Amyloid Plaque: Causes & Reasons

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Possible Causes for Amyloid Plaque

Alzheimer Disease

and amyloid load (r=0.091, p=0.016). [ncbi.nlm.nih.gov]

Zinc has actually been shown to reduce the toxic effect of the amyloid plaques by changing the amyloid proteins into a shape that is less harmful to the brain. [alzheimers.org.uk]

Immunisation of patients with Alzheimer's disease with full-length amyloid-beta peptide (Abeta(42)) can clear amyloid plaques from the brain. [ncbi.nlm.nih.gov]

Creutzfeldt Jakob Disease

in addition to disease duration, in generating white matter PrP-amyloid plaques in p-CJDMM1. [ncbi.nlm.nih.gov]

KEYWORDS: Creutzfeldt-Jakob disease; MV2K+C; cerebellum; single unglycosylated band; small amyloid plaques [ncbi.nlm.nih.gov]

Microscopically visible kuru-type amyloid plaques were found in 5% of patients with Creutzfeldt-Jakob disease, 75% of those with kuru, and 100% of those with Gerstmann-Sträussler-Scheinker [ncbi.nlm.nih.gov]

Kuru

These observations strongly suggest that similar glial association with plaque formation may be involved in both kuru and senile plaques, although the amyloid core proteins [ncbi.nlm.nih.gov]

Amyloid plaques, so characteristic of kuru, also did not figure in the similarity, for they had not yet been reported in scrapie. [ncbi.nlm.nih.gov]

Neuropathologically, kuru-affected brains were characterized by widespread degeneration of neurons, astroglial and microglial proliferation, and the presence of amyloid plaques [ncbi.nlm.nih.gov]

Amyloidosis

We present a 71-year-old man that presented to our department because of exuberant purpuric plaques in the anogenital area as the first manifestation of an amyloid light-chain [ncbi.nlm.nih.gov]

Because of this close link, gradual accumulation of A β into amyloid plaques has been reported in brain areas with intense neuronal activity, including cortical regions that [ncbi.nlm.nih.gov]

As a result, further amyloid plaque should not deposit in the organs. [hopkinsmedicine.org]

Systemic Amyloidosis

Amyloid 13, 20–23 (2006). 60. Burns, M. P. et al. Co-localization of cholesterol, apolipoprotein E and fibrillar Aβ in amyloid plaques. Mol. Brain. [doi.org]

Amyloid 13, 20–23 (2006). [ PubMed ] [ Google Scholar ] Burns M. P. et al. Co-localization of cholesterol, apolipoprotein E and fibrillar Aβ in amyloid plaques. Mol. [ncbi.nlm.nih.gov]

Although the causative protein is the main constituent of amyloid plaques, the amyloid proteome is complex and a number of other proteins are frequently co-deposited. [haematologica.org]

Secondary Amyloidosis

Nodules/Plaques of amyloid can be seen in the epi/endocardium Micro: Seen in the coronary vessels or surrounding them. [ilovepathology.com]

Seite 451 - Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked [books.google.de]

In the United Kingdom, a nuclear medicine scan using radiolabeled SAP (serum amyloid P component) has been developed; it is not available elsewhere. [clinicaladvisor.com]

Amyloidosis in Familial Mediterranean Fever

Amyloid — A waxy translucent substance composed mostly of protein, that forms plaques (abnormal deposits) in the brain. [medical-dictionary.thefreedictionary.com]

Amyloidosis — Accumulation of amyloid deposits in various organs and tissues in the body such that normal functioning of an organ is compromised. [medical-dictionary.thefreedictionary.com]

Hepatosplenic Amyloidosis

Amyloid deposits are diffuse and typically involve the posterior wall of the trachea. The lesions are fragile and may bleed after biopsy. [err.ersjournals.com]

Tracheobronchial endoscopy usually shows irregular whitish deposits, most often diffuse, narrowing the airway lumen more or less completely (multifocal submucosal plaques) [err.ersjournals.com]

Gerstmann-Straussler-Scheinker Disease

Boxer's Dementia

This collect damage may lead to the build of amyloid plaque, which causes symptoms of the disease. However, this relationship is not entirely clear. [healthlifemedia.com]

This collective damage is thought to lead to the buildup of amyloid plaque, which causes the symptoms of the disease (though the exact relationship is not yet entirely clear [dementia.org]

Unlike Alzheimer’s dementia, these tangles typically appear around small blood vessels, and beta-amyloid plaques are only present in certain circumstances. [alz.org]

