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34 Possible Causes for Alpha Interferon Activity Increased, Malaise

  • Infectious Mononucleosis

    Th1 lineage mostly produce type 2 interleukin (IL-2), interferon-gamma (INF-γ) and tumor necrosis factor-alpha (TNF-α).[omicsonline.org] A 16-year-old, previously healthy girl presents with a several-day history of fever, sore throat, and malaise. She appears very tired and has a temperature of 39 C.[oadoi.org] In EBV infection levels of abnormal circulating Th1 lymphocytes are increased, leading to activation of cell-mediated immunity.[omicsonline.org]

  • Chronic Fatigue Syndrome

    , increased interferon activity, cytokine levels, lymphocyte cell markers, or natural killer cells.[aafp.org] Post exertion malaise is one of the most debilitating aspects of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, yet the neurobiological consequences are largely unexplored[ncbi.nlm.nih.gov] Also, an association with symptoms of post-exertional malaise was demonstrated.[ncbi.nlm.nih.gov]

  • Renal Cell Carcinoma

    Beta-D-glucans may promote dendritic cell (DC) maturation; increase interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha) and immunoglobulin levels; and may[cancer.gov] Most paraneoplastic signs and symptoms correlated with poor survival, although on multivariate analysis hypoalbuminemia, weight loss, anorexia and malaise predicted shorter[ncbi.nlm.nih.gov] Conclusions: Cachexia, defined as hypoalbuminemia, weight loss, anorexia or malaise, predicts worse survival after controlling for well established indicators of prognosis[doi.org]

  • HIV Infection

    […] are not generally increased, although expression of IL-1, IL-2, IL-6, IL-12, and interferon-gamma may be elevated.(112) With administration of antiretroviral therapies, these[hivinsite.ucsf.edu] The patient presented with acute onset of fever, cough, hemoptysis and malaise.[ncbi.nlm.nih.gov] Hodinka Abstract A 15-year-old previously healthy male presented with fever, vomiting, diarrhea, malaise, and altered mental status.[pediatrics.aappublications.org]

  • Systemic Lupus Erythematosus

    The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.com] In addition, individuals also experience fever, fatigue, malaise, sensitivity to light and development of butterfly shaped rashes.[symptoma.com] Non-specific symptoms of fatigue, malaise, oral ulcers, arthralgia, photosensitive skin rashes, lymphadenopathy, pleuritic chest pains, headache, paraesthesiae, symptoms of[dx.doi.org]

  • Alcoholic Hepatitis

    We analyzed clinical, biological, virological and histological features in two cases where alpha-interferon treatment for HCV-related hepatitis led to a marked increase in[ncbi.nlm.nih.gov] […] circulation Bone Rib fractures on CXR Spinal osteoporosis (particularly in men) Generally, patients with fatty liver have few symptoms, however they may notice nausea and malaise[almostadoctor.co.uk] […] aminotransferase activities. alpha-interferon as treatment of HCV-related hepatitis seemed to exacerbate acute alcoholic hepatitis despite moderate alcohol consumption.[ncbi.nlm.nih.gov]

  • Chronic Active Hepatitis B

    CONCLUSIONS: alpha-interferon therapy for patients with chronic active hepatitis B is cost effective. alpha-Interferon is more cost effective in toddlers than adults because[ncbi.nlm.nih.gov] Transient side effects of malaise and influenza like symptoms occurred in all patients and resolved rapidly after treatment.[ncbi.nlm.nih.gov] Snapshot A 35-year-old presents to the emergency department due to abdominal pain and malaise. He also reports "yellow-ing" of his skin.[medbullets.com]

  • Viral Pneumonia

    Retrospective observational reports of combination treatment with ribavirin and pegylated interferon alpha have shown inconsistent results.[clinicaladvisor.com] Presentation Pearls Diagnosis Treatment Media Patient will present as a 45-year-old male with a one week history of hacking non-productive cough, low grade fever, malaise[smartypance.com] Clinical manifestations may include upper respiratory symptoms, conjunctivitis, and rhinitis in association with fever, nonproductive cough, and malaise.[visualdx.com]

  • Childhood Dermatomyositis

    Activation of dendritic cells with upregulation of genes induced by type-1 interferon (alpha) in muscle and peripheral blood seems to be central to disease pathogenesis.[ncbi.nlm.nih.gov] A 62-year-old woman presented to the emergency department with malaise, lethargy and proximal muscle weakness. She had a similar presentation in childhood.[ncbi.nlm.nih.gov] (known as heliotrope rash ) and/or knuckles and finger joints (called Gottren’s papules ); a rash may also occur on the elbows, knees and ankles muscle weakness fatigue malaise[childrenshospital.org]

  • Mycobacterium Avium Complex

    Individuals with localized pulmonary MAC infections showed increased activation of monocytes and enhanced monocyte and T-cell tumor necrosis factor alpha (TNF-alpha) production[ncbi.nlm.nih.gov] A 54-year-old man was admitted to our hospital because of intermittent high fever, general malaise, cough and body weight loss after he had been examined and treated at the[ncbi.nlm.nih.gov] They include fever, night sweats, anorexia and malaise, weight loss, chronic diarrhoea and non-specific abdominal pain, hepatomegaly and anaemia are common.[apps.who.int]

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