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91 Possible Causes for Ammonia Increased, Respiratory Alkalosis

  • Urea Cycle Disorder

    An increased level of ammonia in the bloodstream, or hyperammonemia, is a symptom associated with metabolic disorders referred to as inborn errors of metabolism.[ncbi.nlm.nih.gov] […] distress * Respiratory alkalosis * Increased blood ammonia level * Failure to thrive * Constant infant crying * Agitation * Hyperactive behavior * Self-injury * Screaming[checkorphan.org] Soon after, seizures, hypotonia (poor muscle tone, floppiness), respiratory distress (respiratory alkalosis), and coma may occur.[nucdf.org]

  • Propionic Acidemia

    OBJECTIVES: The objective of this study was to determine whether N-carbamylglutamate (NCG) reduces plasma levels of ammonia and glutamine and increases the rate of ureagenesis[ncbi.nlm.nih.gov] While hyperventilation may provoke respiratory alkalosis, most patients present with metabolic acidosis due to further metabolic disturbances.[symptoma.com] Alkalosis Urea cycle disorders Metabolic Profiles Organic and Amino Acid Disorders Metabolic Profiles Organic and Amino Acid Disorders Newborn screening is available dependent[vdocuments.mx]

  • Carbamoyl Phosphate Synthetase Deficiency

    They may rapidly progress to respiratory alkalosis as ammonia increases with cerebral edema, seizures, loss of reflexes, hypothermia, apnea, and coma.[clinicaladvisor.com] Neonatal onset results in clinical features that include irritability, vomiting, lethargy, seizures, neonatal hypotonia; respiratory alkalosis; hyperammonemia; coma, and death[icd9data.com] Biochemically, a highly elevated blood ammonia level was found together with an increased plasma level of the amino acids mainly involved in ammonia detoxication.[ncbi.nlm.nih.gov]

  • Psychogenic Hyperventilation

    Causes of Respiratory Alkalosis 1.[ld99.com] ammonia and glutamine, and hypoxemia from the formation of small intrapulmonary shunts (ie: hepatopulmonary syndrome) - increased respiratory drive Neurologic/Psychogenic[mdnxs.com] (metabolic acidosis and respiratory alkalosis).[anaesthesiamcq.com]

  • Hyperornithinemia-Hyperammonemia-Homocitrullinuria Syndrome

    Blood ammonia increased from high normal values to 975, 990, and 750 mumol/liter (normal less than 70) and urinary orotic acid from trace to 539, 494, and 1296 mumol/mmol[ncbi.nlm.nih.gov] The neonatal presentation usually begins a few days after birth with lethargy, somnolence, refusal to feed, vomiting, tachypnea with respiratory alkalosis, and/or seizures[orpha.net] Increased levels of ammonia, ornithine and homocitrulline were demonstrated in blood and cerebrospinal fluid.[ncbi.nlm.nih.gov]

  • Alcoholic Liver Disease

    alkalosis Hypomagnesemia Hypophosphatemia Hyponatremia Hypokalemia Back to Top Treatment The foundation of therapy for ALD is abstinence.[clevelandclinicmeded.com] The main factor involved in causing the encephalopathy is an increase in ammonia levels in the brain.[netdoctor.co.uk] Examples include: Hepatic encephalopathy: Increased ammonia levels due to the liver's inability to process and metabolize proteins in the diet can cause confusion, lethargy[medicinenet.com]

  • Acute Liver Failure

    These substances include false neurotransmitters, ammonia, increased gamma-aminobutyric acid receptor activity, and increased circulating levels of endogenous benzodiazepine-like[emedicine.com] Metabolic: Metabolic and respiratory alkalosis may occur early. If shock develops, metabolic acidosis can supervene.[merckmanuals.com] To eliminate the source of increased ammonia, you’ll likely administer lactulose, a cathartic that will increase bowel movements.[americannursetoday.com]

  • Reye Syndrome

    Signs of metabolic derangement include elevated serum amino acid levels, acid-base disturbances (usually with hyperventilation, mixed respiratory alkalosis–metabolic acidosis[merckmanuals.com] The coma deepens even further, seizures develop, respiratory failure occurs, the blood level of ammonia increases, and death generally ensues.[web.archive.org] An initial metabolic acidosis is associated with a compensatory respiratory alkalosis (1,3). The EEG shows diffuse arrhythmic delta activity (1).[hawaii.edu]

  • Acidosis

    The production of IMP results from an increased activity of the AMP deaminase reaction, which is activated by acidosis and produces IMP and ammonia (NH 4 ); AMP H « IMP NH[sportsci.org] […] patients who have respiratory alkalosis, the tidal volume and/or respiratory rate may need to be decreased.[slideshare.net] Renal ammonia genesis: Ammonium ions (NH4 ) are produced in the proximal tubule from glutamine metabolism.[acid-base.com]

  • Hyperammonemia Type 3

    As has been indicated above, the central nervous system is most sensitive to increased concentrations of ammonia.[symptoma.com] The presence of respiratory alkalosis in a sick, hyperammonemic neonate or infant is an indicator of an underlying urea cycle defect since it is an uncommon finding in an[newenglandconsortium.org] Ammonia levels may be factitiously increased if the tourniquet is too tight for a long period.[ebmconsult.com]

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