Early-Onset Alzheimer Disease

It is caused by mutations in the PSEN2 gene which results in the production of a toxic protein (amyloid beta peptide) in the brain which collects into clumps (amyloid plaques [checkorphan.org]

plaque, a substance that builds up in the brain of Alzheimer’s patients years before they start getting sick. [cbsnews.com]

plaques, neurofibrillary tangles, Lewy bodies (seen in Lewy body variant) リンク ICD-11: 8A20 ICD-10: G30 MeSH: D000544 OMIM: 104300 104310 607822 606889 文献 PMID: 19679070 [genome.jp]

ABri Amyloidosis

plaques. [en.wikipedia.org]

(A) Illustration of tissues taken from a normal and AD brain, and (B) picture of an actual amyloid plaque as seen under a microscope. [case.edu]

The amyloid plaques are deposits of Aβ peptides organized in 7–10 nm thick fibrils. [nature.com]

ADan Amyloidosis

With these antibodies we were able to identify abundant extracellular amyloid plaques, vascular, and parenchymal deposits in human familial British dementia and FDD brain [discovery.ucl.ac.uk]

The amyloid plaques are deposits of Aβ peptides organized in 7–10 nm thick fibrils. [nature.com]

Cerebral amyloid and preamyloid deposits of two unrelated molecules (Danish amyloid (ADan) and beta-amyloid (Abeta)), the absence of compact plaques, and neurofibrillary degeneration [uniprot.org]

Cerebral Cortical Atrophy

plaques that are characteristic of the disease. [massgeneral.org]

In many people with posterior cortical atrophy, the affected part of the brain shows amyloid plaques and neurofibrillary tangles, similar to the changes that occur in Alzheimer [alz.org]

plaques and tau tangles that are directly associated with Alzheimer’s. [massgeneral.org]

Posterior Cortical Atrophy

Posterior cortical atrophy is a dementia syndrome with symptoms of cortical visual dysfunction, associated with amyloid plaques and neurofibrillary tangles predominantly affecting [ncbi.nlm.nih.gov]

A range of pathogenic mechanisms (e.g., amyloid plaques, Pick bodies, etc) typically underlie corresponding clinical syndromes. [ncbi.nlm.nih.gov]

Determining the relative contribution of amyloid plaques and neurofibrillary tangles to brain dysfunction in Alzheimer disease is critical for therapeutic approaches, but [ncbi.nlm.nih.gov]

Parenchymatous Cortical Cerebellar Degeneration

Diffuse amyloid plaques were specifically noted in the cerebellar molecular layer. [alzforum.org]

Familial cerebral amyloid angiopathy with nonneuritic amyloid plaque formation. Brain. 1990 ; 113 : 721 –47. 27. J. L. Holton, J. Ghiso, T. Lashley, et al. [cambridge.org]

Abundant amyloid plaques were noted throughout the brain, including in all neocortical areas, the hippocampus, basal ganglia, thalamus, and midbrain. [alzforum.org]

Prion Disease

Neuropathological examination during end-stage disease showed the deposition of prion protein in the form of frequent cortical amyloid plaques, cerebral amyloid angiopathy [ncbi.nlm.nih.gov]

Neuropathologically, multiple PrP-positive amyloid plaques and diffuse PrP deposition in the deep cortical layers were found in the cerebral cortex with primarily frontal [ncbi.nlm.nih.gov]

Amyloid plaque formation similar to that found in Alzheimer's disease is conspicuous in many, but not all, of these diseases. [ncbi.nlm.nih.gov]

Van Buchem Disease

plaques in transgenic mouse models of Alzheimer's disease. [onlinelibrary.wiley.com]

Although the pathophysiological consequences of accumulation of β-amyloid in the brain are uncertain, neuropathological identification of amyloid plaques, typically at autopsy [nejm.org]

Four novel ligands showing preferential labeling of amyloid aggregates of Aβ(1−40) and Aβ(1−42) peptides, commonly associated with plaques in the brain of people with Alzheimer's [pubs.acs.org]

DDT Exposure

They found that when they exposed the cells to DDE for 48 hours, levels of a protein linked to beta amyloid plaques increased by nearly 50 percent. [webmd.com]

plaques, the brain plaques that are hallmarks of Alzheimer's disease. [livescience.com]

Brain cell studies found that DDT and DDE increased the amount of a protein associated with plaques (called amyloid proteins) believed to be a hallmark of Alzheimer’s disease [nyrnaturalnews.com]

Binswanger Disease

Cerebral vascular amyloid deposits, senile plaques and neurofibrillary tangles have been found in subcortical arteriosclerotic encephalopathy (Binswanger disease). [ncbi.nlm.nih.gov]

Unlike AD, FTD usually does not include formation of amyloid plaques. [alzheimersweekly.com]

CONCLUSION The diagnosis of AD is made radiologically by observing changes in the hippocampus and deposition of amyloid plaque. [surgicalneurologyint.com]

