Amyloidosis: Causes & Reasons

Possible Causes for Amyloidosis

We herein report this first case of amyloid polyneuropathy and myocardial amyloidosis after DLT from hereditary ATTR amyloidosis with a transthyretin Ser50Arg mutation and [ncbi.nlm.nih.gov]

[…] polyneuropathy [ pol″e-noo͡-rop´ah-the ] a disease involving several nerves. amyloid polyneuropathy polyneuropathy caused by amyloidosis ; symptoms may include dysfunction [medical-dictionary.thefreedictionary.com]

This case indicates that several biopsy sites other than nerves may be helpful and necessary for the diagnosis of TTR amyloidosis in mild or late-onset FAP. [ncbi.nlm.nih.gov]

Glomerulonephritis

IgA or IgM) restriction (AH amyloidosis) on immunofluorescence, negative DNAJB9 immunohistochemistry, positive Amyloid A protein on immunohistochemistry (AA amyloidosis) [pathologyoutlines.com]

The most common cause of kidney involvement is AA type amyloidosis. Effective ad common use of colchicine decreased amyloidosis frequency when compared to before. [adudspace.adu.edu.tr]

[…] relies on renal biopsy findings of haphazardly arranged fibrils in all glomerular compartments and distinction from other forms of fibrillary glomerulopathies such as renal amyloidosis [ncbi.nlm.nih.gov]

Multiple Myeloma

In general, the presentation of hepatic amyloidosis varies with minimal or no symptoms commonly seen. Hepatic amyloidosis is rarely associated with multiple myeloma. [ncbi.nlm.nih.gov]

amyloidosis. [hematologyandoncology.net]

Systemic amyloidosis may be primary or in association with multiple myeloma and typically affecting elder adults. [ncbi.nlm.nih.gov]

Cryopyrin-Associated Periodic Syndrome

AA amyloidosis is a complication of this syndrome. A 53-year-old man was referred to us because of lower limb edema. [ncbi.nlm.nih.gov]

She was diagnosed with renal amyloidosis at 32 years of age. [ncbi.nlm.nih.gov]

Response (Luis Bolaños): AA amyloid material is the precursor protein to secondary or reactive amyloidosis. [revistanefrologia.com]

Nephrotic Syndrome

Amyloidosis represents a rare group of diseases in which abnormal protein, namely amyloid fibrils, build up in various organs. [ncbi.nlm.nih.gov]

One frequent form of renal involvement is amyloidosis, especially in patients with lepromatous leprosy. [ncbi.nlm.nih.gov]

The most common presentation of hepatic amyloidosis is hepatomegaly with elevated alkaline phosphatase. [ncbi.nlm.nih.gov]

Amyloidosis

Thus, it is termed AA amyloidosis. AA amyloidosis usually begins as disease in the kidneys, but other organs can be affected. [bu.edu]

What Is Amyloidosis? Amyloidosis occurs when proteins accumulate abnormally in various body organs. The proteins, called amyloid fibrils, can accumulate in many organs. [stanfordhealthcare.org]

[…] are supported by organizations, including the Amyloidosis Research Consortium, Amyloidosis Foundation, Amyloidosis Support Groups, and Amyloidosis Australia.[22][23] Prognosis [en.wikipedia.org]

Muckle-Wells Syndrome

We describe a family with nephropathy and several symptoms of MWS, but no evidence of deafness or amyloidosis. [ncbi.nlm.nih.gov]

A case of hereditary AA amyloidosis with Muckle-Wells syndrome is described. [ncbi.nlm.nih.gov]

Response (Luis Bolaños): AA amyloid material is the precursor protein to secondary or reactive amyloidosis. [revistanefrologia.com]

Familial Mediterranean Fever

Amyloidosis cutis dyschromica is a rare type of primary cutaneous amyloidosis characterized by reticulate hyper-pigmentation with discrete hypopigmented macules. [ncbi.nlm.nih.gov]

However, homozygosis for SAA1 α/α polymorphism was associated with proteinuria and amyloidosis whereas carrying the β/β polymorphism was found to be protective for amyloidosis [ncbi.nlm.nih.gov]

MATERIALS AND METHODS: A total of 240 individuals consisting of 40 patients with FMF-related amyloidosis, 100 FMF patients without amyloidosis, and 100 healthy controls were [ncbi.nlm.nih.gov]

Multiple Endocrine Neoplasia

Cutaneous manifestations of MEN 2A syndrome include macular amyloidosis, whereas MEN 2B syndrome is traditionally linked to multiple mucosal neuromas. [ncbi.nlm.nih.gov]

MEN2a mainly focuses on medullary thyroid carcinoma, pheochromocytoma, parathyroid hyperplasia or adenomas (causing hyperparathyroidism), and occasionally cutaneous lichen amyloidosis [ronnyallan.net]

[…] thyroid carcinoma, pheochromocytoma, hyperplasia or sometimes adenomas of the parathyroid glands (with resultant hyperparathyroidism), and occasionally cutaneous lichen amyloidosis [msdmanuals.com]

