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14 Possible Causes for Alternating Parakeratosis and Orthokeratosis

  • Actinic Keratosis

    A "flag sign" is often described, referring to alternating areas of orthokeratosis and parakeratosis.[en.wikipedia.org]

  • Pityriasis Rubra Pilaris

    Microscopically follicular plugging, in addition to checkerboard alternating orthokeratosis/parakeratosis, may serve as clues to PRP diagnosis.[ncbi.nlm.nih.gov] Skin biopsy showed alternating orthokeratosis, parakeratosis, acanthosis, broad and short rete ridges, and preserved granular layer in keeping with PRP [Figure 4].[tjmrjournal.org] Histologically, PRP is characterized by psoriasiform acanthosis with alternating orthokeratosis and parakeratosis and rarely small acantholytic foci.[ncbi.nlm.nih.gov]

  • Pemphigus Vulgaris

    Histologically, PRP is characterized by psoriasiform acanthosis with alternating orthokeratosis and parakeratosis and rarely small acantholytic foci.[ncbi.nlm.nih.gov]

  • Acid Ingestion

    […] with alternating layers of orthokeratosis and considerable superficial exfoliation; accompanying dermal changes included vasodilatation and mild perivascular inflammation[ncbi.nlm.nih.gov] Histopathology from a right arm shave biopsy revealed a mostly intact epidermis with subtle vacuolar alteration of the basal layer, scattered intraepidermal apoptotic keratinocytes, parakeratosis[ncbi.nlm.nih.gov]

  • Epidermal Nevus Syndrome

    Histologic examination of inflammatory linear verrucous epidermal nevus reveals a similar psoriasiform hyperplasia of the epidermis, alternating parakeratosis without a granular[dermaamin.com] […] layer, and orthokeratosis with a thickened granular layer.[dermaamin.com]

  • Phakomatosis Pigmentokeratotica

    Histologic examination of inflammatory linear verrucous epidermal nevus reveals a similar psoriasiform hyperplasia of the epidermis, alternating parakeratosis without a granular[dermaamin.com] […] layer, and orthokeratosis with a thickened granular layer.[dermaamin.com]

  • Tinea Capitis

    The stratum corneum may show compact orthokeratosis or sometimes the "sandwich sign": ortho- or parakeratosis alternating in layers with the normal basket-weave stratum corneum[dermpedia.org]

  • Tinea Capitis Profunda

    […] or parakeratosis alternating in layers with basket-weave stratum corneum. 4,5 Hyphae can often be seen in this area.[clinicaladvisor.com] […] overlapping each other, resembling shingles on a roof (imbrex is another word for shingle). 8 The sandwich sign is often present in tinea corporis and is distinguished by orthokeratosis[clinicaladvisor.com]

  • Bullous Erythroderma Ichthyosiformes

    Alternating vertical orthokeratosis and parakeratosis may be seen. There is focal acantholysis with dyskeratotic cells. Spongiotic changes may also be seen.[ijdpdd.com] The epidermal lining shows suprabasal clefts with many dyskeratotic cells (corps ronds). ( 400) Click here to view Grover's disease There is hyperkeratosis, acanthosis and parakeratosis[ijdpdd.com]

  • Boric Acid

    […] with alternating layers of orthokeratosis and considerable superficial exfoliation; accompanying dermal changes included vasodilatation and mild perivascular inflammation[ncbi.nlm.nih.gov] Histopathology from a right arm shave biopsy revealed a mostly intact epidermis with subtle vacuolar alteration of the basal layer, scattered intraepidermal apoptotic keratinocytes, parakeratosis[ncbi.nlm.nih.gov]

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