Pineal Gland Dysfunction

(Aβ), known as amyloid plaques – and sleep reduces Aβ. [infowars.com]

It also failed at removing amyloid plaques from the brain. [infowars.com]

So while pharmaceutical companies spend billions on ways to stop amyloid plaque buildup, they aren’t looking at the root cause of the calcification of the pineal gland which [infowars.com]

Drug-Induced Dementia

The guide states that “Alzheimer’s is distinguished from other dementias at autopsy by the presence of sticky beta-amyloid plaques outside brain cells (neurons) and fibrillary [thepeoplesvoice.org]

The guide states that: “Alzheimer’s is distinguished from other dementias at autopsy by the presence of sticky beta-amyloid plaques outside brain cells (neurons) and fibrillary [ppjg.me]

Gram Negative Bacterial Infection

Also LPS co-localized with amyloid β in amyloid plaques and in blood vessels of Alzheimer's brains." [sciencedaily.com]

It's noteworthy that LPS co-localized with the neurotoxic peptide amyloid β in amyloid plaques and in the blood vessels of Alzheimer's brains. [holisticprimarycare.net]

This research follows previous animal studies in the Sharp lab that showed bacterial LPS plus ischemia/hypoxia can increase amyloid β and produce amyloid plaque-like aggregates [sciencedaily.com]

Anosognosia

Right prosubiculum amyloid plaque density correlates with anosognosia in Alzheimer's disease. [thieme-connect.com]

Early-Onset Alzheimer Disease Type 3

Amyloid plaques Professor Donna Wilcock describes amyloid plaques as clumps of protein in the brain that are one of the three hallmarks of Alzheimer's disease. [dnalc.cshl.edu]

Several families have had associated spastic paraplegia with "cotton wool" amyloid plaques 7. [centogene.com]

Alzheimer disease (AD) is characterized by adult-onset progressive dementia associated with cerebral cortical atrophy, beta-amyloid plaque formation, and intraneuronal neurofibrillary [ncbi.nlm.nih.gov]

Amyloid Angiopathy

Scattered amyloid diffuse plaques were also seen in the neuropil. [demneuropsy.com.br]

Passive immunotherapy has been proposed as a means of targeting circulating amyloid and plaques for treatment of degenerative diseases associated with brain amyloid deposition [onlinelibrary.wiley.com]

Cerebral amyloid deposition occurs in many forms, including the senile amyloid plaques of Alzheimer disease, parenchymal deposition as in amyloidoma, and deposition in the [ajronline.org]

[…] neuritic plaques with an AD-like biochemical profile, and an unclassifiable 4-repeat tauopathy. [pesquisa.bvs.br]

It is generally regarded as a focal presentation of Alzheimer’s disease (AD) since most patients have amyloid plaques and neurofibrillary tangles, although less commonly Lewy [neurology.org]

Neurology 71, 1191 - 1197 70 Dermaut, B. et al. ( 2004 ) A novel presenilin 1 mutation associated with Pick's disease but not beta-amyloid plaques. [cambridge.org]

Primary Lateral Sclerosis

Numerous beta/A4 amyloid positive diffuse plaques (10-15/200x field) were apparent in neocortex, and neurofibrillary tangles immunopositive for paired helical filament were [ncbi.nlm.nih.gov]

Atypical dementia and spastic paraplegia in a patient with primary lateral sclerosis and numerous neocortical beta amyloid plaques: New disorder or Alzheimer's disease variant [malattierare.regione.veneto.it]

Atypical dementia and spastic paraplegia in a patient with primary lateral sclerosis and numerous neocortical beta amyloid plaques: new disorder of Alzheimer's disease variant [doi.org]

Tauopathy

PART is almost universally detectable at autopsy among elderly individuals who lack amyloid beta plaques; in advanced old age, approximately 25% of persons lack amyloid beta [medlink.com]

INTRODUCTION: Primary age-related tauopathy (PART) is a neuropathological diagnosis characterized by tau neurofibrillary tangles (NFTs) in the absence of amyloid plaque pathology [ncbi.nlm.nih.gov]

plaques (primary age-related tauopathy [PART] definite) and sparse neuritic plaques (amyloid sparse). [ncbi.nlm.nih.gov]

Cerebral Amyloid Angiopathy

Consequently, amyloid plaques that accumulate in the brain blood vessels are formed. [ivami.com]

In addition to the vascular pathology, many diffuse beta-amyloid plaques [Figure 3] d and mature plaques with Congo-red positive dense amyloid cores [Figure 3] c were seen [annalsofian.org]

Aβ is the component of amyloid plaques. [wikivisually.com]