Castleman Disease

The treatment of amyloidosis secondary to CD remains to be uncertain. [ncbi.nlm.nih.gov]

Castleman disease treatment improves amyloidosis manifestations, as well. [symptoma.com]

Relapses are rare. • Some patients with localized CD develop secondary amyloidosis, This protein build-up stops once the lymph node affected by CD is removed. 15. [slideshare.net]

Paraneoplastic Syndrome

Renal syndromes Secondary kidney amyloidosis and sedimentation of immunocomplexes in nephrons (and subsequent membranoproliferative glomerulonephritis) is thought to be the [emedicine.com]

Renal Osteodystrophy

[…] severity of secondary hyperparathyroidism Bowing of long bones Rugger Jersey spine - Osteosclerosis of the end plates of the vertebral bodies Brown Tumor (rare) - Rib or jaw Amyloidosis [gait.aidi.udel.edu]

Amyloidosis may cause erosion in and around a joint, resulting in subtle radiographic signs that are more clearly delineated with cross-sectional imaging techniques such as [emedicine.com]

Amyloidosis may cause erosion in and around a joint, resulting in subtle radiographic signs, while amyloid deposits can be visualized directly on MRI. [13] Radiographic usefulness [emedicine.com]

Diabetic Nephropathy

In such cases, the differential diagnosis includes membranoproliferative glomerulonephritis, light or heavy chain deposition disease, amyloidosis, fibrillary and immunotactoid [ncbi.nlm.nih.gov]

[…] masses in peripheral of glomerulus, PAS+, eventually obliterates glomerular tuft; specific for diabetes and membranoproliferative glomerulonephritis, light chain disease and amyloidosis [pathologyoutlines.com]

Chronic infection, systemic amyloidosis, lymphoproliferative disease, long-term dialysis, family inheritance Mesangial nodular sclerosis; Congo red (+) Light chain (+) in [hindawi.com]

Small Intestinal Bacterial Overgrowth

Have adhesions (scar tissue) that developed after radiation therapy or after multiple abdominal surgeries Have amyloidosis (a buildup of amyloid protein deposits) — deposits [hopkinsmedicine.org]

Intestinal motility disorders associated with diabetic neuropathy, systemic sclerosis, amyloidosis, hypothyroidism, and idiopathic intestinal pseudo-obstruction can also impair [merckmanuals.com]

Disorders such as diabetes, systemic sclerosis, and amyloidosis also can slow peristalsis, causing bacterial overgrowth. [msdmanuals.com]

Common Variable Immunodeficiency

Secondary amyloidosis develops from chronic inflammatory conditions. [ncbi.nlm.nih.gov]

Secondary, inflammatory (AA type) amyloidosis has infrequently been observed in CVID patients. [ncbi.nlm.nih.gov]

[…] transient hypogammalglobulinaemia in infancy Acquired multiple myeloma chronic lymphocytic leukemia (CLL) - hypogammaglobulinemia is present in up to 85% of CLL patients primary amyloidosis [radiopaedia.org]

Behçet Disease

Complication of amyloidosis in patients with BD is rare. Here, we report a case of BD with immunoglobulin light chain (AL)-amyloidosis manifested as hematochezia. [ncbi.nlm.nih.gov]

Pulmonary Involvement In Hereditary Lysozyme Amyloidosis With Associated Pulmonary Sarcoidosis Alexander P. Deegan, John F. Garvey, and Timothy J. [atsjournals.org]

Hamza M, Wechsler B, Godeau P, Hamza H, Ayed K (1988) Intestinal amyloidosis: an unusual complication of Behcet’s disease. [dx.doi.org]

Primary Myelofibrosis

Other causes include small cell tumors of childhood, Mast cell disease, Disseminated granulomatous disease, Primary amyloidosis, Metabolic bone disease etc. [news-medical.net]

Abnormalities of humoral immunity: variety of autoantibodies and circulating immune complexes may be detected and amyloidosis may develop. [patient.info]

A variety of autoantibodies and circulating immune complexes may be detected, and amyloidosis may develop. [emedicine.medscape.com]

Trigeminal Neuropathy

There was no evidence of systemic amyloidosis or underlying inflammatory or neoplastic disorders. [ncbi.nlm.nih.gov]

Leprosy

One frequent form of renal involvement is amyloidosis, especially in patients with lepromatous leprosy. [ncbi.nlm.nih.gov]

Leprosy was not suspected before skin biopsy in three cases, while noninfectious diagnoses were considered, including mycosis fungoides, erythema multiforme, vasculitis, and amyloidosis [ncbi.nlm.nih.gov]

Renal damage may occur due to type 2 reactions or by secondary amyloidosis affecting many organs. [news-medical.net]

Kidney Failure

One type of kidney problem found in people with longstanding RA is amyloidosis. [arthritis.org]

"Amyloidosis and Kidney Disease." Updated: Sep 2014. [rxlist.com]

