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22 Possible Causes for Alpha Interferon Activity Increased, Myocarditis, Thrombocytopenia

  • Infectious Mononucleosis

    Acute chest pain in myocarditis mimics acute coronary syndrome.[cfp.ca] They include Granulocytopenia Thrombocytopenia Hemolytic anemia Transient mild granulocytopenia or thrombocytopenia occurs in about 50% of patients; severe cases, associated[merck.com] Th1 lineage mostly produce type 2 interleukin (IL-2), interferon-gamma (INF-γ) and tumor necrosis factor-alpha (TNF-α).[omicsonline.org]

  • Systemic Lupus Erythematosus

    She was diagnosed with severe lupus myocarditis, and a renal biopsy also confirmed lupus nephritis.[ncbi.nlm.nih.gov] Background While thrombopoeitin (TPO) agonists that act to simulate platelet production have been approved for use in steroid-refractory chronic immune thrombocytopenia purpura[ncbi.nlm.nih.gov] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com]

  • Lupus Erythematosus

    […] lymphadenopathy weight loss multisystem symptoms Examination SKIN: skin and joint involvement common, oral and pharyngeal ulceration, alopcecia CARDIOVASCULAR: pericarditis 15%, myocarditis[lifeinthefastlane.com] […] autoimmune thrombocytopenia).[merckmanuals.com] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com]

  • Drug-Induced Lupus Erythematosus

    Possible Complications Infection Thrombocytopenia purpura -- bleeding near the skin surface, resulting from a low number of platelets in the blood Hemolytic anemia Myocarditis[lutheranhealthcare.org] In conclusion, physicians should be alert to the possibility of DILE in patients presenting with thrombocytopenia under a capecitabine and bevacizumab chemotherapy regimen[ncbi.nlm.nih.gov] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.com]

  • Myocarditis

    Mild cases of myocarditis seldom produce any symptoms.[symptoma.com] Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral infectious disease with high mortality.[ncbi.nlm.nih.gov] The possible modes of action include enhancing natural killer cell activity, inducing production of alpha‐ and gamma‐interferon, improving cardiac microcirculation, and activity[doi.org]

  • HIV Infection

    Other HIV-associated cardiac complications (i.e., cardiomyopathy, myocarditis, and pericarditis) are still reported, although their incidence has decreased as combination[aafp.org] As part of the work up for thrombocytopenia, a rapid HIV antibody based assay was done and was negative.[ncbi.nlm.nih.gov] […] are not generally increased, although expression of IL-1, IL-2, IL-6, IL-12, and interferon-gamma may be elevated.(112) With administration of antiretroviral therapies, these[hivinsite.ucsf.edu]

  • Mycobacterium Avium Complex

    What causes myocarditis?[bhf.org.uk] Both leukocytopenia and thrombocytopenia had been noted in the patient's 19-year-old younger brother, who had been living in the same home 5 years earlier, and for whom a[ncbi.nlm.nih.gov] Individuals with localized pulmonary MAC infections showed increased activation of monocytes and enhanced monocyte and T-cell tumor necrosis factor alpha (TNF-alpha) production[ncbi.nlm.nih.gov]

  • Local Lupus Erythematosus

    […] lungs, brain, or intestines Destruction of red blood cells or anemia of long-term (chronic) disease Fluid around the heart (pericarditis), or inflammation of the heart ( myocarditis[medlineplus.gov] […] autoimmune thrombocytopenia).[merckmanuals.com] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com]

  • Idiopathic Recurrent Pericarditis

    The findings were indicative of lymphocytic myocarditis.[escardio.org] She had thrombocytopenia, a leukocyte count within the normal range, and a high C-reactive protein level.[wwwnc.cdc.gov] Yan B, Ye S, Chen G, Kuang M, Shen N, Chen S: Dysfunctional CD4 ,CD25 regulatory T cells in untreated active systemic lupus erythematosus secondary to interferon-alpha-producing[karger.com]

  • Childhood Dermatomyositis

    Although primarily a disease of muscle and skin, juvenile dermatomyositis has a clear association with myocarditis, vasculitis, calcinosis and interstitial lung disease. .[mhmedical.com] Lymphoma, nausea, vomiting, hepatotoxicity, leukopenia, oral ulcers, thrombocytopenia Screen patients for thiopurine methyltransferase deficiency before therapy (0.3 to 11[aafp.org] Activation of dendritic cells with upregulation of genes induced by type-1 interferon (alpha) in muscle and peripheral blood seems to be central to disease pathogenesis.[ncbi.nlm.nih.gov]

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