and interferon-gamma, leading to increased macrophage activation.[healio.com] Leukocytosis was detected with circulating "atypical" lymphoid cells.[ncbi.nlm.nih.gov]

  • Chronic Active Hepatitis

    Onset was signalled by an abrupt and dramatic thrombocytopenia, which was also the only laboratory parameter able to monitor treatment and progression of the disease.[ncbi.nlm.nih.gov] CONCLUSIONS: alpha-interferon therapy for patients with chronic active hepatitis B is cost effective. alpha-Interferon is more cost effective in toddlers than adults because[ncbi.nlm.nih.gov] Further confirmation of the diagnosis can then be made via laboratory data (ie, elevated C-reactive protein levels and/or leukocytosis) and abdominal imaging tests indicating[gastroenterologyandhepatology.net]

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