Amyloid Plaque: Causes & Reasons

Possible Causes for Amyloid Plaque

Zinc has actually been shown to reduce the toxic effect of the amyloid plaques by changing the amyloid proteins into a shape that is less harmful to the brain. [alzheimers.org.uk]

Immunisation of patients with Alzheimer's disease with full-length amyloid-beta peptide (Abeta(42)) can clear amyloid plaques from the brain. [ncbi.nlm.nih.gov]

It becomes overactive, it proliferates and it sometimes tries to wall off these amyloid plaques as if itâ€™s trying to protect [itself] from them. [dnalc.cshl.edu]

Kuru

Amyloid plaques, so characteristic of kuru, also did not figure in the similarity, for they had not yet been reported in scrapie. [ncbi.nlm.nih.gov]

Neuropathologically, kuru-affected brains were characterized by widespread degeneration of neurons, astroglial and microglial proliferation, and the presence of amyloid plaques [ncbi.nlm.nih.gov]

The clinical phenotype of such cases should be similar to that of homozygous cases, but may have less (or at least less readily identified) amyloid plaque formation. [ncbi.nlm.nih.gov]

Creutzfeldt Jakob Disease

in addition to disease duration, in generating white matter PrP-amyloid plaques in p-CJDMM1. [ncbi.nlm.nih.gov]

KEYWORDS: Creutzfeldt-Jakob disease; MV2K+C; cerebellum; single unglycosylated band; small amyloid plaques [ncbi.nlm.nih.gov]

Microscopically visible kuru-type amyloid plaques were found in 5% of patients with Creutzfeldt-Jakob disease, 75% of those with kuru, and 100% of those with Gerstmann-Sträussler-Scheinker [ncbi.nlm.nih.gov]

Systemic Amyloidosis

Amyloid 13, 20–23 (2006). 60. Burns, M. P. et al. Co-localization of cholesterol, apolipoprotein E and fibrillar Aβ in amyloid plaques. Mol. Brain. [doi.org]

Amyloid 13, 20–23 (2006). [ PubMed ] [ Google Scholar ] Burns M. P. et al. Co-localization of cholesterol, apolipoprotein E and fibrillar Aβ in amyloid plaques. Mol. [ncbi.nlm.nih.gov]

Amyloid cutaneous infiltrative lesions like papules, nodules, or plaques with a serous-hemorrhagic aspect were found in the eyelids, neck and retroauricular region, among [ncbi.nlm.nih.gov]

Amyloidosis

Because of this close link, gradual accumulation of A β into amyloid plaques has been reported in brain areas with intense neuronal activity, including cortical regions that [ncbi.nlm.nih.gov]

As a result, further amyloid plaque should not deposit in the organs. [hopkinsmedicine.org]

We present a 71-year-old man that presented to our department because of exuberant purpuric plaques in the anogenital area as the first manifestation of an amyloid light-chain [ncbi.nlm.nih.gov]

Secondary Amyloidosis

Nodules/Plaques of amyloid can be seen in the epi/endocardium Micro: Seen in the coronary vessels or surrounding them. [ilovepathology.com]

Seite 451 - Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked [books.google.de]

In the United Kingdom, a nuclear medicine scan using radiolabeled SAP (serum amyloid P component) has been developed; it is not available elsewhere. [clinicaladvisor.com]

Amyloidosis in Familial Mediterranean Fever

Amyloid — A waxy translucent substance composed mostly of protein, that forms plaques (abnormal deposits) in the brain. [medical-dictionary.thefreedictionary.com]

Amyloidosis — Accumulation of amyloid deposits in various organs and tissues in the body such that normal functioning of an organ is compromised. [medical-dictionary.thefreedictionary.com]

Hepatosplenic Amyloidosis

Amyloid deposits are diffuse and typically involve the posterior wall of the trachea. The lesions are fragile and may bleed after biopsy. [err.ersjournals.com]

Tracheobronchial endoscopy usually shows irregular whitish deposits, most often diffuse, narrowing the airway lumen more or less completely (multifocal submucosal plaques) [err.ersjournals.com]

Early-Onset Alzheimer Disease

It is caused by mutations in the PSEN2 gene which results in the production of a toxic protein (amyloid beta peptide) in the brain which collects into clumps (amyloid plaques [checkorphan.org]

plaque, a substance that builds up in the brain of Alzheimer’s patients years before they start getting sick. [cbsnews.com]

plaques, neurofibrillary tangles, Lewy bodies (seen in Lewy body variant) リンク ICD-11: 8A20 ICD-10: G30 MeSH: D000544 OMIM: 104300 104310 607822 606889 文献 PMID: 19679070 [genome.jp]

Boxer's Dementia

This collective damage is thought to lead to the buildup of amyloid plaque, which causes the symptoms of the disease (though the exact relationship is not yet entirely clear [dementia.org]

