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365 Possible Causes for Alpha Interferon Activity Increased, Partial Thromboplastin Time Increased

  • Systemic Lupus Erythematosus

    Although LAC is prothrombotic, the clinician must be aware that it can falsely prolong activated partial thromboplastin time (aPTT), and conversely any increased aPTT result[journals.lww.com] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.com] Reports pointing to important roles of interferon-alpha, transcription factors, and signaling variations also point to a central role for neutrophils. [21] Genetics There[emedicine.com]

  • Alcoholic Hepatitis

    We analyzed clinical, biological, virological and histological features in two cases where alpha-interferon treatment for HCV-related hepatitis led to a marked increase in[ncbi.nlm.nih.gov] […] aminotransferase activities. alpha-interferon as treatment of HCV-related hepatitis seemed to exacerbate acute alcoholic hepatitis despite moderate alcohol consumption.[ncbi.nlm.nih.gov]

  • Coagulation Abnormalities

    It is likely that only with the increasing requests for prothrombin time and activated partial thromboplastin time are abnormal results noted.[ncbi.nlm.nih.gov] Higher incidence of prematurity, hyperbilirubinaemia and significant prolongation in partial thromboplastin time with kaolin (PTTK) and thrombin time (TT) values were observed[ncbi.nlm.nih.gov] thromboplastin time and decrease in prothrombin activity.[ncbi.nlm.nih.gov]

    Missing: Alpha Interferon Activity Increased
  • Disseminated Intravascular Coagulation

    Clotting factors Pro Thrombin (PT) and Partial Thromboplastin Time (PTT) increases.[en.wikivet.net] Increased activated partial thromboplastin time (APTT) – this measures the time it takes for clots to form by various pathways in the body.[myvmc.com] , activated partial thromboplastin time, and thrombin time, due to consumption of clotting factors and inhibition of their function.[epilepsy.com]

    Missing: Alpha Interferon Activity Increased
  • Portal Cirrhosis

    Laennec's cirrhosis, also known as portal cirrhosis, alcoholic cirrhosis, fatty cirrhosis, or atrophic cirrhosis, [1] is named after René Laennec, [2] a French physician and the inventor of the stethoscope. It is a disease of the liver in which the normal lobular architecture is lost, with fibrosis (scarring) and later[…][en.wikipedia.org]

    Missing: Alpha Interferon Activity Increased
  • Hemophilia

    Plasma concentrations of emicizumab increased in a dose-dependent manner. Activated partial-thromboplastin times remained short throughout the study.[doi.org] During treatment, the activated partial-thromboplastin time remained short, and factor XIa–triggered thrombin generation was detected at each assessment in all three cohorts[doi.org] In cohort 3, in which the initial dose and subsequent doses were the same, the mean trough level gradually increased to 87.9 20.0 μg per milliliter by week 12 but did not[doi.org]

    Missing: Alpha Interferon Activity Increased
  • Liver Failure

    partial thromboplastin time (PTT) become prolonged when plasma coagulation components are diluted to less than 30%, and abnormal bleeding occurs when they are less than 17%[emedicine.medscape.com] One unit of FFP increases the coagulation factor by 5%; 2 units increase it by 10%. An FFP infusion of 15 mL/kg of body weight or 4 units will correct the deficiency.[emedicine.medscape.com] The exception is when an invasive procedure is planned or in the presence of profound coagulopathy (international normalized ratio [INR] 7). [41] Prothrombin time (PT) and[emedicine.medscape.com]

    Missing: Alpha Interferon Activity Increased
  • Macronodular Cirrhosis

    BACKGROUND/AIMS: Incomplete septal cirrhosis (ISC) is a form of macronodular cirrhosis characterized by slender, incomplete septa that demarcate inconspicuous nodules. Its clinical features have not been investigated in a large series. The aims of this study were to review the clinical symptoms and evolution of ISC in[…][ncbi.nlm.nih.gov]

    Missing: Alpha Interferon Activity Increased
  • Isoniazid Hepatitis

    Abstract On request of local health officials, the authors investigated isoniazid (INH) hepatitis morbidity and mortality among patients attending an Hispanic prenatal clinic. Among 3,681 women treated with INH during and after pregnancy to prevent tuberculosis (TB), 5 developed INH hepatitis, and 2 of the 5 women[…][ncbi.nlm.nih.gov]

    Missing: Alpha Interferon Activity Increased
  • Acute Myelocytic Leukemia

    The World Health Organization (WHO) classification of lympho-hematopoietic neoplasms is increasingly based on genetic criteria. Here, we focus on changes that, as compared to the 2001 edition, were introduced into the 2008 WHO classification of acute myeloid leukemia (AML) and related precursor neoplasms. The[…][ncbi.nlm.nih.gov]

    Missing: Alpha Interferon Activity Increased

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