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513 Possible Causes for Amyloidosis, Decreased Platelet Count

  • Primary Myelofibrosis

    Abnormalities of humoral immunity: variety of autoantibodies and circulating immune complexes may be detected and amyloidosis may develop.[patient.info] Decreasing platelet counts in ET to below 600 x 10 9 /L can decrease thrombotic complications. 46 High platelet counts ( 1,000 x 10 9 /L) are associated with acquired von[clevelandclinicmeded.com] A variety of autoantibodies and circulating immune complexes may be detected, and amyloidosis may develop.[emedicine.medscape.com]

  • Castleman Disease

    The treatment of amyloidosis secondary to CD remains to be uncertain.[ncbi.nlm.nih.gov] The observed side effects were low platelet counts and low fibrin levels, with no macrophage activation syndrome ( Fig. 1 ) and an episode of herpes zoster.[mct.aacrjournals.org] count (thrombocytopenia) Elevated lymphocytes and plasma cells (polyclonal lymphocytosis and plasmacytosis) Elevated BUN and creatinine (decreased kidney function) Proteinuria[cdcn.org]

  • Multiple Myeloma

    In general, the presentation of hepatic amyloidosis varies with minimal or no symptoms commonly seen. Hepatic amyloidosis is rarely associated with multiple myeloma.[ncbi.nlm.nih.gov] Decreases in blood cell counts. DARZALEX can decrease white blood cell counts which help fight infections and blood cells called platelets which help to clot blood.[darzalex.com] […] absolute neutrophil count, decreased phosphorus, anemia, neutropenia, decreased total white blood cell count, decreased platelets, diarrhea, fatigue, thrombocytopenia, pyrexia[investors.amgen.com]

  • Waldenstrom Macroglobulinemia

    Localized amyloidosis of the tonsil is rare and its management depends on the etiology.[ncbi.nlm.nih.gov] Decreased blood counts (white blood cells, platelets, and red blood cells) are common with IMBRUVICA , but can also be severe.[imbruvica.com] Complete blood counts may show a decrease in the numbers of normal healthy blood cells, such as red blood cells, platelets, and white blood cells.[verywell.com]

  • Vitamin B12 Deficiency

    Intestinal malabsorption: chronic pancreatitis (exocrine insufficiency), Crohn's disease, Whipple's disease, celiac disease, amyloidosis, scleroderma, intestinal lymphomas[doi.org] Other laboratory findings associated with megaloblastic anemia include decreased white blood cell (WBC) count and platelet count.[labtestsonline.org]

  • Heavy Chain Disease

    As in AL-amyloidosis, treatment should be aimed at reducing Ig production.[cjasn.asnjournals.org] Immunoglobulin heavy-chain-associated amyloidosis. Proc Natl Acad Sci U S A 1990 ;87: 6542 - 6546 5.[nejm.org] Diagnosis and typing of systemic amyloidosis: The role of abdominal fat pad fine needle aspiration biopsy. Cytojournal. 2010 Jan 15;6:24.[surgpathcriteria.stanford.edu]

  • Thrombocytopenia

    Herein we describe four cases of immune thrombocytopenia (ITP) occurred during Lenalidomide (LEN) therapy in 3 patients affected by MM and 1 with light‐chain amyloidosis.[bloodjournal.org] PGRN deficiency further decreased platelet count in a passive-transfer ITP murine model.[ncbi.nlm.nih.gov] Her platelet count decreased to 41   10/L, but was stable at 30   10/L for 3 months with platelet transfusion independency for 12 months.[ncbi.nlm.nih.gov]

  • Chronic Kidney Insufficiency

    Other causes of chronic kidney disease include HIV infection, sickle cell disease, heroin abuse, amyloidosis, kidney stones, chronic kidney infections, and certain cancers[emedicinehealth.com] Congenital obstructive urinary flow disorders, chronic-recurrent nephrolithiasis or amyloidosis can permanently damage the kidneys and lead to chronic renal failure.[lecturio.com] Another form of bone disease is dialysis-related amyloidosis, which is now uncommon in the era of improved dialysis membranes.[emedicine.medscape.com]

  • Coagulation Abnormalities

    Abstract Haemorrhage is a frequent manifestation of amyloidosis.[ncbi.nlm.nih.gov] Approximately 37% CLD cases had decreased platelet count and 15% cases had decreased serum fibrinogen level.[ncbi.nlm.nih.gov] The highest levels were observed in patients with systemic amyloidosis. RESULTS: We observed several coagulation abnormalities in patients with different PCDs.[ncbi.nlm.nih.gov]

  • Chronic Congestive Splenomegaly

    […] lymphomas–Hodgkin's disease, NHL • Nonmalignant Hemolytic anemia, histiocytosis, ITP Storage diseases Gaucher's disease, mucopolysaccharidosis, Niemann-Pick disease Etc Amyloidosis[medical-dictionary.thefreedictionary.com] […] and thus the amount of hemoglobin), leukopenia (low white blood cell count) and thrombocytopenia (low platelet count).[bendomd.com] […] spleen A cyst, a noncancerous fluid-filled sac A large abscess, a pus-filled cavity usually caused by a bacterial infection Infiltrative diseases such as Gaucher disease, amyloidosis[webmd.com]

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