This collect damage may lead to the build of amyloid plaque, which causes symptoms of the disease. However, this relationship is not entirely clear. [healthlifemedia.com]

Unlike Alzheimer’s dementia, these tangles typically appear around small blood vessels, and beta-amyloid plaques are only present in certain circumstances. [alz.org]

ABri Amyloidosis

plaques. [en.wikipedia.org]

(A) Illustration of tissues taken from a normal and AD brain, and (B) picture of an actual amyloid plaque as seen under a microscope. [case.edu]

The amyloid plaques are deposits of Aβ peptides organized in 7–10 nm thick fibrils. [nature.com]

ADan Amyloidosis

With these antibodies we were able to identify abundant extracellular amyloid plaques, vascular, and parenchymal deposits in human familial British dementia and FDD brain [discovery.ucl.ac.uk]

The main neuropathological lesions caused by cerebral amyloidosis are cerebral amyloid angiopathy and amyloid plaques. [eprints.ncl.ac.uk]

The amyloid plaques are deposits of Aβ peptides organized in 7–10 nm thick fibrils. [nature.com]

Posterior Cortical Atrophy

Posterior cortical atrophy is a dementia syndrome with symptoms of cortical visual dysfunction, associated with amyloid plaques and neurofibrillary tangles predominantly affecting [ncbi.nlm.nih.gov]

A range of pathogenic mechanisms (e.g., amyloid plaques, Pick bodies, etc) typically underlie corresponding clinical syndromes. [ncbi.nlm.nih.gov]

Determining the relative contribution of amyloid plaques and neurofibrillary tangles to brain dysfunction in Alzheimer disease is critical for therapeutic approaches, but [ncbi.nlm.nih.gov]

Cerebral Cortical Atrophy

plaques that are characteristic of the disease. [massgeneral.org]

In many people with posterior cortical atrophy, the affected part of the brain shows amyloid plaques and neurofibrillary tangles, similar to the changes that occur in Alzheimer [alz.org]

plaques and tau tangles that are directly associated with Alzheimer’s. [massgeneral.org]

Parenchymatous Cortical Cerebellar Degeneration

Diffuse amyloid plaques were specifically noted in the cerebellar molecular layer. [alzforum.org]

Familial cerebral amyloid angiopathy with nonneuritic amyloid plaque formation. Brain. 1990 ; 113 : 721 –47. 27. J. L. Holton, J. Ghiso, T. Lashley, et al. [cambridge.org]

Abundant amyloid plaques were noted throughout the brain, including in all neocortical areas, the hippocampus, basal ganglia, thalamus, and midbrain. [alzforum.org]

Prion Disease

Neuropathological examination during end-stage disease showed the deposition of prion protein in the form of frequent cortical amyloid plaques, cerebral amyloid angiopathy [ncbi.nlm.nih.gov]

Neuropathologically, multiple PrP-positive amyloid plaques and diffuse PrP deposition in the deep cortical layers were found in the cerebral cortex with primarily frontal [ncbi.nlm.nih.gov]

Amyloid plaque formation similar to that found in Alzheimer's disease is conspicuous in many, but not all, of these diseases. [ncbi.nlm.nih.gov]

Dementia

Neuropathological evaluation revealed abundant β-amyloid neuritic and cored plaques, diffuse β-amyloid plaques, and frequent hyperphosphorylated-tau neurofibrillary tangles [ncbi.nlm.nih.gov]

There is a growing body of evidence that both local and systemic inflammation are important in dementia; with cerebral inflammation occurring secondarily to beta-amyloid plaques [ncbi.nlm.nih.gov]

Alzheimer’s disease, by contrast, is characterized by the build-up of amyloid plaques and so-called tau tangles, which are normal proteins run amok. [marketwatch.com]

DDT Exposure

They found that when they exposed the cells to DDE for 48 hours, levels of a protein linked to beta amyloid plaques increased by nearly 50 percent. [webmd.com]

plaques, the brain plaques that are hallmarks of Alzheimer's disease. [livescience.com]

Brain cell studies found that DDT and DDE increased the amount of a protein associated with plaques (called amyloid proteins) believed to be a hallmark of Alzheimer’s disease [nyrnaturalnews.com]

Hereditary Cerebral Amyloid Angiopathy

In Alzheimer ́s disease, misfolded Abeta is deposited mainly in so-called amyloid plaques, whereas in cerebral beta-amyloid angiopathy, the Abeta protein aggregates in the [es.glosbe.com]

[…] vessels in cerebral amyloid angiopathy. [es.glosbe.com]

Similar plaques appear in some variants of Lewy body dementia and in inclusion body myositis (a muscle disease), while Aβ can also form the aggregates that coat cerebral blood [es.glosbe.com]

Spastic Paraplegia with Extrapyramidal Signs

plaques. [link.springer.com]