"Amyloidosis and Kidney Disease." Updated: Sep 2014. CONTINUE SCROLLING FOR RELATED SLIDESHOW [medicinenet.com]

Ulcerative Colitis

Group C, found in a small percentage of patients, consists of nonspecific complications, including osteoporosis (3%), liver disease (5%), peptic ulcer (10%), and amyloidosis [ncbi.nlm.nih.gov]

Early diagnosis autoinflammatory disease may prevent complications related to unnecessary immunosuppressive drug usage and the risk of development of amyloidosis associated [ncbi.nlm.nih.gov]

Gaucher Disease

Primary amyloidosis, a well-recognized consequence of hypergammaglobulinemia, has also been reported in Gaucher disease [64–66]. [hindawi.com]

If any of these conditions is present or a deterioration of the disease occurs, investigations for amyloidosis, as a secondary complication of Gaucher disease, must be made [haematologica.org]

This is also the case for other malignancies as Non-Hodgkin lymphomas and primary amyloidosis. [oatext.com]

Whipple Disease

Diagnosis Code M14.8 Arthropathies in other specified diseases classified elsewhere 2016 2017 2018 2019 Non-Billable/Non-Specific Code Code First underlying disease, such as: amyloidosis [icd10data.com]

Diverticulosis and Diverticulitis Hirschsprung Disease Small Bowel Diverticulosis Severe Idiopathic Constipation Solitary Rectal Ulcer Syndrome/Mucosal Prolapse Gastrointestinal Amyloidosis [euro-libris.ro]

Gaucher Disease Type 1

1 不要有 HPS2018 HPS2019 HPS2020 HPS2021 HPS2022 HPS2023 Systemic amyloidosis, AL amyloidosis 全身性アミロイドーシス免疫性 1 不要有 HPS2024 HPS2025 HPS2026 HPS2027 HPS2028 HPS2029 171. [cell.brc.riken.jp]

See AL amyloidosis Primary systemic amyloidosis - See AL amyloidosis Primary T-Cell Immunodeficiency Disorders - See T cell immunodeficiency primary Primary thrombocythemia [rarediseases.info.nih.gov]

Diagnosis Necrobiotic xanthogranuloma Orbital lipogranulomas Juvenile xanthogranulomata Erdheim-Chester disease Wegener granulomatosis Lipoid proteinosis Primary systemic amyloidosis [statpearls.com]

Cystitis

This is an inflammation caused most frequently, by bacterial infection of the bladder. Occasionally, viruses and fungi can be the cause of acute cystitis. A.Vogel Urinary Tract experts look at cystitis causes, symptoms and recommends solutions to help you. There's also a Q&A service where you can get answers to all[…] [avogel.ca]

Crohn Disease

These complications include Deposits of the protein amyloid in several organs (amyloidosis) When Crohn disease causes a flare-up of gastrointestinal symptoms, the person may [msdmanuals.com]

Cardiomyopathy

Tafamidis meglumine, a transthyretin (TTR) stabilizer, is effective in delaying the progression of neuropathy in TTR amyloidosis with Val30Met mutations. [ncbi.nlm.nih.gov]

Cardiac amyloidosis can resemble HCM; symmetric LV thickening is typical of amyloidosis but also occurs in HCM, and restrictive physiology and poor compliance may be present [emedicine.com]

Causes include: amyloidosis, endomyocardial fibrosis, and idiopathic. [patient.info]

Orthostatic Syncope

serum and urine protein electrophoresis for primary amyloidosis — Diabetic autonomic neuropathy Neuropathic changes associated with poor glycemic control Associated with [aafp.org]

It may result from a primary disturbance of autonomic regulation or more commonly as a secondary effect of another systemic disorder (eg, diabetes, amyloidosis). [emedicine.medscape.com]

Some nervous system disorders, such as Parkinson's disease, multiple system atrophy, Lewy body dementia, pure autonomic failure and amyloidosis, can disrupt your body's normal [mayoclinic.org]

IgE Myeloma

Cardiac amyloidosis was found in 45% vs 56% of patients with IgD vs non-IgD amyloidosis (P = .047), and renal amyloidosis was noted in 36% vs 58% of these two groups of patients [cancernetwork.com]

[…] other isotypic forms of myeloma and associated amyloidosis.[10] While it is commonly accepted that IgD amyloidosis is a distinct entity,[10] recent studies have identified [cancernetwork.com]

As noted, Blad et al[6] found amyloidosis in 19% of patients. [cancernetwork.com]

Autonomic Neuropathy

Nine of the patients had AL amyloidosis, two had familial amyloidosis associated with a transthyretin abnormality, and one was untyped. [ncbi.nlm.nih.gov]

Vitreous amyloidosis should be considered a differential diagnosis of uveitis, in particular transthyretin amyloidosis. [ncbi.nlm.nih.gov]

Causes include diabetes, amyloidosis, autoimmune disorders, cancer, excessive alcohol consumption, and certain drugs. [merckmanuals.com]