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19 Possible Causes for Alpha Slowing - 4-6 Hz Spikes - Myoclonus on Photic Stimulation Stage 2, Genetic Heterogeneity

  • Benign Adult Familial Myoclonic Epilepsy

    Abstract Benign adult familial myoclonic epilepsy (BAFME) has been mapped to chromosome 8q24; however, genetic heterogeneity has been recently suggested.[ncbi.nlm.nih.gov] This observation would confirm that BAFME is a worldwide, genetically heterogeneous condition, probably with Japanese families linked to 8q24 and European families to 2p11.1[ncbi.nlm.nih.gov] ", keywords "BAFME, Cortical tremor, Genetics, Myoclonic epilepsy", author "Pasquale Striano and Rosanna Chifari and Salvatore Striano and {De Fusco}, Maurizio and Maurizio[moh-it.pure.elsevier.com]

  • Alzheimer Disease

    Jean-Charles Lambert and Philippe Amouyel, Genetic heterogeneity of Alzheimer's disease: Complexity and advances, Psychoneuroendocrinology, 32, (S62), (2007).[dx.doi.org] Whether this will hold true for a genetically complex and heterogeneous disease such as AD is not known, although early reports are encouraging.[ncbi.nlm.nih.gov] Nilüfer Ertekin-Taner, Genetics of Alzheimer's Disease: A Centennial Review, Neurologic Clinics, 10.1016/j.ncl.2007.03.009, 25, 3, (611-667), (2007).[dx.doi.org]

  • Juvenile Myoclonic Epilepsy

    BACKGROUND: Juvenile myoclonic epilepsy (JME), is an early-onset inherited generalized epilepsy which displays genetic heterogeneity, with at least 10 known loci.[ncbi.nlm.nih.gov] Abstract Juvenile myoclonic epilepsy (JME) is a clinically and genetically heterogenous, generalized epilepsy syndrome usually starting in adolescence.[ncbi.nlm.nih.gov] heterogeneity is suspected.[pmj.bmj.com]

  • Idiopathic Generalized Epilepsy

    The lack of significant association evidence of single variants with disease in this two-stage approach emphasizes the high genetic heterogeneity of epilepsy disorders, suggests[ncbi.nlm.nih.gov] Molecular genetic analyses have led to important breakthroughs in the identification of candidate genes and loci; genetic heterogeneity is common.[epilepsy.com] Genetic Heterogeneity of Idiopathic Generalized Epilepsy EIG1 has been mapped to chromosome 8q24.[diseaseinfosearch.org]

  • Epilepsy

    Progressive myoclonic epilepsies (PME) are a clinically and genetically heterogeneous group of rare diseases characterized by myoclonic seizures, tonic-clonic seizures, and[ncbi.nlm.nih.gov] This observation along with our previous findings of hot water genetic loci at 10q21.3-q22.3 (OMIM: 613339) and 4q24-q28 (OMIM: 613340), indicates unanticipated genetic heterogeneity[ncbi.nlm.nih.gov] Due to clinical and genetic heterogeneity of PMEs, it is difficult to decide which genes are affected.[ncbi.nlm.nih.gov]

  • Stroke

    genetic model (GG   GT vs TT).[ncbi.nlm.nih.gov] Heterogeneity was assessed by using Q test and I test. Publication bias was evaluated by using Egger method.[ncbi.nlm.nih.gov] Four gene models were analyzed including, allele genetic model (G vs T), additive genetic model (GG vs TT, GT vs TT), recessive genetic model (GG vs GT   TT), and dominant[ncbi.nlm.nih.gov]

  • Myoclonic-Astatic Epilepsy

    […] influences and clues for genetic heterogeneity, and discuss strategies that may be helpful in elucidating the etiology of MAE in light of current genetic techniques.[ncbi.nlm.nih.gov] Doose Syndrome is likely to be genetically heterogeneous and – in contrast to Dravet Syndrome – caused by various different genes.[epilepsygenetics.net] Neuronal ceroid lipofuscinoses (NCLFs) include clinically and genetically heterogeneous storage disorders, which can be found in very young patients, but also in adults.[epilepsyontario.org]

  • Generalized Clonic or Tonic-Clonic Seizures

    Genetic Heterogeneity of Progressive Myoclonic EpilepsyProgressive myoclonic epilepsy refers to a clinically and genetically heterogeneous group of neurodegenerative disorders[mendelian.co] Genetic Heterogeneity of Mosaic Variegated Aneuploidy SyndromeSee also MVA2 ( OMIM ), caused by mutation in the CEP57 gene ( OMIM ) on chromosome 11q21, and MVA3 ( OMIM ),[mendelian.co] […] description and a discussion of genetic heterogeneity of early infantile epileptic encephalopathy, see EIEE1 ( OMIM ).[mendelian.co]

  • Unverricht-Lundborg Syndrome

    Disease Characteristics Unverricht-Lundborg disease (EPM1; OMIM 254800) is the most common of the rare genetically heterogeneous progressive myoclonic epilepsies.[epilepsy.com] This emphasizes the potential confounding effect of genetic heterogeneity in attempts to localize genes by homozygosity mapping in inbred populations, as previously discussed[academic.oup.com] .  Genetically heterogenous. 21.  Inclusions are also present in the peripheral blood lymphocytes and their morphology correlate with the clinical course and genetic analysis[slideshare.net]

  • West Syndrome

    West syndrome is genetically heterogeneous, and its genetic causes have not been fully elucidated.[ncbi.nlm.nih.gov] This disorder is genetically heterogeneous, with up to a fifth of cases resulting from mutations in the CDKL5 gene.[genedx.com] Identification of genetic associations of IS, a rapidly developing area, suggests IS is a genetically heterogeneous condition involving abnormalities in key developmental[bmcpediatr.biomedcentral.com]

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