82–8 CrossRef CAS PubMed Google Scholar Dermaut B, Kumar-Singh S, Engelborghs S, et al. (2004) A novel presenilin 1 mutation associated with Pick’s disease but not beta-amyloid [link.springer.com]

Iatrogenic Jakob-Creutzfeldt Disease

With an analysis of the various forms, of amyloid plaque deposition in the virus-induced spongiform encephalopathies. Brain 1981; 104: 559-88. [ Links ] 65. [scielo.cl]

Gerstmann-Straussler-Scheinker Disease

Gerstmann-Sträussler-Scheinker disease (GSS) Overview Gerstmann-Sträussler-Scheinker disease (GSS) is an extremely rare, neurodegenerative brain disorder caused by prion (proteins) that misfold in the brain, primarily in the cerebellum. Symptoms Typical early symptoms: ataxia (gait changes), balance problems,[…] [cjdfoundation.org]

Creutzfeldt-Jakob Disease Heidenhain Variant

[…] distribution of amyloid plaques (Fig. 2L). [content.iospress.com]

With an analysis of the various forms, of amyloid plaque deposition in the virus-induced spongiform encephalopathies. Brain 1981; 104: 559-88. [ Links ] 65. [scielo.cl]

In the latter, however, PAS positive, unicentric, amyloid plaques were also noticed (Fig. 2I). [content.iospress.com]

Variant Creutzfeldt-Jakob Disease

With an analysis of the various forms, of amyloid plaque deposition in the virus-induced spongiform encephalopathies. Brain 1981; 104: 559-88. [ Links ] 65. [scielo.cl]

Early-Onset Alzheimer Disease Type 3

Amyloid plaques Professor Donna Wilcock describes amyloid plaques as clumps of protein in the brain that are one of the three hallmarks of Alzheimer's disease. [dnalc.cshl.edu]

Several families have had associated spastic paraplegia with "cotton wool" amyloid plaques 7. [centogene.com]

Alzheimer disease (AD) is characterized by adult-onset progressive dementia associated with cerebral cortical atrophy, beta-amyloid plaque formation, and intraneuronal neurofibrillary [ncbi.nlm.nih.gov]

Amyloid Angiopathy

Scattered amyloid diffuse plaques were also seen in the neuropil. [demneuropsy.com.br]

Passive immunotherapy has been proposed as a means of targeting circulating amyloid and plaques for treatment of degenerative diseases associated with brain amyloid deposition [onlinelibrary.wiley.com]

Cerebral amyloid deposition occurs in many forms, including the senile amyloid plaques of Alzheimer disease, parenchymal deposition as in amyloidoma, and deposition in the [ajronline.org]

Alzheimer Disease Type 8

’ and ‘tangles’ are the main reasons that nerve cells are damaged in someone with Alzheimer’s disease.[6] Plaques are a build-up of bits of a protein called beta-amyloid in [ensayosclinicosroche.es]

Most people develop some plaques and tangles as they get older, but people with Alzheimer’s disease tend to develop a lot more than normal, beginning in the areas important [ensayosclinicosroche.es]

[…] brain, which impairs their memory, language and thinking processes, and also affects how they feel and behave.[5] It is thought that two structures in the brain called ‘plaques [ensayosclinicosroche.es]

Tauopathy

PART is almost universally detectable at autopsy among elderly individuals who lack amyloid beta plaques; in advanced old age, approximately 25% of persons lack amyloid beta [medlink.com]

INTRODUCTION: Primary age-related tauopathy (PART) is a neuropathological diagnosis characterized by tau neurofibrillary tangles (NFTs) in the absence of amyloid plaque pathology [ncbi.nlm.nih.gov]

plaques (primary age-related tauopathy [PART] definite) and sparse neuritic plaques (amyloid sparse). [ncbi.nlm.nih.gov]

[…] neuritic plaques with an AD-like biochemical profile, and an unclassifiable 4-repeat tauopathy. [pesquisa.bvs.br]

It is generally regarded as a focal presentation of Alzheimer’s disease (AD) since most patients have amyloid plaques and neurofibrillary tangles, although less commonly Lewy [neurology.org]

There was no amyloid, and there were no neuritic plaques or neurofibrillary tangles, consistent with “not AD” by current criteria ( 14 ). [academic.oup.com]

Cerebral Amyloid Angiopathy

Consequently, amyloid plaques that accumulate in the brain blood vessels are formed. [ivami.com]

These senile plaque and vascular amyloid deposits were specifically stained with an antibody to Abeta. His APOE genotype was epsilon4/epsilon4. [ncbi.nlm.nih.gov]

In addition to the vascular pathology, many diffuse beta-amyloid plaques [Figure 3] d and mature plaques with Congo-red positive dense amyloid cores [Figure 3] c were seen [annalsofian.org]